Studies of clinical endocrine tumors

内分泌肿瘤的临床研究

基本信息

批准号：
7734161
负责人：
PHILLIP GORDEN
金额：
$ 19.91万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7734161
关键词：
Acromegaly Behavior Benign Clinical Collaborations Diagnostic Endocrine Gland Neoplasms Endocrine Syndrome Endocrinologist Event Genetic Genetic Variation Histologic Human Institutes Localized Molecular Genetics National Institute of Diabetes and Digestive and Kidney Diseases Neuroendocrine Tumors Operative Surgical Procedures Other Resources Pathology Patients Published Comment Radiology Specialty Research Personnel Resources Therapeutic Tissues Variant adenoma insulin secretion malignant endocrine gland neoplasm pancreatic neoplasm response tumor

Acromegaly Behavior Benign Clinical Collaborations Diagnostic Endocrine Gland Neoplasms Endocrine Syndrome Endocrinologist Event Genetic Genetic Variation Histologic Human Institutes Localized Molecular Genetics National Institute of Diabetes and Digestive and Kidney Diseases Neuroendocrine Tumors Operative Surgical Procedures Other Resources Pathology Patients Published Comment Radiology Specialty Research Personnel Resources Therapeutic Tissues Variant adenoma insulin secretion malignant endocrine gland neoplasm pancreatic neoplasm response tumor

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项目摘要

Specific endocrine syndromes are produced in response to benign and malignant tumors of endocrine tissue. We have been part of a collaborative group in the Clinical Center, NCI, and NINDS. We study patients with acromegaly in collaboration with Dr. Edward Oldfield of NINDS. These studies consist of careful phenotypic characterization of the patient followed by surgery to remove the adenoma. This is followed by histologic and molecular genetic characterization so that phenotypic-genotypic characterization can be made. The second group of studies is in collaboration with Dr. Steven Libutti in which a similar group of phenotypic-genotypic characterization is underway. In addition, Clinical Center Radiology is involved in collaboration to localize the pancreatic tumors for surgical localization. These tumors have also been used as a resource by other investigators in NIDDK, by other institutes and by NCI pathology.

特异性内分泌综合征是响应内分泌组织的良性和恶性肿瘤而产生的。我们一直是临床中心，NCI和NINDS的合作小组的一部分。我们与Ninds的爱德华·奥尔德菲尔德（Edward Oldfield）合作研究了肢端肥大症患者。这些研究包括对患者进行仔细的表型表征，然后进行手术以去除腺瘤。其次是组织学和分子遗传特征，以便可以做出表型基因型表征。第二组研究与史蒂文·利布蒂（Steven Libutti）博士合作，其中类似的表型基因型表征正在进行中。此外，临床中心放射学参与了合作，以将胰腺肿瘤定位用于手术定位。这些肿瘤也已被NIDDK，其他研究所和NCI病理学的其他研究人员用作资源。