Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular Risk

青少年肥胖/心血管风险的生物心理社会决定因素

• 批准号: 7911434
• 负责人: SHEILA GAHAGAN
• 金额: $ 12.56万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7911434
• 关键词: 10 year old; Address; Adolescence; Adolescent; Adolescent Development; Age; Area; Back; Behavioral; Biological; Birth; Body Composition; Body mass index; Breast Feeding; Budgets; Cardiovascular Diseases; Caregivers; Child; Childhood; Chile; Circadian Rhythms; Collection; Communities; Confidentiality; Data; Data Collection; Development; Eating; Eating Behavior; Environment; Epidemiology; Evaluation; Family; Feeding Patterns; Food; Grant; Growth; Health; Hispanics; Human Subject Research; Individual; Infant; International Aspects; Iron deficiency anemia; Latin America; Lead; Life Cycle Stages; Link; Living Wills; Longitudinal Studies; Low income; Mails; Measurement; Mentored Patient-Oriented Research Career Development Award; Metabolic syndrome; Methodology; Methods; Modeling; Monitor; Nature; Neighborhoods; Non-Insulin-Dependent Diabetes Mellitus; Nutritional; Obesity; Occupations; Pathway interactions; Pattern; Performance; Physical activity; Population; Prevalence; Principal Investigator; Procedures; Protocols documentation; Qualifying; Research; Research Design; Research Personnel; Research Project Grants; Rest; Rewards; Risk; Role; Safety; Schools; Sleep; Social Conditions; Staging; Suggestion; Time; Visit; Work; Writing; Youth; biopsychosocial; cardiovascular risk factor; clinically relevant; cohort; environmental change; experience; family influence; feeding; health disparity; infancy; innovation; longitudinal analysis; multilevel analysis; neurodevelopment; novel; obesity in children; obesity risk; peer; prevent; psychosocial; social; socioeconomics; standard measure

DESCRIPTION (provided by applicant): The prevalence of adolescent obesity is high in the U.S., and in Latin America. While dramatic environmental changes in the food and physical environment are associated with increased risk, there continues to be inadequate understanding of the individual, family and community level factors that protect against the development of obesity. Further research is needed to understand the mechanisms leading to disparate risk for obesity in low-income and Hispanic/Latino youth. The proposed 5-year project aims to elucidate interconnected biological and social pathways associated with adolescent obesity and risk for later development of type 2 diabetes and cardiovascular disease. This application involves approximately 620 Chilean adolescents, assessed in infancy, 3 to 5 years and 10 years as part of a NIH-supported cohort study of the behavioral and developmental effects of preventing iron deficiency anemia in infancy (n = 1645). As such, detailed longitudinal data related to growth, health and development have been collected. At 16 to 17 years, the youth will participate in study of activity, sleep and eating patterns using actigraphic recording and laboratory assessment of eating behavior. In addition, we will measure anthropometry, fat and muscle mass (DXA), fasting glucose, insulin (HOMA IR), lipids, leptin, ghrelin, adiponectin, orexin, CRP, and TNF alpha. Detailed information about family history, smoking, health, and psychosocial functioning will also be collected. Neighborhood level factors such as crime, walk ability and resources for physical activity and healthful food attributes will be assessed. Furthermore, a sizeable subset (n = 237) with sleep neurophysiology and actigraphic recordings at multiple time points will participate in 2-night polysmnographic sleep study at 16 years. Guided by a life-course approach, we propose to investigate three Specific Aims: Specific Aim 1 - To evaluate biological and psychosocial determinants of obesity and related metabolic disturbance in a cohort of adolescents followed since early infancy. Specific Aim 2 - To assess associations between obesity/adiposity and biomarkers of adiposity-related metabolic disturbance in this sample of Chilean adolescents. Specific Aim 3 - To assess the role of circadian patterns of physical activity, sleep and eating behavior on adiposity and related metabolic disturbance. The long standing collaboration between the Institute for Nutrition and Technology at the University of Chile and the Center for Human Growth and Development at the University of Michigan provides an outstanding environment to study biological and psychosocial determinants of adolescent obesity in a low- to middle-income cohort of Latin American youth who are very similar in obesity risk to comparable U.S. youth. We expect to advance understanding of how developmental patterns of eating and activity are influenced by early life factors and in turn influence the development of obesity and related metabolic disturbance. Our study is unique in the depth and breadth of longitudinal psychosocial and biological data. We propose research that crosses disciplinary boundaries and has the potential to reveal important determinants of adolescent obesity for future intervention research.

描述（由申请人提供）：美国青少年肥胖症的流行率很高， 在拉丁美洲。食物和物理环境的急剧变化是 与风险增加相关，对个人，家庭的理解仍然不足 和保护肥胖发展的社区层面因素。进一步的研究是 需要了解导致低收入肥胖风险不同的机制 西班牙裔/拉丁裔青年。拟议的5年项目旨在阐明相互联系的生物学和 与青少年肥胖相关的社会道路和后来发展2型糖尿病的风险 和心血管疾病。该申请涉及大约620名智利青少年， 作为NIH支持的队列研究的一部分，在婴儿期进行了3至5年的评估。 预防婴儿贫血在婴儿期的行为和发育作用（n = 1645）。作为 已经收集了与增长，健康和发展有关的详细纵向数据。 16 到17年，年轻人将使用Actraphic参加活动，睡眠和饮食模式的研究 记录和实验室评估饮食行为。此外，我们将测量人体测量法， 脂肪和肌肉质量（DXA），禁食葡萄糖，胰岛素（HOMA IR），脂质，瘦素，生长素蛋白，脂联素， Orexin，CRP和TNF alpha。有关家族史，吸烟，健康和 还将收集社会心理功能。诸如犯罪，步行能力等邻里水平因素 将评估体育活动和健康食品属性的资源。此外， 带有睡眠神经生理学和精神分裂记录的大量子集（n = 237）在多个时间点 将在16年的时间参加2晚的多音乐睡眠研究。 在生命过程的指导下，我们建议调查三个具体目标： 具体目的1-评估肥胖和相关代谢的生物学和社会心理决定因素 自婴儿早期以来，一系列青少年的干扰。 特定目的2-评估肥胖/肥胖与肥胖相关的生物标志物之间的关联 智利青少年样本中的代谢干扰。 特定目标3-评估体育锻炼，睡眠和饮食行为的昼夜节律模式的作用 关于肥胖和相关代谢紊乱。 在营养与技术研究所之间的长期合作 智利大学和密歇根大学人类成长与发展中心 为研究青少年的生物学和社会心理决定因素提供了一个杰出的环境 在肥胖风险上非常相似的拉丁美洲青年中低至中等收入的肥胖 可比的美国青年。我们期望提高人们对饮食发展方式的理解 和活动受早期生命因素的影响，进而影响肥胖的发展 相关的代谢紊乱。我们的研究在纵向社会心理的深度和广度上是独一无二的 和生物数据。我们提出了跨越学科边界的研究，并有潜力 揭示青少年肥胖症的重要决定因素，以便将来的干预研究。