Prosthetic System for Distributed Neuronal Recording

用于分布式神经元记录的假体系统

• 批准号: 7771753
• 负责人: Charles M Gray
• 金额: $ 30.64万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2012-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7771753
• 关键词: Animals; Behavior; Brain; Brain imaging; Brain region; Caring; Cephalic; Cerebral hemisphere; Cerebrovascular Circulation; Communities; Computers; Data; Devices; Dimensions; Distributed Systems; Dura Mater; Electrodes; Functional Imaging; Functional Magnetic Resonance Imaging; Generic Drugs; Goals; Gray unit of radiation dose; Implant; Implanted Electrodes; Infection; Location; Macaca; Macaca mulatta; Magnetism; Marshal; Mechanics; Microelectrodes; Modeling; Monitor; Monkeys; Neurons; Operative Surgical Procedures; Performance; Physiological; Population; Process; Prosthesis; Research; Research Personnel; Resolution; Sampling; Site; Structure; Surface; System; Testing; Time; Tube; awake; base; brain tissue; cognitive function; cost; cranium; density; design; implantation; instrumentation; new technology; nonhuman primate; programs; relating to nervous system; spatiotemporal; stem; theories; wound

DESCRIPTION (provided by applicant): The goal of the proposed research is to advance our understanding of higher brain functions by developing a new class of instrumentation that will enable investigators to simultaneously monitor neuronal activity from tens to hundreds of independently movable microelectrodes that are semi-chronically implanted in widespread regions of the brains of awake, behaving monkeys. To accomplish this objective, we plan to design and build an integrated system, consisting of a form-fitting chamber and a modular, replaceable guide array and microdrive, for implanting and independently manipulating up to 240 microelectrodes in the brains of alert macaque monkeys. The system will provide high density electrophysiological access to an entire cerebral hemisphere and enable simultaneous recording of unit and local field potential activity from many cortical and/or subcortical locations for periods lasting many weeks or months. We will implant and test the system in three macaque monkeys in order to i) optimize the design of the system and minimize the time and expense required for its manufacture, ii) determine the most effective design of the system to facilitate its surgical implantation, insure its mechanical stability, reduce the chances of intracranial infection, and provide for the best possible care of the wound margins surrounding the implant, iii) evaluate the long-term quality and stability of the electrophysiological recordings, and iv) evaluate the effects of the implanted electrodes and guide tubes on the histological structure of the brain tissue. This approach will insure that the system is both generic and modular in its design while optimizing its capabilities and minimizing the costs for its manufacture. When completed, the proposed system will provide the research community with a new technology for long-term monitoring of neuronal activity from distributed locations in the brain of non-human primates. This technological advance will open up vast new opportunities for studying the neural basis of higher brain functions.

描述（由申请人提供）：拟议的研究的目的是通过开发新的仪器来提高我们对较高大脑功能的理解，这将使研究人员能够同时监视神经元活动从数十到数百个独立的可移动的微电极长期植入清醒大脑的广泛地区，表现出猴子。为了实现这一目标，我们计划设计和构建一个集成系统，该系统由一个拟合室和一个模块化的，可更换的指南阵列和微型设备组成，以植入和独立地操纵多达240个微电极在警报猕猴的警报中。该系统将为整个脑半球提供高密度的电生理通道，并能够同时记录来自许多皮质和/或皮层下位置的单位和局部野外活性，持续了数周或几个月。我们将植入并测试系统中的三杏仁猴，以便i）优化系统的设计并最大程度地减少其制造所需的时间和费用，ii）确定系统的最有效设计，以促进其手术植入，确保其保险，它的机械稳定性，减少颅内感染的机会，并为植入物周围的伤口边缘提供最佳护理，iii）评估电生理记录的长期质量和稳定性，iv）评估植入的效果）电极和指导管关于脑组织的组织学结构。这种方法将确保该系统在设计中既通用又是模块化的，同时优化其功能并最大程度地减少其制造成本。完成后，拟议的系统将为研究社区提供一种新技术，以长期监测非人类灵长类动物大脑中分布式位置的神经元活动。这一技术进步将为研究较高大脑功能的神经基础提供巨大的新机会。