Long Term Interfacing and Signaling of Neuronal Tissue Using Cubic Silicon Carbid

使用立方碳化硅的神经元组织的长期连接和信号传导

• 批准号: 8061410
• 负责人: Christopher Leroy Frewin
• 金额: $ 5.03万
• 依托单位: UNIVERSITY OF SOUTH FLORIDA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8061410
• 关键词: Acute; Address; Amyotrophic Lateral Sclerosis; Biocompatible; Cellular biology; Central Nervous System Diseases; Chemicals; Chronic; Communication; Construction Materials; Detection; Development; Devices; Diamond; Discipline; Disease; Elasticity; Electrodes; Engineering; Equipment Malfunction; Evaluation; Figs - dietary; Goals; Hippocampus (Brain); Immune response; Injury; Journals; Knowledge; Laboratory Animals; Lead; Learning; Life; Limb Prosthesis; Measurement; Measures; Medical; Medicine; Molecular Biology; Neuraxis; Neurons; Neurosciences; Physics; Property; Prosthesis; Reaction; Research; Research Proposals; Science; Semiconductors; Series; Signal Transduction; Silicon; Slice; Stroke; System; Systems Integration; Techniques; Technology; Time; Tissues; Trauma; Work; Writing; biomaterial compatibility; brain machine interface; college; design; electrical property; functional gain; improved; in vivo; meetings; nervous system disorder; neurophysiology; novel; protocol development; public health relevance; silicon carbide; skills; success; symposium

DESCRIPTION (provided by applicant): Current brain machine interface (BMI) systems have shown success in providing relief for some central nervous system (CNS) disorders caused by disease or trauma. Unfortunately, widespread utility has been hampered by challenges associated with the configuration of non-invasive external receivers intended to detect in vivo electrical signals. The alternative is an implantable neuronal prosthetic capable of CNS integration allowing direct detection and bi-directional signaling. Unfortunately, these devices elicit chronic immune responses mainly due to their materials of construction which directly lead to decreased functionality and device failure. We have developed a novel material, cubic silicon carbide (3C-SiC), that meets all the requirements of an implantable neuronal prosthetic device and addresses the major problems of biocompatibility and passive electric properties. The specific aims of the application have been designed to rigorously evaluate the biocompatibility of this and other semi-conductor materials in vivo longitudinally, determine the ability of a neuronal activation device constructed of 3C-SiC to elicit excitation and plasticity of organotypic hippocampal slice cultures and generate an implantable electrode device capable of bi-directional communication in vivo. In conjunction with the experimental aims, the applicant will advance his interdisciplinary knowledge, concentrating on disciplines applicable with relating technology to neuroscience, and further develop scientific writing and presentation skills. PUBLIC HEALTH RELEVANCE: This application proposes to study the interaction between the central nervous system and a novel neuronal prosthetic developed by the applicant. This novel device has the potential to improve the lives of people suffering from many neurological disorders, such as amyotrophic lateral sclerosis (ALS), trauma resultant from stroke or acute injury, or be to used as an interface to control mechanized artificial limbs.

描述（由申请人提供）：当前的脑机界面（BMI）系统在为某些由疾病或创伤引起的中枢神经系统（CNS）疾病提供救济方面已成功。不幸的是，与旨在在体内电信号中检测的非侵入性外部接收器相关的挑战所妨碍了广泛的效用。另一种选择是一种可植入的神经元假体，能够进行CNS整合，允许直接检测和双向信号传导。不幸的是，这些设备主要是由于其构造材料直接导致功能和设备故障的降低，引起了慢性免疫反应。我们开发了一种新型的材料，即立方硅（3C-SIC），该材料满足了可植入的神经元假体设备的所有要求，并解决了生物相容性和被动电特性的主要问题。该应用程序的具体目的已被设计为严格评估体内和其他半导体材料在纵向上的生物相容性，确定由3C-SIC构建的神经元激活装置的能力，以引起3C-SIC引起的激发和可塑性，并使塑性构造的可塑性性和可塑性。生成能够在体内双向通信的植入电极设备。结合实验目的，申请人将促进其跨学科知识，专注于适用于技术与神经科学有关的学科，并进一步发展科学的写作和演示技巧。 公共卫生相关性：本申请建议研究中枢神经系统与申请人开发的新型神经元假体之间的相互作用。这种新型装置有可能改善患有许多神经系统疾病的人的生活，例如肌萎缩性侧索硬化症（ALS），卒中或急性损伤导致的创伤，或者被用作控制机械化的人工四肢的界面。