A Follow-up Study for Causes of Cancer in Black Women

黑人女性癌症病因的后续研究

基本信息

批准号：
10701009
负责人：
Kimberly A Bertrand
金额：
$ 204.28万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-21 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10701009
关键词：
Address Affect Age Alzheimer&apos s Disease Archives Behavior Behavioral Biological Assay Biological Markers Biological Specimen Banks Blood Blood specimen Breast COVID-19 Cancer Etiology Cancer Survivor Cancer Survivorship Cardiovascular Diseases Cessation of life Characteristics Collection Colon Carcinoma Colonic Polyps Colorectal Colorectal Cancer DNA DNA Repository Data Data Collection Data Files Diagnosis Disease Disparity End stage renal failure Endometrial Enrollment Environmental Exposure Environmental Risk Factor Ethnic Population Follow-Up Studies Frequencies Funding Future Genetic Goals Health Health Status Hypertension Impaired cognition Incidence Individual Infertility Infrastructure Knowledge Length Leukocytes Link Liver Lung Lupus Maintenance Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of ovary Malignant neoplasm of pancreas Mammary Neoplasms Mammography Medical Medical Records Medicare Mentors Methodology Methods Minority Groups Modernization Molecular Epidemiology of Cancer Multiple Myeloma Neighborhoods Newly Diagnosed Newly Diagnosed Disease Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Ovarian Pancreas Paper Participant Peer Review Pharmaceutical Preparations Plasma Premature Birth Preparation Prospective, cohort study Psychosocial Factor Publications Quality of life Questionnaires RNA Recurrence Renal carcinoma Reporting Research Research Design Research Personnel Risk Risk Factors Risk Reduction SARS-CoV-2 infection Saliva Sampling Sarcoidosis Serum Sleep Disorders Source Specimen Structural Racism System Time Tissue Banks Tissue Microarray Tissue Sample Training Tumor Tissue Underrepresented Minority Update Uterine Fibroids Vulnerable Populations Woman Women&apos s Health black women cancer diagnosis cancer health disparity cancer risk cancer survival cohort cost data sharing follow-up genetic risk factor health disparity health inequalities indexing interest malignant breast neoplasm microbial minority investigator mortality neoplasm registry novel observational cohort study patient engagement racial disparity racial health disparity racial population repository research study response saliva sample social tumor virtual web site

项目摘要

Pervasive health disparities affecting U.S. Black women are now widely recognized, but large gaps in knowledge remain. We began the Black Women’s Health Study (BWHS) in 1995 to identify reasons for disparities, including cancer health disparities; at that time Black women represented a very small proportion of participants in observational cohort studies. We enrolled 59,000 participants over an 8-month period in 1995 via a lengthy mail questionnaire. Subsequently, participants were asked to complete follow-up questionnaires, usually four pages in length, every two years, either on paper or online. In the most recent questionnaire cycle, responses were split equally between the two methods. Over 51,000 participants are still alive and response rates continue to be good. Among approximately 48,000 who were sent a 2019/20 questionnaire, 71% completed it and 79% responded to either that questionnaire or the prior one. Saliva samples as a source of germline and microbial DNA have been obtained and stored for 27,800 participants and blood samples for 13,030 participants. Breast tumor samples have been obtained for over 1,000 breast cancer cases; tumor tissue collection was begun in the most recent funding period for four other cancers. BWHS research covers the spectrum from individual behaviors, medication use, and other characteristics, to psychosocial factors, genetic factors, and neighborhood-level factors. Peer-reviewed publications have addressed a range of health conditions: cancers that include breast, lung, ovarian, colorectal, endometrial, pancreatic, liver, and multiple myeloma; type 2 diabetes; obesity; lupus; sarcoidosis; preterm birth; infertility; uterine leiomyoma; cognitive decline; sleep disorders; hypertension; COVID-19 infection; and mortality. More than half of current participants are under age 64, affording the potential for additional research on cancer etiology, including with collection of new or repeated exposures and covariates. During the next funding period, we expect to produce impactful findings with regard to risk of multiple myeloma and colorectal, lung, and pancreatic cancer; breast and colorectal cancer survivorship; cognitive decline and Alzheimer’s disease; end-stage renal disease; and other conditions, such as COVID-19, that disproportionately affect Black women. (According to the National Death Index (NDI), over 100 BWHS participants died from COVID-19 infection in 2020.) To reduce costs, we will reduce the frequency of questionnaires while still linking to NDI, Medicare, and cancer registries to identify and confirm new cancers, other illnesses, and deaths. We will continue to share BWHS data and samples with outside investigators, and underrepresented minority investigators in particular, and will modernize our website and data sharing systems to increase accessibility. Continued follow-up of this landmark study is critical to inform opportunities for risk reduction in a vulnerable population and to close the gap in racial disparities in cancer and other illnesses.

