Anthropometric Assessment of Abdominal Obesity and Health Risk in Children and Ad

儿童腹部肥胖和健康风险的人体测量评估和广告

• 批准号: 7832681
• 负责人: Peter Todd Katzmarzyk
• 金额: $ 50万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7832681
• 关键词: 18 year old; Abdomen; Address; Adipose tissue; Adolescent; Adult; African American; Age; Ambulatory Care Facilities; Anatomic Sites; Area; Biological; Biomedical Research; Body fat; Budgets; Caucasians; Caucasoid Race; Central obesity; Child; Childhood; Chronic Disease; Clinical; Clinical Research; Consensus; Country; Cross-Sectional Studies; Decision Making; Development; Dimensions; Early identification; Economics; Fatty acid glycerol esters; Funding; Goals; Health; Healthcare; Human body; Image; Imaging Techniques; Individual Differences; Intra-abdominal; Laboratories; Limb structure; Magnetic Resonance Imaging; Measurement; Measures; Metabolic Diseases; Methodology; Methods; Obesity; Occupations; Participant; Pediatric Research; Population; Positioning Attribute; Prevalence; Procedures; Protocols documentation; Public Health; Race; Recruitment Activity; Research; Research Design; Resources; Risk; Risk Factors; Sampling; Standardization; Stream; Techniques; Time; Umbilicus; Visceral; abdominal fat; boys; cost effective; disorder risk; experience; girls; indexing; obesity in children; public health relevance; racial difference; rib bone structure; sex; subcutaneous; surveillance strategy; waist circumference

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (04) Clinical Research, and Specific Challenge Topic 06- DK-106: Identifying a Standard Anthropometric Measure for Pediatric Central Adiposity. Abdominal fat, in particular intra-abdominal visceral adipose tissue is considered to be the most dyslipidemic and atherogenic fat depot in the human body. Intra-abdominal visceral adipose tissue and total body fat can be measured precisely and reliably in a laboratory setting using advanced imaging techniques; however, reliable clinical measurements of pediatric intra-abdominal visceral adipose tissue and total body fat are yet to be developed. Early identification is essential to addressing the expanding problem of pediatric obesity and metabolic disease. Thus, the specific aims of this study are to 1) identify reliable landmarks and methodology for the measurement of pediatric waist circumference that are associated with intra-abdominal visceral adipose tissue and total body fat across the pediatric age (5 to 18 years of age), total body adiposity, and biological maturity range among African American and Caucasian children and adolescents, 2) determine if waist circumference in combination with other anthropometric indices is a better predictor of intra-abdominal visceral adipose tissue and total body fat than waist circumference alone across the pediatric age, total body adiposity, and maturation range, and 3) develop and determine the clinical utility of pediatric race-sex-specific waist circumference thresholds for the identification of elevated chronic disease risk factors across the pediatric age, total body adiposity, and maturation range. We will accomplish these aims by conducting a cross-sectional study of 100 African American boys, 100 Caucasian boys, 100 African American girls, and 100 Caucasian girls 5 to 18 years of age. Waist circumference will be measured at the four common anatomic sites used in pediatric research: 1) superior border of the iliac crest, 2) midpoint between the iliac crest and the lowest rib, 3) umbilicus, and 4) minimal waist. Additional body dimensions will be obtained in order to determine the clinical utility of combining waist circumference with other measurements in predicting intra-abdominal visceral adipose tissue and total body fat, which will be assessed using advanced imaging techniques. The identification of the most appropriate waist circumference landmarks and measurement techniques is important for the clinical identification of children at elevated obesity-related health risk and for the standardization of obesity surveillance strategies within and between countries. PUBLIC HEALTH RELEVANCE (provided by applicant): Childhood obesity is a major public health issue, and the identification of children who are at increased risk of health problems due to their obesity is a priority for modern health care. Abdominal fat is considered to be the most harmful in the body, and the development of reliable landmarks and procedures for the assessment of intra-abdominal visceral adipose tissue and total body fat in children will have a major impact on 1) the early identification of children at elevated health risk, 2) the proper prioritization of health care resources, and 3) the standardization of obesity surveillance procedures within and between countries.

描述（由申请人提供）：此申请涉及广泛的挑战领域（04）临床研究和特定挑战主题06- DK-106：确定针对小儿中央肥胖的标准人体测量指标。腹部脂肪，尤其是腹内内脏脂肪组织被认为是人体中血脂性最高和动脉粥样硬化脂肪库。在实验室环境中，使用先进的成像技术可以精确，可靠地测量腹内内脏脂肪组织和总体脂肪；但是，小儿腹内内脏脂肪组织和总体脂肪的可靠临床测量尚待开发。早期鉴定对于解决小儿肥胖和代谢疾病的扩大问题至关重要。因此，这项研究的具体目的是1）确定可靠的地标和方法，用于测量与腹腔内的内脏脂肪组织和整个小儿年龄（5至18岁）（5至18岁），全身肥胖度和生物学范围之间的宽敞范围以及其他确定的儿童和持续性范围2的儿科腰围和整个体内脂肪有关的小儿腰围和方法。人体测量指标是对腹内内脏脂肪组织和总体脂肪的更好预测指标，而与腰围相比，在小儿年龄，全身肥胖，成熟范围和成熟范围和3）发展并确定儿科特异性种族特异性的腰围脱粒率相对于经过高度识别的高度经常性疾病的临床效果 范围。我们将通过对100名非洲裔美国男孩，100名高加索男孩，100名非裔美国女孩和100名5至18岁的白种女孩进行横断面研究来实现这些目标。腰围将在儿科研究中使用的四个常见解剖部位进行测量：1）iLiac Crest的上边界，2）iLiac Crest和最低肋骨之间的中点，3）脐带和4）最小腰部。将获得其他身体尺寸，以确定将腰围与其他测量结果相结合的临床实用性，以预测腹内内脏脂肪组织和总体脂肪，这将使用先进的成像技术进行评估。鉴定最合适的腰围地标和测量技术对于在与肥胖相关的健康风险升高的临床鉴定以及国家内部和国家之间肥胖监测策略的标准化方面非常重要。 公共卫生相关性（由申请人提供）：儿童肥胖是一个主要的公共卫生问题，并且确定由于肥胖而导致健康问题风险增加的儿童是现代医疗保健的优先事项。腹部脂肪被认为是体内最有害的，并且开发可靠的地标和程序来评估腹内内脏脂肪组织和儿童的全身脂肪将对1）对健康升高的儿童的早期识别产生重大影响。