Q-TOF Ion Mobility Mass Spectrometer for Drug Discovery

用于药物发现的 Q-TOF 离子淌度质谱仪

• 批准号: 7591902
• 负责人: MICHAEL GRIFFITH BARTLETT
• 金额: $ 50万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7591902
• 关键词: Anti-Bacterial Agents; Antineoplastic Agents; Area; Cancer Biology; Carbohydrates; Complex; Core Facility; Equipment; Funding; Glycoproteins; Grant; Hybrids; Lipids; Mass Spectrum Analysis; Natural Product Drug; Pharmaceutical Chemistry; Pharmacy facility; Research; Research Support; System; Time; United States National Institutes of Health; Universities; Viral; college; drug discovery; improved; instrument; ion mobility; mass spectrometer; nervous system disorder; programs; public health relevance; tool

DESCRIPTION (provided by applicant): This application covers the acquisition of a quadrupole time-of-flight (Q-TOF) ion mobility hybrid mass spectrometer. This instrument will be added to an existing core facility in the University of Georgia, College of Pharmacy and be directly involved in supporting research efforts by the College of Pharmacy and two major university centers the Center for Drug Discovery and the Complex Carbohydrate Research Center. The introduction of a Q-TOF Ion Mobility MS system would bring several unique advantages over our existing mass spectrometry equipment. These advantages include: (1) improved separations; (2) high mass accuracy for MS/MS; (3) identification of glycoproteins; (4) lipid analysis; (5) and improved sensitivity. These benefits make the Q-TOF Ion Mobility MS system an extremely powerful tool for drug discovery. There are seven major users of the equipment representing many significant NIH grants. Their projects cover the areas of synthetic medicinal chemistry of anti-viral and antibacterial agents, natural products drug discovery for anti-cancer agents, cancer biology, drug discovery for neurological disorders glycomics and lipodomics. PUBLIC HEALTH RELEVANCE: This application covers the purchase of a mass spectrometer to enhance existing NIH research programs in drug discovery. This instrument dramatically enhances an existing core facility and will directly contribute to the research of seven major NIH funded users.

描述（由申请人提供）：本申请涵盖四极飞行时间 (Q-TOF) 离子淌度混合质谱仪的采购。该仪器将添加到佐治亚大学药学院现有的核心设施中，并直接参与支持药学院和两个主要大学中心（药物发现中心和复杂碳水化合物研究中心）的研究工作。 Q-TOF 离子淌度 MS 系统的引入将给我们现有的质谱设备带来一些独特的优势。这些优点包括： (1) 改进的分离； (2) MS/MS 的质量精度高； (3)糖蛋白的鉴定； (4)血脂分析； (5)灵敏度提高。这些优点使 Q-TOF 离子淌度 MS 系统成为药物发现的极其强大的工具。该设备有七个主要用户，代表了 NIH 的许多重要拨款。他们的项目涵盖抗病毒和抗菌药物的合成药物化学、抗癌药物天然产物药物发现、癌症生物学、神经系统疾病糖组学和脂质组学药物发现等领域。公共健康相关性：本申请涵盖购买质谱仪以增强 NIH 现有药物发现研究项目。该仪器极大地增强了现有的核心设施，并将直接为 NIH 资助的七个主要用户的研究做出贡献。