Internal and external influences on infants' short-term feeding behaviors

对婴儿短期喂养行为的内部和外部影响

基本信息

批准号：
7913990
负责人：
Alison K. Ventura
金额：
$ 4.76万
依托单位：
MONELL CHEMICAL SENSES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-01 至 2012-05-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The objective of this research program is to test hypotheses related to understanding whether and how the composition of formulas fed, and the feeding practices mothers use, influence young infants' short-term feeding behaviors. The proposed research aims to elucidate potential strategies for optimizing feeding during infancy, which is a first step toward primary prevention of the negative health outcomes associated with undesirable intake and weight gain patterns, such as obesity and type II diabetes. The proposed research builds upon prior research from our laboratory demonstrating that when infants feed protein hydrolysate formula (PHF), which is higher in certain amino acids such as free glutamate, they consume less formula than when feeding cow-milk formulas (CMF), despite showing similar levels of satiation. The primary aim of this research is to test the hypothesis that infants will become satiated faster and will stay satiated longer when feeding formula with higher free glutamate compared to formula with lower free glutamate during infant-led feeding conditions. Feeding during infancy is unique to any other developmental period because infants are entirely dependent on caregivers for what and when they feed; study of infants in isolation of their caregivers creates an incomplete understanding of feeding during infancy. Thus, a secondary aim of this research is to test the hypothesis that, during typical bottle-feeding conditions, the feeding practices of some mothers will override the satiating properties of formulas with high levels of free glutamate. We propose a within-subject design to test our hypotheses. To test our primary hypothesis, we will assess infant consumption during a feed (satiation), latency until a subsequent feed (satiety), and changes in temperature, activity and sleep, in response to feeding PHF, CMF or CMF with added glutamate (CMF+glu) during infant-led feeding conditions, where the infant determines the timing, pace, and duration of the feed. To test our secondary hypothesis, we will assess infant intake and feeding behaviors in response to CMF, PHF and CMF+glu during typical bottle-feeding conditions, in which the mother decides the timing, pace, and duration of the feed. We will then compare feeding during this condition with feeding during the infant-led conditions. Test formulas and feeding conditions will be randomized and counterbalanced across six days of testing. PUBLIC HEALTH RELEVANCE: we know little about influences on and mechanisms underlying infants' developing feeding behaviors. The proposed research will provide important new insights into the role of both internal and external influences on feeding during a developmental period when appropriate intake patterns are especially important for the promotion of optimal growth and development.

描述（由申请人提供）：该研究计划的目的是测试与了解饲料的公式的成分以及如何影响母亲使用的喂养实践有关的假设，会影响年轻婴儿的短期喂养行为。拟议的研究旨在阐明在婴儿期优化喂养的潜在策略，这是朝着对与不良摄入量和体重增加模式相关的负面健康结果（例如肥胖和II型糖尿病）产生的负面健康结果的第一步。拟议的研究基于我们实验室的先前研究，表明，当婴儿喂养蛋白质水解物配方奶粉（PHF）时，在某些氨基酸（例如游离谷氨酸）中，它们的消耗量要比喂养牛乳式（CMF）时消耗的配方少，尽管表现出相似的饱满水平。这项研究的主要目的是检验以下假设：与在婴儿主导的喂养条件下，婴儿喂养配方较高时，以较高的自由谷氨酸喂食的喂养配方时会保持更快的状态，并保持更长的饱腹感。婴儿期间的喂养是任何其他发育时期独有的，因为婴儿完全取决于护理人员的喂养和何时喂养。对婴儿隔离的婴儿的研究产生了对婴儿期间喂养的不完全理解。因此，这项研究的次要目的是检验以下假设：在典型的奶瓶喂养条件下，一些母亲的喂养实践将覆盖高水平的游离谷氨酸的公式的满足特性。我们提出了一个受试者内部设计以检验我们的假设。为了检验我们的主要假设，我们将评估婴儿在饲料（饱满），潜伏期，直到随后的饲料（饱腹感）以及温度，活动和睡眠的变化，以响应于喂养PHF，CMF，CMF或CMF，添加谷氨酸（CMF+GLU）在婴儿供养条件下，在婴儿喂养条件下，婴儿在婴儿期间，在婴儿喂养条件下确定了时间，请定时，喂养时间，并确定时间，喂养时间和终点。为了检验我们的次要假设，我们将在典型的奶瓶喂养条件下评估婴儿的摄入量和喂养行为，响应CMF，PHF和CMF+GLU，母亲决定饲料的时间，节奏和持续时间。然后，我们将在这种情况下将喂养与婴儿为主导的条件期间的喂养进行比较。在六天的测试中，测试配方和喂养条件将被随机和平衡。公共卫生相关性：我们对婴儿发展行为的影响和机制的影响和机制知之甚少。拟议的研究将为内部和外部影响在发育时期的饲料作用时提供重要的新见解，而适当的摄入模式对于促进最佳增长和发展尤为重要。