Acupuncture for the Treatment of Insomnia - A Pilot Study

针灸治疗失眠——一项初步研究

• 批准号: 7776946
• 负责人: Ronald M. Glick
• 金额: $ 18.75万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7776946
• 关键词: Acupuncture procedure; Adult; Agonist; Anxiety; Behavioral; Benzodiazepine Receptor; Blinded; Chinese Traditional Medicine; Clinical Trials; Cognitive Therapy; Comorbidity; Complementary and alternative medicine; Consultations; Equipment and supply inventories; Fatigue; Future; Individual; Intervention; Literature; Measures; Medical; Mental Depression; Modality; Moods; Needles; Patient Self-Report; Physiology; Pilot Projects; Placebos; Polysomnography; Preparation; Protocols documentation; Randomized; Randomized Controlled Trials; Reporting; Research Design; Research Support; Sample Size; Severities; Sleep; Sleep Fragmentations; Sleeplessness; Symptoms; Testing; Traditional Medicine; Treatment Protocols; base; common treatment; cost; depressive symptoms; indexing; premature; public health relevance; success; trait

DESCRIPTION (provided by applicant): Insomnia is a common problem that is disabling and that frequently persists despite available medical and behavioral approaches. It is associated significant psychiatric and medical comorbidities and high medical and societal costs. Benzodiazepine receptor agonists (BzRA's) and cognitive behavioral therapies are common treatments, but despite these, insomnia remains a pervasive problem. Complementary and alternative medicine (CAM) treatments are being used widely for the treatment of insomnia, but many of these modalities have sparse research support. There are numerous reports in the Traditional Chinese Medicine (TCM) literature of dramatic benefits of acupuncture for the treatment of insomnia, but carefully designed studies are limited. Insomnia has been associated with hyperarousal and acupuncture has documented effects on autonomics with a shift towards parasympathetic predominance. In consultation with experts in acupuncture and TCM, we developed a protocol for the treatment of insomnia and have used it clinically with good success. We will be conducting a 3-year exploratory pilot randomized-controlled blinded trial (RCT) of this protocol on 56 adults with insomnia disorder, utilizing a control condition involving placement of placebo needles. We seek to determine the effect size of this acupuncture intervention in comparison to the control condition in preparation for a more definitive study, with the future primary aim to determine if acupuncture is effective and well- tolerated in the treatment of insomnia. Measures will include self-report and objective measures of sleep quality and duration including polysomnography (PSG). Secondary-exploratory aims will be to determine the impact of this acupuncture protocol on daytime symptoms of insomnia such as fatigue, anxiety, and depression as well as to explore the impact of acupuncture on self-report and objective measures of hyperarousal. PUBLIC HEALTH RELEVANCE: Insomnia is a common and disabling condition associated with psychiatric and medical comorbidities and often persists despite currently available treatments. Acupuncture has been reported to benefit individuals with insomnia and can decrease hyperarousal. This blinded RCT will investigate the impact of a standardized acupuncture protocol on insomnia, daytime symptoms, and hyperarousal.

描述（由申请人提供）：失眠是一个常见的问题，尽管有医疗和行为方法，但经常持续存在。它与大量的精神病和医学合并症以及高医疗和社会成本相关联。苯二氮卓受体激动剂（BZRA）和认知行为疗法是常见的治疗方法，但是尽管如此，失眠仍然是一个普遍的问题。互补和替代医学（CAM）治疗已被广泛用于治疗失眠症，但其中许多方法具有稀疏的研究支持。传统中药（TCM）文献中有许多报道，指针对治疗失眠的巨大益处，但精心设计的研究受到限制。失眠与高阳极和针灸有关，已经证明了对自治的影响，并转向副交感神经优势。在与针灸和TCM专家协商时，我们开发了一种治疗失眠症的方案，并在临床上使用它并取得了良好的成功。我们将利用涉及安慰剂针的控制条件进行对56名失眠症的56名成年人的探索性试验随机控制的盲试试验（RCT）。与对照条件相比，我们试图确定这种针灸干预的效果大小，以准备进行更确定的研究，未来的主要目的是确定针灸在失眠症治疗中是否有效且易于耐受性。措施将包括自我报告和睡眠质量和持续时间的客观措施，包括多个术语（PSG）。次要探索目的将是确定该针灸方案对疲劳，焦虑和抑郁等失眠症症状的影响，以及探索针灸对自我报告和客观过度促进的影响。 公共卫生相关性：失眠是与精神病和医学合并症有关的常见且残疾的疾病，尽管目前可用的治疗方法经常持续存在。据报道，针灸可以使失眠的个体受益，并可以减少高音。该盲人RCT将研究标准化针灸方案对失眠，白天症状和高音的影响。