Treatment of HIV/Tuberculosis Co-Disease

HIV/结核病合并疾病的治疗

• 批准号: 7900782
• 负责人: Kiat Ruxrungtham
• 金额: $ 5.88万
• 依托单位: HIV-NAT, THE THAI RED CROSS AIDS RCH CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7900782
• 关键词: Anti-Retroviral Agents; Cambodia; Clinical; Clinical Management; Disease; HIV; HIV therapy; Immunologic Deficiency Syndromes; Infection; Inpatients; Methods; Newly Diagnosed; Outcome; Outpatients; Patients; Pharmaceutical Preparations; Phase; Randomized; Research; Safety; System; Testing; Thailand; Tuberculosis; Upper arm; antiretroviral therapy; chemotherapy; improved; open label; programs; tuberculosis treatment

Objectives To conduct a randomised, open label study to test whether a strategy of initiation of antiretroviral therapy shortly after commencing tuberculosis chemotherapy (2 weeks) achieves a significantly improved outcome when compared to a strategy in which antiretroviral therapy is deferred until the induction phase is complete (2 months) Specific aims ¿ To evaluate the efficacy, safety and tolerability of two strategies for the management of HIV related TB disease ¿ To improve the clinical management of patients with HIV/TB co-disease ¿ To establish a system of direct observation of therapy for HIV related TB Methods ¿ The study will be conducted in both inpatient and outpatient settings in Thailand and Cambodia. ¿ All patients newly diagnosed with first episode tuberculosis and co-infected with HIV will receive standardised TB short-course chemotherapy. ¿ Patients will be randomised to receive antiretroviral therapy to commence either early in the course of tuberculosis treatment (at two weeks) or deferred until TB therapy has been completed (at two months). ¿ Patients in both arms will receive the same combination of antiretroviral drugs

目标 进行随机的开放标签研究，以测试抗逆转录病毒疗法的策略是否存在 开始结核化疗（2周）后不久，取得了显着改善的结果 与抗逆转录病毒疗法的策略相比，直到诱导阶段完成 （2个月） 具体目标 �评估两种策略用于管理HIV相关结核病的效率，安全性和容忍性 疾病 »改善HIV/TB共疾病患者的临床管理 �建立直接观察HIV相关结核病治疗的系统 方法 这项研究将在泰国和柬埔寨的住院和门诊环境中进行。 �所有新诊断出患有第一集结核病并与HIV共同感染的患者将接受 标准化结核病疗程化疗。 �患者将随机接受抗逆转录病毒疗法，以便在早期开始 结核病治疗（两周后）或推迟到结核病治疗完成（两个月后）。 两臂中的患者将接受相同的抗逆转录病毒药物的组合