The Alzheimer's Disease Clinical and Translational Research (ADCTR) Training Program

阿尔茨海默病临床和转化研究 (ADCTR) 培训计划

• 批准号: 9977904
• 负责人: Chunyu Wang
• 金额: $ 30.03万
• 依托单位: RENSSELAER POLYTECHNIC INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9977904
• 关键词: Alzheimer' s Disease; Clinical Research; Training Programs; Translational Research

This is a new proposal for the Alzheimer's Disease Clinical and Translational Research (ADCTR) Training Program at Rensselaer Polytechnic Institute (RPI) in collaboration with the Icahn School of Medicine at Mount Sinai (ISMMS). Our objectives are aimed at increased interaction among students from the three schools (Architecture, Engineering and Science) and four PhD granting departments (Biomedical Engineering, Biological Sciences, Chemical Engineering and Chemistry) as well as four Institute-wide centers (Center for Biotechnology and Interdisciplinary Studies (CBIS), Lighting Research Center (LRC), Institute of Data Exploration and Application (IDEA) and Severino Center for Technological Entrepreneurship) as well as the Department of Computer Science and the Lally School of Management at RPI. The Ronald M. Loeb Center for Alzheimer's Disease at Icahn School of Medicine at ISMMS and industry partners will provide short term training/research projects in AD and AD-related dementias. This Training Program will provide trainees with a keen understanding of the interdisciplinary, clinical and translational nature of research on Alzheimer's disease and related dementias, how it depends on fundamental underpinnings of both science and engineering, how it leads to innovative new scientific disciplines and technologies, how it can be applied to clinical settings, and how commercial products are developed. Faculty from these programs are actively involved in research programs spanning the following: 1) pharmacologic and non-pharmacologic interventions for Alzheimer's disease and neurodegenerative disease; 2) biomarkers and imaging; and 3) structural biology of protein folding/tau. Key aspects of the training program will include: [1] a set of four courses that will maximize didactic training among the key disciplines; [2] a core course entitled “Perspectives in Alzheimer's Disease Research” that will be taken by all trainees; [3] a seminar series and research symposia that will build on campus-wide programs at RPI and its clinical and industry partners; [4] a student-run seminar program, in which trainees present their research to their peers and training faculty; [5] training in responsible conduct of research; [6] joint supervision (at least 2 mentors spanning disciplines per trainee) and a multidisciplinary thesis committee membership for Ph.D. thesis work in architecture, science and engineering; [7] industrial and/or clinical externships; [8] poster presentation and participation in the annual meeting of the CBIS and LRC Industry Partners Program; [9] entrepreneurship and commercial translation training; and [10] an annual retreat in contemporary research in Alzheimer's Disease and related dementias at which trainees and others on campus interact with outside researchers in the field. An Executive Committee will ensure that trainees satisfy Program requirements and an Underrepresented Minority Recruitment (URM) Committee will actively engage in, identify and recruit a diverse student population into the program. In addition to the six trainee slots per year proposed herein, Rensselaer will support two Institute trainees per year.

这是阿尔茨海默氏病临床和转化研究（ADCTR）培训的新建议 伦斯勒理工学院（RPI）的计划与Mount的伊坎医学院合作 西奈（ISMMS）。我们的目标旨在增加三所学校的学生之间的互动 （建筑，工程和科学）以及四个博士学位授予部门（生物医学工程， 生物科学，化学工程和化学）以及四个范围内的中心（中心 生物技术和跨学科研究（CBIS），照明研究中心（LRC），数据研究所 探索和应用（想法）和Severino技术创业中心）以及 RPI计算机科学系和Lally管理学院。罗纳德·M·勒布（Ronald M. Loeb） ISMMS和行业合作伙伴的ICAHN医学院的阿尔茨海默氏病将提供短期 培训/与广告相关痴呆症的培训/研究项目。该培训计划将为受训者提供 敏锐地了解阿尔茨海默氏病研究的跨学科，临床和翻译性质 和相关的痴呆症，这如何取决于科学和工程的基本基础，它如何 导致创新的新科学学科和技术，如何应用于临床环境以及 商业产品的开发方式。这些计划的教师积极参与研究 涵盖以下程序：1）阿尔茨海默氏症的药理学和非药物干预措施 疾病和神经退行性疾病； 2）生物标志物和成像； 3）结构生物学 蛋白质折叠/tau。培训计划的关键方面将包括：[1]一组四门课程 在关键学科中最大化教学培训； [2]核心课程，名为“阿尔茨海默氏症的观点 疾病研究”将由所有培训进行； [3]开创性的系列和研究研讨会将建立 在RPI及其临床和行业合作伙伴的校园范围内； [4]一项学生经营的节目课程， 哪些受训者向同龄人和培训教师介绍他们的研究； [5]负责任的培训 研究; [6]联合监督（至少有2位跨学科的导师）和一个多学科 博士学位论文委员会会员资格论文在建筑，科学和工程学中的工作； [7]工业 和/或临床实质性； [8]海报演示和参加CBI的年度会议和参与 LRC行业合作伙伴计划； [9]创业和商业翻译培训；和[10]一年 在当代研究的阿尔茨海默氏病和相关痴呆症中的研究中，学员和其他人的痴呆症 在校园里，与该领域的外部研究人员互动。执行委员会将确保学员 满意计划要求和代表性不足的少数族裔招聘（URM）委员会将积极积极 参与，识别和招募潜水员的学生群体参与该计划。除了六个实习老虎机 本文提议的每年，伦斯勒将支持每年两名学院学员。