Sleep and Adiposity: A Prospective Twin Study

睡眠与肥胖：一项前瞻性双胞胎研究

• 批准号: 7672283
• 负责人: Xin Liu
• 金额: $ 50.38万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7672283
• 关键词: 21 year old; Adolescence; Adolescent; Age; Area; Arts; Behavioral Genetics; Biological; Biological Markers; Blood Pressure; Centers for Disease Control and Prevention (U.S.); Child; China; Chinese People; Clinical; Country; Data; Data Collection; Desire for food; Dietary Questionnaires; Enrollment; Environmental Exposure; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Fasting; Fatty acid glycerol esters; Food Hypersensitivity; Foundations; Funding; Future; Gender; Genetic; Gestational Age; Glucose; Goals; Health; Height; Hip region structure; Hydrocortisone; Inflammation; Insulin; Insulin-Like Growth Factor I; Interleukin-6; Intervention; Laboratories; Leptin; Life; Link; Lipids; Longitudinal Studies; Measures; Mediating; Metabolic syndrome; Metabolism; Methods; Modeling; National Institute of Child Health and Human Development; Neurosecretory Systems; Nutritional status; OGTT; Obesity; Overweight; Pathway interactions; Personal Satisfaction; Phenotype; Physical activity; Pregnancy Complications; Prospective Studies; Questionnaires; Reporting; Research Design; Research Personnel; Resources; Sample Size; Sleep; Societies; Socioeconomic Status; Staging; Testing; Time; Twin Multiple Birth; Twin Studies; Weight; actigraphy; adiponectin; age effect; age group; aged; cohort; cost; design; diaries; follow-up; ghrelin; heart rate variability; high risk; mother nutrition; obesity in children; obesity risk; programs; prospective; socioeconomics; young adult

DESCRIPTION (provided by applicant): The goal of our proposed study is to elucidate cause-and-effect relationships and mechanisms that link short sleep duration (SSD) and overweight or obesity (OWO) in children, adolescents, and young adults using a large existent prospective twin cohort. We enrolled about 2,000 twin pairs in 1998-2000 in Anqing, China, when the twins were 6-21 years of age. This twin cohort is being followed (1st F/U) by a NICHD funded study (R01HD049059) to identify precursors of metabolic syndrome (MS). The second follow-up (2nd F/U) will begin in 2007 (approximately 2 years after 1st F/U) with support from the Food Allergy Foundation. Relevant data that are being or will be collected at the 1st and 2nd F/U include epidemiologic and dietary questionnaires, anthropometric measures (height, weight; waist and hip circumferences), Tanner Stages, MS phenotypes [total and truncal fat, blood pressure, fasting lipids, fasting and 2-hr post OGTT insulin and glucose), biomarkers (IGF-1, adiponectin, IL-6, TNF-a), Zygosity, and sleep data (questionnaire, 7 day diary, and actigraphy). This proposal seeks support to accomplish the following aims: (1) to measure biomarkers along the major pathways that link SSD with OWO, including Autonomic & Neuroendocrine Function (heart rate variability, cortisol); Inflammation (CRP); and Appetite (leptin, ghrelin) at the 1st and the 2nd follow-up. We will also examine other relevant biomarkers already covered by the funded studies; (2) To conduct cross-sectional and prospective co-twin analyses to determine SSD-OWO relationships; relationships between the biomarkers and OWO; and to examine if the above relationships are genetically mediated and test the modifying effects of age, gender, Tanner stage, physical activity and nutritional status; and (3) To examine whether SSD-OWO relationships are mediated by the biomarkers. The unique opportunities offered by this Chinese twin cohort are: (1) the prospective study design can assess temporal relationships and provide strong evidence for cause-and-effect; (2) the large sample size assures our ability to detect causal associations, unlike most studies in this area, which are underpowered; (3) the co-twin design, in which numerous potential confounding factors-including age, gestational age, pregnancy complications, maternal nutrition, environmental exposure, and parental socioeconomic status-are precisely matched, can minimize confounding in analysis of SSD-OWO associations; (4) the MZ and DZ co-twin models can efficiently partition environmental and genetic contributions to the SSD-OWO relationship; (5) the cost of data collection is largely covered by other funded studies; and (6) the ability to study age groups at particularly high risk for OWO, in which intervention has the greatest potential for life-long improvements in health and well-being. This twin cohort is also a precious resource for future longitudinal studies of sleep and OWO.

描述（由申请人提供）： 我们提出的研究的目的是利用现有的大型前瞻性双胞胎队列，阐明儿童、青少年和年轻人睡眠时间短 (SSD) 与超重或肥胖 (OWO) 之间的因果关系和机制。 1998年至2000年，我们在中国安庆招募了约2000对双胞胎，当时双胞胎的年龄为6至21岁。 NICHD 资助的一项研究 (R01HD049059) 正在对这对双胞胎队列进行追踪（1st F/U），以识别代谢综合征 (MS) 的先兆。第二次随访（第 2 次 F/U）将于 2007 年（第 1 次 F/U 后约 2 年）开始，并得到食物过敏基金会的支持。正在或将在第 1 次和第 2 次 F/U 收集的相关数据包括流行病学和饮食调查问卷、人体测量数据（身高、体重、腰围和臀围）、Tanner 阶段、MS 表型 [总脂肪和躯干脂肪、血压、空腹血脂、空腹和 OGTT 后 2 小时胰岛素和葡萄糖）、生物标志物（IGF-1、脂联素、IL-6、 TNF-a）、接合性和睡眠数据（问卷、7 天日记和体动记录仪）。该提案寻求支持以实现以下目标：(1) 测量连接 SSD 与 OWO 的主要途径的生物标志物，包括自主和神经内分泌功能（心率变异性、皮质醇）；炎症（CRP）；以及第一次和第二次随访时的食欲（瘦素、生长素释放肽）。我们还将检查资助研究已涵盖的其他相关生物标志物； (2) 进行横断面和前瞻性双孪生分析以确定 SSD-OWO 关系；生物标志物与OWO之间的关系；并检查上述关系是否是遗传介导的，并测试年龄、性别、坦纳阶段、体力活动和营养状况的改变作用； (3) 检查 SSD-OWO 关系是否由生物标志物介导。这个中国双胞胎队列提供的独特机会是：（1）前瞻性研究设计可以评估时间关系并为因果关系提供强有力的证据； （2）大样本量确保了我们检测因果关系的能力，这与该领域的大多数研究不同，这些研究的力度不足； （3）联合双胞胎设计，其中许多潜在的混杂因素——包括年龄、胎龄、妊娠并发症、孕产妇营养、环境暴露和父母的社会经济地位——精确匹配，可以最大限度地减少SSD-OWO关联分析中的混杂因素; (4) MZ和DZ双孪生模型可以有效划分环境和遗传对SSD-OWO关系的贡献； (5) 数据收集的费用大部分由其他资助的研究承担； (6) 研究 OWO 风险特别高的年龄组的能力，其中干预最有可能改善终生健康和福祉。这个双胞胎队列也是未来睡眠和 OWO 纵向研究的宝贵资源。