Cohort Study of Cancer-Inhibitory Dietary Factors in Men

男性癌症抑制饮食因素的队列研究

基本信息

批准号：
7630383
负责人：
XIAO-Ou SHU
金额：
$ 61.49万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-07-01 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7630383
关键词：
Address Adult Allium Vegetable American Antibodies Asians Baseline Surveys Biological Biological Markers Blood C-reactive protein Cancer Etiology Carbohydrates Cells Cessation of life Chinese People Cohort Studies Collection Colon Carcinoma Colorectal Colorectal Cancer Consumption Country Data Diet Dietary Component Dietary Factors Dietary intake Doctor of Medicine Doctor of Philosophy Dose Enrollment Epidemiologic Studies Etiology Evaluation Fatty acid glycerol esters Fiber Folate Food Funding Future Grant Hand Helicobacter pylori Human In Vitro Incidence Intake Interview Isothiocyanates Knowledge Life Lung Malignant Neoplasms Malignant neoplasm of lung Measures Medical Metabolism Molecular Epidemiology Nested Case-Control Study Nutritional Participant Pattern Persons Physical activity Phytochemical Phytoestrogens Play Population Preventive Primary Prevention Protocols documentation Quality Control Registries Risk Role Sampling Site Smoking Societies Source Soy Foods Specimen Stomach Surveys Tea Update Urine Visit Vital Statistics Vital Status absorption cancer diagnosis cancer risk cohort epidemiology study follow-up in vivo insight lifestyle factors male health malignant stomach neoplasm member men mortality neoplasm registry population based saturated fat urinary

项目摘要

DESCRIPTION (provided by applicant): While it has long been recognized that dietary factors play an important role in the etiology of cancer, information regarding the preventive potential of specific dietary compounds is scarce. The Shanghai Men's Health Study (SMHS) is a population-based cohort study of 61,582 Chinese men between 40 and 74 who lived in urban Shanghai at enrollment. Because intake levels of many suspected cancer-inhibitory dietary factors are high and diverse in Shanghai, the SMHS offers unique opportunities to fill such knowledge gaps. Detailed information on dietary and other lifestyle factors was collected at baseline and is being updated in a follow-up survey. Biological samples were collected from 89% of cohort members. The cohort has been followed for cancer occurrence and deaths via linkage with the population-based Shanghai Cancer Registry and the Shanghai Vital Statistics Unit, as well as through visits to all living cohort members every 2 years. We propose in this renewal application to extend the follow-up of this cohort for 5 more years and to evaluate dietary hypotheses for the lung, stomach, and colorectal (CRC). The primary focus of the study is to determine whether regular tea consumption and high intake of folate, soy foods, allium vegetables, and crucifers are associated with a reduced risk of cancer. We also propose to conduct a nested case-control study to evaluate whether the levels of blood folate, urinary phytoestrogens (CRC only) and isothiocyanate are inversely associated with the risk of cancers of colorectum, lung, and stomach. These biomarkers are aggregate measures of level of intake, absorption, and metabolism and will provide added insight in elucidating the relationship of dietary factors with cancer risk. Blood level C-reactive protein and H.pylori antibodies will also be evaluated in the nested case-control study for CRC and stomach cancer. Finally, we propose to re-survey all living cohort-members to update information on usual dietary intake and other lifestyle factors to refine exposure assessments and to characterize and evaluate how temporal changes in exposures may influence cancer risk. Because of its size, setting, and unique exposure patterns and biological specimens, the SMHS provides an exceptional opportunity to address dietary hypotheses for cancer that cannot be adequately investigated in any other existing cohort study. The results from this study may guide new strategies in the primary prevention of common cancers in both Western and Asian men.

描述（由申请人提供）：虽然人们早已认识到饮食因素在癌症病因学中发挥着重要作用，但有关特定饮食化合物的预防潜力的信息却很少。上海男性健康研究 (SMHS) 是一项以人群为基础的队列研究，纳入了 61,582 名 40 至 74 岁的中国男性，他们入组时居住在上海市区。由于上海许多疑似抗癌饮食因素的摄入量较高且多样化，SMHS 为填补此类知识空白提供了独特的机会。有关饮食和其他生活方式因素的详细信息是在基线时收集的，并在后续调查中进行更新。生物样本是从 89% 的队列成员中采集的。通过与以人群为基础的上海市癌症登记处和上海市人口统计中心的联系，以及每两年对所有活着的队列成员进行访问，对队列的癌症发生和死亡进行跟踪。我们在此更新申请中建议将该队列的随访时间再延长 5 年，并评估肺、胃和结直肠 (CRC) 的饮食假设。该研究的主要重点是确定经常喝茶和大量摄入叶酸、大豆食品、葱类蔬菜和十字花科植物是否与降低癌症风险有关。我们还建议进行一项巢式病例对照研究，以评估血液叶酸、尿液植物雌激素（仅限CRC）和异硫氰酸盐的水平是否与结直肠癌、肺癌和胃癌的风险呈负相关。这些生物标志物是摄入、吸收和代谢水平的综合衡量标准，将为阐明饮食因素与癌症风险的关系提供更多见解。 C反应蛋白和幽门螺杆菌抗体的血液水平也将在结直肠癌和胃癌的巢式病例对照研究中进行评估。最后，我们建议重新调查所有活着的队列成员，以更新有关日常饮食摄入量和其他生活方式因素的信息，以完善暴露评估，并描述和评估暴露的时间变化如何影响癌症风险。由于其规模、环境以及独特的暴露模式和生物样本，SMHS 提供了一个绝佳的机会来解决癌症的饮食假设，而这些假设在任何其他现有的队列研究中都无法得到充分研究。这项研究的结果可能会指导西方和亚洲男性常见癌症一级预防的新策略。