Pediatric HIV Treatment Strategies

儿童艾滋病毒治疗策略

• 批准号: 7900781
• 负责人: Kiat Ruxrungtham
• 金额: $ 5.88万
• 依托单位: HIV-NAT, THE THAI RED CROSS AIDS RCH CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7900781
• 关键词: Acquired Immunodeficiency Syndrome; Adult; Adverse effects; Anti-Retroviral Agents; Cambodia; Caring; Child; Childhood; Clinical; Commit; Country; Development; Diabetes Mellitus; Disease; Dyslipidemias; Equilibrium; Evaluation; Family; Guidelines; HIV; HIV Infections; Health; Health Services Accessibility; Highly Active Antiretroviral Therapy; International; Lactic Acidosis; Life; Lipodystrophy; Mitochondria; Morbidity - disease rate; Outcome; Public Health; Quality of life; Reporting; Research; Resistance; Resources; Thailand; Time; Toxic effect; antiretroviral therapy; mortality; pediatric human immunodeficiency virus; programs; treatment strategy

Worldwide, there are over one million children with HIV infection. 41At year-end 2000, the Thai Ministry of Public Health (MOPH) reported 20,052 and 2, 332 cases of children living with HIV and AIDS respectively, and 4,185 newly infected childrenC-The use of highly active antiretroviral therapy (HAART) has resulted in a significant reduction of morbidity and mortality among adults and children with HIV infection. 4344Nevertheless, few children have access to treatment and care for HIV disease, and less than 1% of children are on effective ARV therapy. Applicability of this study to both resource-rich and resource-limited settin.qs In resource-limited countries such as Thailand where ARV treatment for HIV-infected children according to international and national guidelines is not affordable, mechanisms for selecting groups of children to receive ARV treatment are needed. In resource-rich countries where the majority of children have access to care, the initiation of ARV therapy, if sooner than needed, can result in unnecessary morbidity. Once begun on ARV therapy, children are committed to life-long treatment. The use of ARV therapy can be associated with significant morbidity, namely toxicity and development of virological resistance. Lipodystrophy, dyslipidaemia and diabetes mellitus are examples of side effects that can result 45 4647 in poor health and quality of life. Lactic acidosis and mitochondrial toxicity are potentially life-threatening side effects 4649Successful treatment with ARV in children requires high-level compliance, which is not an easy task, and can be stressful for families and the children themselves.so As there is currently no cure for HIV infection, a balance between treating the disease and maintaining good health and quality of life must be weighed carefully. We believe that for both resource-rich and resource-limited settings, an evaluation of the appropriate time of initiation of ARV therapy is needed. The treatment strategy of deferred ARV therapy must be evaluated.

在全球范围内，有超过一百万的艾滋病毒感染儿童。 41年年底2000年，泰国公共卫生部（MOPH）分别报道了20,052和2，332例分别为艾滋病毒和艾滋病患儿童，以及4,185例新感染的儿童 - 使用高度活跃的抗逆转录病毒疗法（HAART），导致了成年成年成年人和HIV及HIV的儿童的大量降低。 4344不过，很少有儿童能够获得HIV疾病的治疗和护理，不到1％的儿童正在接受有效的ARV治疗。 这项研究适用于资源丰富和资源有限的Settin.qs 在诸如泰国等资源有限的国家中，根据国际和国家准则，根据国际和国家指南对艾滋病毒感染儿童的治疗是不起作用的，需要选择儿童群体接受ARV治疗的机制。 在资源丰富的国家，大多数儿童都可以接受护理，如果比需要的话，ARV治疗的启动可能会导致不必要的发病率。一旦开始接受ARV治疗，儿童就致力于终身治疗。 ARV治疗的使用可能与明显的发病率有关，即毒性和病毒学耐药性的发展。脂肪营养不良，血脂异常和糖尿病是副作用的例子，可能导致 45 4647的健康和生活质量。乳酸性酸中毒和线粒体毒性可能是威胁生命的副作用4649取得成功的儿童治疗需要高级依从性，这不是一件容易的事，这对家庭和儿童本身可能会充满压力。因此，由于目前对HIV感染没有治疗，因此对疾病和维持良好的健康和质量保持良好的健康和维持良好的健康状况，因此无法治愈。 我们认为，对于资源丰富和资源有限的设置，都需要评估适当的ARV治疗时间。必须评估递延ARV治疗的治疗策略。