Cellular Networks in Cancer Program

癌症计划中的蜂窝网络

基本信息

批准号：
10693205
负责人：
MELANIE H. COBB
金额：
$ 2.7万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10693205
关键词：
Abnormal Cell Acceleration Basic Science Bioenergetics Biological Markers Cancer Center Support Grant Catchment Area Cell Death Signaling Process Cells Cellular biology Clinic Clinical Clinical Oncology Collaborations Complement Comprehensive Cancer Center DNA Sequence Alteration Data Development Disease Disease Progression Doctor of Philosophy Environment Evolution Faculty Fostering Funding Gene Expression Regulation Genetic Goals Growth Guidelines Homeostasis Human Immunobiology Infrastructure Intervention Intervention Studies Journals Knowledge Malignant - descriptor Malignant Neoplasms Malignant neoplasm of lung Medical Medical center Mentors Metabolism Molecular Neoplasm Metastasis Non-Malignant Patients Peer Review Physicians Physiology Population Population Research Positioning Attribute Prevention strategy Primary Neoplasm Process Productivity Publications Renal carcinoma Research Research Personnel Resistance Resource Sharing Role Science Scientist Signal Transduction Solid Specimen Structure Therapeutic Intervention Tissues Translating Translations Tumor Cell Biology Vision Work cancer initiation cancer prevention cancer therapy cell behavior collaborative environment design diagnostic technologies epigenetic regulation fundamental research insight inter-institutional live cell imaging member mortality neoplastic cell novel strategies prevent programs success translational potential treatment strategy tumor tumor microenvironment tumor progression tumorigenesis

项目摘要

The Cellular Networks in Cancer (CNC) Program is a scientifically rich, collaborative, and productive research program co-led by Melanie Cobb, PhD, and Ralph DeBerardinis, MD, PhD. The vision of the CNC Program is to advance the fundamental knowledge of both intercellular and intracellular networks that contribute to cancer initiation, tumorigenesis, and metastasis, then to translate these findings into novel approaches to cancer prevention and therapy. CNC’s overarching scientific goal is to promote discoveries in how perturbation in these cellular networks contribute to altered tissue physiology and promote cancer. The CNC Program provides a highly interactive research environment that capitalizes on the UT Southwestern Medical Center’s (UTSW) longstanding tradition of basic science discoveries and fosters translation of these discoveries into the development of new biomarkers, diagnostic technologies, and therapeutic interventions in clinical oncology- especially malignancies relevant to the SCCC catchment area (e.g., cancer of the lung and kidney). The program’s structure is purposefully designed to stimulate interdisciplinary intra- and interprogrammatic collaborations with the objective of delivering transformative discoveries. To accomplish this, the Co-Leaders established four vibrant and synergistic subprograms that deliberately align with the strengths of program members and specifically relate to states of perturbed tissue homeostasis in cancer: (1) Signaling and Cell Biology, (2) Epigenetics and Gene Regulation, (3) Immunobiology, and (4) Metabolism. Each subprogram is directed by an investigator who is highly respected for his or her science, mentoring, and collaborative spirit. The subprogram structure and activities have directly contributed to exciting new collaborative projects such as the SPORE in Kidney Cancer. The CNC Program is composed of 59 basic, computational, and physician-scientists from 19 departments and centers at UT Southwestern Medical Center. Seven members of the CNC are Howard Hughes Medical Institute investigators. Annual direct peer-reviewed funding to the CNC Program was $19.3M in 2019. This represents an increase of $3.8M as compared with 2014 data, which were adjusted to conform to revised NCI guidelines. NCI funding has likewise increased from $3M in 2014 to $3.9M in 2019. Program members have authored 750 publications since 2014: 14% represent intraprogrammatic work, 34% are interprogrammatic collaborations, 32% are inter-institutional, and 37% are in journals with an impact factor ≥ 10. CNC Program members are heavily reliant upon all six CCSG Shared Resources—especially Live Cell Imaging and Tissue Management—in furtherance of their scientific goals. The CNC Program’s success is supported by SCCC’s strong infrastructure and grounded in the program’s solid interactions among CNC members and the subprograms, as well as with other SCCC Research Program members and external collaborators.

癌症细胞网络 (CNC) 计划是一项科学性丰富、协作性强且富有成果的研究该项目由 Melanie Cobb 博士和 Ralph DeBerardinis 医学博士共同领导 CNC 项目的愿景是。增进对导致癌症的细胞间和细胞内网络的基础知识起始、肿瘤发生和转移，然后将这些发现转化为治疗癌症的新方法 CNC 的首要科学目标是促进这些扰动的发现。细胞网络有助于改变组织生理学并促进癌症。利用 UT 西南医学中心 (UTSW) 的高度互动的研究环境基础科学发现的悠久传统，并促进将这些发现转化为临床肿瘤学中新生物标志物、诊断技术和治疗干预措施的开发- 尤其是与 SCCC 流域相关的恶性肿瘤（例如肺癌和肾癌）。计划的结构是有目的地设计的，以刺激跨学科的计划内和计划间的合作为了实现这一目标，联合领导人共同致力于实现变革性的发现。建立了四个充满活力和协同作用的子计划，与计划的优势紧密结合成员，特别与癌症中组织稳态紊乱的状态相关：(1) 信号传导和细胞生物学，(2) 表观遗传学和基因调控，(3) 免疫生物学，以及 (4) 代谢每个子程序都是。由一位因其科学、指导和协作精神而受到高度尊重的研究者指导。次级方案结构和活动直接促进了令人兴奋的新合作项目，例如肾癌中的 SPORE 项目由 59 名基础科学家、计算科学家和医师科学家组成。霍华德是来自 UT 西南医学中心 19 个科室和中心的 CNC 成员。休斯医学研究所研究人员每年为 CNC 项目提供的直接同行评审资金为 1930 万美元。 2019 年。这比 2014 年的数据增加了 380 万美元，该数据经过调整以符合修订后的 NCI 指南。 NCI 资金同样从 2014 年的 300 万美元增加到 2019 年的 390 万美元。自 2014 年以来，成员已撰写了 750 篇出版物：14% 代表计划内工作，34% 代表项目间合作，32%是机构间合作，37%是在影响因子≥10的期刊上。 CNC 计划成员严重依赖所有六个 CCSG 共享资源，尤其是活细胞成像和组织管理——为了促进其科学目标，CNC 计划的成功得到了支持。 SCCC 拥有强大的基础设施，并以 CNC 成员与该计划之间的牢固互动为基础子计划，以及其他 SCCC 研究计划成员和外部合作者。