Diabetes and Persistent Organic Pollutants

糖尿病和持久性有机污染物

• 批准号: 7921558
• 负责人: Mary Ellen Turyk
• 金额: $ 18.95万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7921558
• 关键词: Adipose tissue; Age; Aging; Antibodies; Biological Markers; Body mass index; C-reactive protein; Chemicals; Confounding Factors (Epidemiology); Cross-Sectional Studies; Data; Development; Diabetes Mellitus; Diabetes prevention; Diagnosis; Dioxins; Disease; Endocrine; Environmental Exposure; Environmental Pollutants; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Ethers; Exclusion; Exposure to; Fishes; Future; Gender; General Population; Genetic; Glutamate Decarboxylase; Glycosylated hemoglobin A; Goals; Health Status; Incidence; Investigation; Knowledge; Length; Measurement; Measures; Mediator of activation protein; Metabolism; Modification; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Occupational Exposure; Participant; Persons; Pesticides; Polybrominated Biphenyls; Polychlorinated Biphenyls; Population; Prevalence; Prospective Studies; Research; Risk; Risk Factors; Role; Sampling; Serum; Sports; Testing; Time; Transferase; Triglycerides; Work; adiponectin; cohort; diabetes risk; dibenzo(1,4)dioxin; dichlorodiphenyltrichloroethane; environmental agent; environmental chemical; exposed human population; follow-up; high risk; insight; modifiable risk; pollutant; prospective; public health relevance

DESCRIPTION (provided by applicant): Diabetes is related to both genetic and environmental factors. While obesity and physical inactivity are dominant etiologic factors, exposure to environmental chemicals may also contribute to risk. Persistent organic pollutants (POPs) such as dioxins, polychlorinated biphenyls (PCBs), p,p'-diphenyldichloroethene (DDE), and polybrominated biphenyl ethers (PBDEs) are detectable in most of the US population. Recently, general population exposures to POPs, such as dioxins, PCBs, and DDE, have been associated with type 2 diabetes in several cross sectional studies and PCBs were associated with diabetes in one prospective study. The proposed project will build upon 15 years of research observation of a POP-exposed, aging cohort of Great Lakes sport fish consumers, who are at higher risk of exposure to PCBs and related compounds. POPs were measured in 947 participants at various times between 1994 and 2005. Follow up of 471 participants shows a strong association of DDE with incident diabetes. The new study will expand data on confounding variables and extend follow up of the cohort for incident diabetes, increasing the number of incident cases and the power to detect effects of PBDEs and gender specific effects of DDE and PCBs; evaluating effect modification among multiple exposures and adiposity; and determining if the association of DDE and diabetes remains significant in participants with incident diabetes more than 10 years after exposure measurements. Associations of POPs with biomarkers of diabetes risk will be investigated by testing banked serum samples for adiponectin, C reactive protein, glutamic acid decarboxylase antibodies, and 3-glutamyl transferase. The proposed research allows for efficient follow up of important findings in a well defined cohort, and will provide insight into promising avenues for future epidemiologic and toxicologic investigations on the effect of environmental exposures on diabetes. It will be the first prospective diabetes study for DDE and PBDE exposure and will be the first study of to investigate biomarkers of diabetes risk and DDE exposure. Given the ubiquitous exposure of human populations to POPs and the increasing incidence of diabetes, investigations that further delineate the role of these potentially modifiable environmental agents are important for prevention of diabetes. PUBLIC HEALTH RELEVANCE: Project Narrative This investigation will study the effect of exposure to environmental pollutants on development of diabetes. The chemicals under study are polychlorinated biphenyls (PCBs), dioxins, polybrominated biphenyl ethers (PBDEs), and p,p'-diphenyldichloroethene (DDE), a metabolite of the pesticide DDT (dichlorodiphenyltrichloroethane). It is important to find out if exposure to persistent pollutants is related to the development of diabetes because most of the population is exposed to small amounts of these chemicals.

描述（由申请人提供）：糖尿病与遗传和环境因素有关。尽管肥胖和身体不活动是主要的病因因素，但对环境化学物质的接触也可能导致风险。在大多数美国人群中，可检测到持续的有机污染物（POP），例如二恶英，多氯联苯（PCB），P，P'-二苯基二氯乙烯（DDE）和多溴化的双苯基乙醇（PBDE）。最近，在一项前瞻性研究中，在几项横截面研究中，普通人群暴露于POPS，例如二恶英，PCB和DDE，与2型糖尿病有关，PCB与糖尿病有关。拟议的项目将建立在15年的研究观察结果的基础上，对大湖区运动式鱼类消费者的衰老队列，他们面临PCB和相关化合物的风险更高。在1994年至2005年之间的不同时间，在947名参与者中测量了POPS。对471名参与者的跟进表明，DDE与入射糖尿病有很强的关联。这项新的研究将扩大有关混杂变量的数据，并扩展对入射糖尿病的队列的随访，增加事件病例的数量以及检测PBDES效应以及DDE和PCB的性别特定效应的能力；评估多种暴露和肥胖之间的效果修改；并确定在暴露测量后10年以上的10年以上的参与者中，DDE和糖尿病的关联是否仍然显着。通过测试脂联素，C反应性蛋白，谷氨酸脱羧酶抗体和3-谷氨酰胺转移酶的库血清样品，将研究与糖尿病风险的POP与糖尿病风险的关联。拟议的研究允许在定义明确的队列中有效地跟进重要发现，并将洞悉未来的流行病学和毒理学研究对环境暴露对糖尿病的影响的途径。这将是DDE和PBDE暴露的第一项前瞻性糖尿病研究，它将成为研究糖尿病风险和DDE暴露生物标志物的首次研究。鉴于人类人群无处不在地暴露于POP和糖尿病的发生率的增加，因此进一步描述这些潜在可修改的环境药物的作用的研究对于预防糖尿病很重要。公共卫生相关性：项目叙述这项调查将研究暴露于环境污染物对糖尿病发展的影响。所研究的化学物质是多氯联苯（PCB），二恶英，多溴二苯基醚（PBDES）和P，P，P'-Diphenyldichloroethene（DDE），一种农药DDT（二氯二苯基二苯基甲基甲基氯乙烷）。重要的是要确定暴露于持续污染物是否与糖尿病的发展有关，因为大多数人群都暴露于少量这些化学物质。

项目成果

Longitudinal biomonitoring for polybrominated diphenyl ethers (PBDEs) in residents of the Great Lakes basin.

• DOI: 10.1016/j.chemosphere.2010.07.037
• 发表时间: 2010-09
• 期刊: Chemosphere
• 影响因子: 8.8
• 作者: Turyk ME;Anderson HA;Steenport D;Buelow C;Imm P;Knobeloch L
• 通讯作者: Knobeloch L

Uterine leiomyomata in a cohort of Great Lakes sport fish consumers.

• DOI: 10.1016/j.envres.2011.01.006
• 发表时间: 2011-05
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Lambertino A;Turyk M;Anderson H;Freels S;Persky V
• 通讯作者: Persky V

Persistent organic pollutants and biomarkers of diabetes risk in a cohort of Great Lakes sport caught fish consumers.

• DOI: 10.1016/j.envres.2015.03.037
• 发表时间: 2015-07
• 期刊: ENVIRONMENTAL RESEARCH
• 影响因子: 8.3
• 作者: Turyk, Mary;Fantuzzi, Giamila;Persky, Victoria;Freels, Sally;Lambertino, Anissa;Pini, Maria;Rhodes, Davina H.;Anderson, Henry A.
• 通讯作者: Anderson, Henry A.