fMRI During Simulated Social Interactions in Schizophrenia: Emotion and Cognition

精神分裂症模拟社交互动期间的功能磁共振成像：情绪和认知

• 批准号: 7891276
• 负责人: BRUCE E. WEXLER
• 金额: $ 35.38万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-15 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7891276
• 关键词: Affect; Affective; Amygdaloid structure; Basal Ganglia; Behavior; Behavioral; Brain; Brain Mapping; Brain imaging; Cerebral Dominance; Childhood; Cocaine; Cognition; Cognitive; Cognitive deficits; Competence; Complex; Diagnosis; Disease; Emotional; Emotions; Exposure to; Face; Failure; Family member; Functional Magnetic Resonance Imaging; Gambling; Goals; Imaging Techniques; Impaired cognition; Investigation; Knowledge; Measures; Medial; Methodology; Methods; Neurobiology; Neurosciences Research; Outpatients; Patients; Perception; Performance; Persons; Prefrontal Cortex; Process; Quality of life; Research; Schizophrenia; Short-Term Memory; Simulate; Social Behavior; Social Interaction; Symptoms; Videotape; Voice; Work; affective neuroscience; base; cocaine use; cognitive neuroscience; deficit syndrome; experience; fusiform face area; innovation; neuropathology; positive emotional state; psychologic; relating to nervous system; social; social cognition; social neuroscience; social skills; therapy development; tool

DESCRIPTION (provided by applicant): Social interactions are abnormal in many people with schizophrenia even during childhood before their illnesses are manifest and diagnosed. Limitations in social connectedness discomfort in social interactions poorly developed social skills, blunted and/or socially inappropriate emotion, and emotion- related disturbances of cognition are all features of schizophrenia once manifest and diagnosed. Despite the recognized importance of this complex of social, affective and cognitive disturbances, the associated neurobiological abnormalities have been little studied and are poorly understood. We have developed a new paradigm for studying regional brain activations with fMRI during simulated emotion-evoking social interactions. We created video tapes of actors talking directly to the subjects about happy or sad past personal experiences, and displaying the full range of facial, voice and body manifestations of the emotion. This multidimensional, dynamic and socially contextualized stimulation has greater real world validity than the sequential presentation of still photographs of people's faces typically used in brain imaging studies of social-emotional activation. By comparing brain activations in healthy subjects during these tapes to activations when the actors talked about emotionally-neutral experiences, we identified regional brain activations common to both socially generated emotions and activations specific to each emotion. We also created tapes in which actors pretended to use cocaine or prepare to gamble and asked the subjects to join them as they did. With these and the original tapes we identified brain activation abnormalities in cocaine addicts and pathological gamblers related to their primary pathological behaviors and to emotion-evoking social interactions. The studies proposed in this application would be the first to apply this method to the study of schizophrenia. In earlier work, we demonstrated that cognition and brain laterality were abnormally affected by negative emotion in people with schizophrenia. To investigate this further, we incorporated a working memory task within the video tapes of simulated emotion-evoking social interactions. In preliminary studies of healthy subjects we have demonstrated that happy emotion leads to enhanced cognition-related activation of basal ganglia-thalamocortical circuits. We also propose to use this new methodology to study the effects of socially generated emotion on cognition related brain activation in people with schizophrenia. We predict that positive emotion-evoking social interactions will not enhance cognition-related brain activity in people with schizophrenia as it does in healthy people. Many people with schizophrenia have problems with the expression and understanding of emotion essential in social interactions. These problems precede the diagnosis of illness, are present to some degree in family members, limit patient quality of life and even the ability to participate in treatments. In this project we will use new knowledge from social neuroscience research and newly developed brain imaging procedures to study brain aspects of the patient problems in social-emotional function.

描述（由申请人提供）：许多精神分裂症患者的社交互动是异常的，即使在童年时期，他们的疾病也被诊断出来。社交联系不适的局限性社交互动不适，社交技能不佳，钝性和/或社会不适当的情绪以及与情绪相关的认知障碍都是精神分裂症的特征，曾经表现出来。尽管这种社会，情感和认知障碍的复杂性具有公认的重要性，但相关的神经生物学异常几乎没有研究，也没有理解。我们开发了一种新的范式，用于在模拟情绪引起的社交互动期间使用fMRI研究区域大脑激活。我们创建了直接与主题交谈的演员录像带，以了解幸福或悲伤的过去个人经历，并展示情感的全部面部，声音和身体表现。这种多维，动态和社会上下文化的刺激具有更大的现实世界有效性，而不是在社会情感激活的大脑成像研究中使用的静止照片的顺序呈现。通过将这些录音带中健康受试者的大脑激活与演员谈论情绪中性体验时的激活进行比较，我们确定了社会产生的情绪和每种情绪所特有的激活共同的区域大脑激活。我们还创建了录音带，其中演员们假装使用可卡因或准备赌博，并要求受试者像他们一样加入他们。通过这些和原始磁带，我们确定了可卡因成瘾者和病理赌徒与其主要病理行为以及情绪引起的社交互动有关的大脑激活异常。在本应用中提出的研究将是第一个将此方法应用于精神分裂症研究的研究。在较早的工作中，我们证明了精神分裂症患者的负面情绪的认知和大脑横向性异常受到影响。为了进一步研究，我们将工作记忆任务纳入了模拟情绪引起的社交互动的录像带中。在对健康受试者的初步研究中，我们已经证明，快乐的情绪会导致与认知相关的基础神经节 - 丘脑皮层电路的激活增强。我们还建议使用这种新方法来研究社会产生的情绪对精神分裂症患者认知相关的大脑激活的影响。我们预测，积极的情绪引起的社交互动不会像健康人那样增强精神分裂症患者的认知相关的大脑活动。许多精神分裂症患者对社交互动必不可少的情绪的表达和理解有问题。这些问题先于诊断疾病，在某种程度上出现在家庭成员中，限制患者的生活质量，甚至限制参加治疗的能力。在这个项目中，我们将使用社会神经科学研究和新开发的大脑成像程序中的新知识来研究社会情感功能中患者问题的大脑方面。