影响美国黑人女性的普遍健康差异现已得到广泛认可，但在健康方面存在巨大差距我们于 1995 年开始开展黑人女性健康研究 (BWHS)，以找出原因。差异，包括癌症健康差异；当时黑人女性只占很小的比例； 1995 年的 8 个月期间，我们招募了 59,000 名参与者。随后，参与者被要求完成后续调查问卷，通常为四页，每两年一次，无论是纸质的还是在线的。两种方法的反应均等超过 51,000 名参与者仍然活着并且有反应。在收到 2019/20 年调查问卷的约 48,000 名受访者中，有 71% 的受访者的满意度仍然良好。完成了该调查，79% 的人回答了该调查问卷或之前的唾液样本作为唾液样本的来源。已获取并储存了 27,800 名参与者的种系和微生物 DNA 以及血液样本已获得 1,000 多个乳腺癌病例的 13,030 名参与者的乳腺肿瘤样本； BWHS 研究涵盖的其他四种癌症的组织收集工作是在最近的资助期间开始的。从个人行为、药物使用和其他特征到社会心理因素的范围，遗传因素和社区层面的因素已经解决了一系列的健康问题。病症：癌症，包括乳腺癌、肺癌、卵巢癌、结直肠癌、子宫内膜癌、胰腺癌、肝癌和多种癌症骨髓瘤; 2型糖尿病; 结节病; 下降；睡眠障碍；COVID-19 感染和死亡率；年龄在 64 岁以下，提供了对癌症病因学进行更多研究的潜力，包括收集在下一个资助期间，我们预计会产生有影响力的新的或重复的暴露和协变量。关于多发性骨髓瘤、结直肠癌、肺癌和胰腺癌风险的研究结果；结直肠癌存活率；认知能力下降和阿尔茨海默病； COVID-19 等疾病对黑人女性的影响尤为严重。指数 (NDI)，2020 年有超过 100 名 BWHS 参与者死于 COVID-19 感染。）为了降低成本，我们将减少调查问卷的频率，同时仍与 NDI、医疗保险和癌症登记处联系起来，以识别和确认新的癌症、其他疾病和死亡，我们将继续与 BWHS 共享数据和样本。外部调查员，特别是代表性不足的少数族裔调查员，并将使我们的网站现代化和数据共享系统以提高可访问性，对这项具有里程碑意义的研究的持续跟进至关重要。为弱势群体提供减少风险的机会，并缩小种族差异癌症和其他疾病。

项目成果

期刊论文数量（20）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effect of Culturally Tailored, Internet-Delivered Cognitive Behavioral Therapy for Insomnia in Black Women: A Randomized Clinical Trial.

文化定制、互联网提供的认知行为疗法对黑人女性失眠的影响：一项随机临床试验。

DOI：
发表时间：
2022-06-01
期刊：
影响因子：
25.8
作者：
Zhou, Eric S;Ritterband, Lee M;Bethea, Traci N;Robles, Yvonne P;Heeren, Timothy C;Rosenberg, Lynn
通讯作者：
Rosenberg, Lynn

Vitamin D and risk of hypertension among Black women.

黑人女性的维生素 D 和高血压风险。

DOI：
发表时间：
2023-02
期刊：
影响因子：
0
作者：
Sheehy, Shanshan;Palmer, Julie R;Cozier, Yvette;Bertrand, Kimberly A;Rosenberg, Lynn
通讯作者：
Rosenberg, Lynn

Sarcoidosis epidemiology: recent estimates of incidence, prevalence and risk factors.

结节病流行病学：发病率、患病率和危险因素的最新估计。

DOI：
发表时间：
2020
期刊：
影响因子：
3.3
作者：
Arkema, Elizabeth V;Cozier, Yvette C
通讯作者：
Cozier, Yvette C

Hair relaxer use and risk of uterine cancer in the Black Women's Health Study.

黑人女性健康研究中头发松弛剂的使用和子宫癌的风险。

DOI：
发表时间：
2023-12-15
期刊：
影响因子：
8.3
作者：
Bertrand, Kimberly A;Delp, Lauren;Coogan, Patricia F;Cozier, Yvette C;Lenzy, Yolanda M;Rosenberg, Lynn;Palmer, Julie R
通讯作者：
Palmer, Julie R

Can Breast Cancer Prevention Strategies Be Tailored to Biologic Subtype and Unique Reproductive Windows?

乳腺癌预防策略可以根据生物亚型和独特的生殖窗口量身定制吗？