The Effect of Salsalate on Insulin Action and Secretion

水杨酸对胰岛素作用和分泌的影响

• 批准号: 7734311
• 负责人: Jonathan Krakoff
• 金额: $ 22.4万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7734311
• 关键词: Accounting; Anti-Inflammatory Agents; Anti-inflammatory; Area Under Curve; Chronic; Deterioration; Development; Diabetes Mellitus; Fasting; Glucose; Glucose Plasma Concentration; Gold; Hyperglycemia; IKBKB; Inflammation; Infusion procedures; Insulin; Intervention; Measurement; Measures; Medicine; Non-Insulin-Dependent Diabetes Mellitus; OGTT; Obesity; Pathway interactions; Placebos; Proteins; Rate; Role; Standards of Weights and Measures; Techniques; Week; day; glucose uptake; improved; insulin secretion; monocyte; randomized placebo controlled trial; salicylsalicylic acid; volunteer

This study is a randomized, placebo controlled trial to examine the effects of a short course of salsalate (3 grams per day for 7 days) on insulin action and secretion, using gold standard measurements of insulin action, the euglycemic-hyperinsulinemic clamp, and insulin secretion, the hyperglycemic clamp technique. During this study measures of inflammation are collected prior to and following the intervention to investigate how changes in these markers are associated with changes insulin action. Monocytes are also collected prior and following the intervention to measure NF-B activity to specifically investigate the role of the IKK beta pathway in insulin action. Recruitment was completed in February, 2008. After one week, volunteers who received Salsalate had lower fasting plasma glucose concentrations, lower glucose area under the curve during an oral glucose tolerance test, and lower c-reactive protein concentrations. Glucose infusion rates during the clamp were also higher in those who received Salsalate, but so were steady state insulin concentrations. After accounting for the change in insulin concentration, there was no difference in glucose uptake between the placebo and Salsalate group. Therefore, Salsalate improves glycemia, but via its effect on insulin clearance, not via a direct effect on insulin action. In support of this, Salsalate treatment did not decrease NF-B activity. Results of the effect of Salsalate on insulin secretion are currently pending.

这项研究是一项随机的，安慰剂对照试验，可利用胰岛素作用的黄金标准测量值，尤利科血糖 - 血症纤维蛋白血症夹和胰岛素分泌，高血糖夹具技术的高标准测量，以检查短期萨拉酸盐（每天3克每天3克）对胰岛素作用和分泌的影响。 在这项研究中，在干预之前和之后收集了炎症的措施，以研究这些标记中的变化与胰岛素作用的变化如何相关。在干预措施之后，还收集了单核细胞，以测量NF-B活性，以特别研究IKKβ途径在胰岛素作用中的作用。招聘于2008年2月完成。 一周后，接受萨拉酸酯的志愿者的空腹血浆浓度较低，口服葡萄糖耐受性测试期间曲线下的葡萄糖面积较低，并且C反应性蛋白质浓度较低。在接受沙盐的患者中，夹具期间的葡萄糖输注率也更高，但稳态胰岛素浓度也是如此。考虑到胰岛素浓度的变化后，安慰剂和盐酸组之间的葡萄糖吸收没有差异。因此，盐酸会改善血糖，但通过对胰岛素清除的影响，而不是直接对胰岛素作用的影响。为此，盐酸治疗不会降低NF-B活性。目前正在待审.Salsalate对胰岛素分泌的影响的结果。