Combinations of genetic and environmental risk for externalization in adolescence

青春期外化的遗传和环境风险的组合

基本信息

批准号：
7667242
负责人：
ERIC Nathan TURKHEIMER
金额：
$ 27.88万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-01 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7667242
关键词：
Accounting Acting Out Address Adolescence Adolescent Adolescent Development Alcohol or Other Drugs use Area Behavior Behavioral Behavioral Genetics Biologic Characteristic Biological Biometry Birth Characteristics Child Complex Confounding Factors (Epidemiology)Cross-Sectional Studies Data Data Set Demography Development Divorce Environment Environmental Risk Factor Epidemiology Equation Ethnic Origin Evaluation Exposure to Family Female Adolescents Genes Genetic Genetic Models Genetic Predisposition to Disease Genetic Research Genetic Structures Genotype Glean Goals Growth Hand Health Internet Intervention Investigation Knowledge Lead Linear Models Marital Status Markov Chains Marriage Maternal Age Measures Methods Modeling Monte Carlo Method Mothers Neighborhoods Non-linear Models Outcome Parenting behavior Parents Pathway interactions Peer Pressure Personal Satisfaction Phenotype Poverty Pregnancy Pregnancy in Adolescence Problem behavior Psychopathology Puberty Race Registries Research Research Design Research Personnel Risk Risk Factors Sex Behavior Siblings Social Development Social Environment Social Sciences Socioeconomic Status Solutions Specific qualifier value Spouses Statistical Methods Statistical Models Stress Supervision System Testing Time Twin Multiple Birth Virginia abortion adolescent offspring anti social base child poverty cohort depression design developmental psychology expectation externalizing behavior flexibility gene environment interaction genetic analysis high risk sexual behavior improved functioning interest model design motherhood novel offspring parental monitoring peer peer influence programs psychologic psychosocial pubertal timing public health relevance response social social model teenage mother theories transmission process

项目摘要

DESCRIPTION (provided by applicant): Although reliable associations have been established among a wide variety of social and biological precursors and risky, illegal, or psychopathological behavior in adolescence, the epidemiological and etiological details of how these factors combine remain to be understood in detail. Several extraordinarily detailed datasets are currently available, encompassing multiple cohorts, cultures and ethnicities. We propose to make use of unique and untapped potential in four existing datasets: The Australian Twin Registry, The Virginia 30,000, Add Health, and the Nonshared Environment and Adolescent Development project. Although the datasets all contain variables relevant to the explanation of disrupted development in adolescence, they have been collected with different emphases, ranging from the social and psychological to biological and genetic. The central theme of the current application is that family data, encompassing biological and social relations among parents and children, siblings, and twins, provides a unique window on the complex interplay of biological and social factors that combine in adolescent development. The application describes an integrated program of research combining the methodological and substantive expertise of a core group of investigators in behavioral genetics, developmental psychopathology, and social development in families. Throughout, our goal is to extend the limits of developmental social science in adolescence by employing genetically informative family data, while extending the scope of developmental behavioral genetics by getting beyond traditional variance partitioning approaches, applying genetically informative methods to the testing of specific questions about causal relations in complex developmental systems. Public Health Relevance: It is well-known that many aspects of family functioning and social environments like neighborhoods are associated with disrupted behavior in adolescence. In addition, there is a clear body of evidence demonstrating associations between biological characteristics of children and disrupted behavior. Both social and biological associations with problem behaviors in adolescence, however, can occur for at least two kinds of reasons, and it is crucial to be able to tell them apart. On the one hand it may be that the social or biological predictors actually cause the disrupted behavior; on the other hand, it could also turn out that the predictors are associated with the outcomes because of other factors. For example, if impoverished families provide less supervision to their children, and poverty also causes the children to be more likely to act out, lower supervision will be associated with acting out even though it does not cause it directly.

描述（由申请人提供）：尽管已经在各种社会和生物前兆与青春期的危险、非法或精神病理学行为之间建立了可靠的关联，但这些因素如何结合的流行病学和病因学细节仍有待详细了解。目前有几个非常详细的数据集，涵盖多个群体、文化和种族。我们建议利用四个现有数据集的独特且未开发的潜力：澳大利亚双胞胎登记处、弗吉尼亚 30,000、Add Health 以及非共享环境和青少年发展项目。尽管这些数据集都包含与解释青春期发育障碍相关的变量，但收集它们的侧重点不同，从社会和心理到生物和遗传。当前应用程序的中心主题是家庭数据，包括父母和孩子、兄弟姐妹和双胞胎之间的生物和社会关系，为了解青少年发展中生物和社会因素的复杂相互作用提供了一个独特的窗口。该申请描述了一个综合研究计划，结合了行为遗传学、发展精神病理学和家庭社会发展方面的核心研究小组的方法论和实质性专业知识。自始至终，我们的目标是通过利用遗传信息丰富的家庭数据来扩展青春期发育社会科学的局限性，同时通过超越传统的方差划分方法、应用遗传信息方法来测试有关因果关系的特定问题来扩展发育行为遗传学的范围。复杂发展系统中的关系。公共卫生相关性：众所周知，家庭功能和社区等社会环境的许多方面都与青春期的行为紊乱有关。此外，有大量证据表明儿童的生物学特征与行为紊乱之间存在关联。然而，与青春期问题行为的社会和生物学关联至少可能出于两种原因而发生，能够区分它们至关重要。一方面，可能是社会或生物预测因素实际上导致了行为紊乱；另一方面，由于其他因素，预测因素也可能与结果相关。例如，如果贫困家庭对孩子的监管较少，而贫困也导致孩子更容易发脾气，那么较低的监管就会与发脾气有关，尽管这不是直接原因。