Quantification of breast density using dual energy mammography

使用双能乳房X线照相术定量乳房密度

• 批准号: 7738534
• 负责人: SABEE MOLLOI
• 金额: $ 31.73万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-24 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7738534
• 关键词: Adipose tissue; American; Area; Attenuated; Autopsy; Breast; Cause of Death; Dependence; Development; Goals; Human Volunteers; Image; Investigation; Magnetic Resonance Imaging; Malignant Neoplasms; Mammary Gland Parenchyma; Mammographic Density; Mammography; Measurement; Measures; Methods; Photons; Relative (related person); Relative Risks; Risk Factors; Screening procedure; Techniques; Testing; Thick; Tissues; Translating; Validation; Visual; Woman; attenuation; base; breast density; cancer risk; cone-beam computed tomography; density; malignant breast neoplasm; models and simulation; public health relevance

DESCRIPTION (provided by applicant): Among American women breast cancer is the most common cancer and the 2nd leading cause of death from cancer. Breast density, which is defined as the ratio of fibroglandular tissue to the total fibroglandular and adipose tissue, is an important risk factor in the development of breast cancer. A mammographically dense breast refers to a breast which attenuates a greater proportion of x-ray photons due to its significant volume fraction of fibroglandular tissue relative to adipose tissue. There are currently no accepted standards to reliably measure breast density. Subjective visual assessment alone is inadequate to quantify breast density. Other more quantitative attempts have suffered from a number of limitations such as providing only an area as opposed to volumetric measure of breast density or assuming a constant breast thickness. Previous studies have shown that the relative risk for developing breast cancer increases by 2% for every 1% increase in mammographic density, indicating the need for an accurate method to measure breast density. The goal of this proposal is to develop a method to objectively and quantitatively measure the density of a woman's breast using dual energy mammography. Dual energy imaging exploits the differential energy dependence in x-ray photon attenuation between fibroglandular and adipose tissue. Image pixels are decomposed into separate thickness measurements for each of the two primary breast tissues. The specific aims are: (1) Development of an analytical simulation model to investigate the feasibility of accurate breast density measurements using dual energy mammography. (2) Investigation of the hypothesis that breast density can be accurately measured in breast phantoms using dual energy mammography. (3) Validation of the dual energy technique for breast density quantification with magnetic resonance imaging (MRI) and cone-beam computed tomography in postmortem breast tissue. (4) To test the hypothesis that breast density measured in human volunteers with dual energy mammography and breast density measured with MRI have a correlation coefficient higher than 0.95. The proposed method provides a volumetric measure of breast density on a pixel by pixel basis and it has the potential to be incorporated into routine screening mammography. These advantages should translate into a more accurate assessment of breast cancer risk. The long-range plan for this project is to develop a clinically feasible method to measure the density of a woman's breast with dual energy x-ray mammography. PUBLIC HEALTH RELEVANCE: Breast density has been identified as an important yet underutilized risk factor in the development of breast cancer. Subjective visual assessment alone is inadequate to quantify breast density. The goal of this proposal is to develop a method to objectively and quantitatively measure the density of a woman's breast using dual energy mammography. The proposed method provides a volumetric measure of breast density and it has the potential to be incorporated into routine screening mammography.

描述（由申请人提供）：在美国女性中，乳腺癌是最常见的癌症，也是癌症死亡的第二大原因。乳腺密度定义为纤维腺组织与总纤维腺体和脂肪组织的比率，是乳腺癌发生的重要危险因素。乳房X线摄影致密乳房是指由于其纤维腺组织相对于脂肪组织的体积分数显着而衰减更大比例的X射线光子的乳房。目前还没有公认的标准来可靠地测量乳房密度。仅主观视觉评估不足以量化乳房密度。其他更定量的尝试受到了许多限制，例如仅提供面积而不是乳房密度的体积测量或假设乳房厚度恒定。此前的研究表明，乳腺X线密度每增加1%，患乳腺癌的相对风险就会增加2%，这表明需要一种准确的方法来测量乳腺密度。该提案的目标是开发一种使用双能乳房X线照相术客观定量测量女性乳房密度的方法。双能成像利用纤维腺体和脂肪组织之间 X 射线光子衰减的差异能量依赖性。图像像素被分解为两个主要乳房组织中每一个的单独的厚度测量值。具体目标是：（1）开发分析模拟模型，研究使用双能乳房X线照相术精确测量乳腺密度的可行性。 (2) 研究使用双能乳房X线照相术可以准确测量乳房模型中乳房密度的假设。 (3) 通过磁共振成像 (MRI) 和锥形束计算机断层扫描在死后乳腺组织中验证用于乳腺密度量化的双能量技术。 (4)检验双能乳腺X线摄影测量的人类志愿者乳腺密度与MRI测量的乳腺密度相关系数高于0.95的假设。所提出的方法提供了逐像素基础上乳腺密度的体积测量，并且有可能被纳入常规筛查乳房X线照相术中。这些优势应该转化为对乳腺癌风险的更准确的评估。该项目的长期计划是开发一种临床上可行的方法，通过双能 X 射线乳房X线照相术测量女性乳房的密度。公共卫生相关性：乳腺密度已被确定为乳腺癌发生的一个重要但未充分利用的危险因素。仅主观视觉评估不足以量化乳房密度。该提案的目标是开发一种使用双能乳房X线照相术客观定量测量女性乳房密度的方法。所提出的方法提供了乳腺密度的体积测量，并且有可能被纳入常规筛查乳房X光检查中。