Predictors of Reactivity to Physical Activity Measurement among Women in Midlife with Elevated CVD Risk: Examination Across 7 Studies

CVD 风险升高的中年女性体力活动测量反应的预测因素：7 项研究的检查

基本信息

批准号：
10671010
负责人：
Danielle Arigo
金额：
$ 7.5万
依托单位：
ROWAN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10671010
关键词：
Accelerometer Address Adult Affect Age Aging Area Attention Behavior Bias (Epidemiology)Body mass index Characteristics Child Clinical Research Clinical Trials Data Data Set Development Evaluation Goals Hypertension Individual Individual Differences Influentials Institution Intervention Intervention Studies Life Light Exercise Masks Measurement Medical Menopausal Status Mentored Patient-Oriented Research Career Development Award Mentors Modeling Monitor Motivation Obesity Outcome Participant Pattern Physical activity Physical assessment Physiological Population Populations at Risk Procedures Recommendation Research Research Activity Research Design Research Personnel Resources Risk Source Subgroup Techniques Testing Woman Work cardiovascular disorder risk depressive symptoms design epidemiology study exercise intervention innovation insight middle age monitoring device multilevel analysis psychologic public database response risk mitigation sedentary lifestyle sex study characteristics tool vigorous intensity wearable device young adult

项目摘要

Abstract Risks for cardiovascular disease (CVD) substantially increase for women during midlife (ages 40-60). Increasing physical activity (PA) during midlife can mitigate these risks and there is a critical need for research that can reduce barriers to engagement in this population. PA measurement reactivity, or a change in PA engagement in response to the introduction of PA measurement, may bias the objective assessment of PA that is critical to evaluating PA promotion efforts. Specifically, PA measurement reactivity could inflate estimates of PA early in a monitoring period and lead to incorrect conclusions about PA engagement among at-risk groups such as women in midlife. At present, however, evidence supporting PA measurement reactivity as a key confound in PA research is mixed, including preliminary evidence from the PI’s K23 award. The proposed study is designed to address three key limitations of existing work: (1) emphasis on children or healthy, young adults with low risk for CVD, (2) lack of consistency with respect to the definition of reactivity and the PA outcome(s) most likely to be affected (e.g., steps vs. minutes of moderate-to-vigorous activity [MVPA] per day), and (3) lack of attention to the contexts whereby reactivity may be most influential (e.g., study designs, individual differences between participants). In the proposed R03, we will use 7 existing datasets from the PI’s K23 activities, mentors’ clinical trials, and publicly available databases to examine PA measurement reactivity among women in midlife with elevated CVD risk (e.g., obesity, hypertension; N = 800). Using a coordinated analysis approach, we will employ multilevel modeling techniques to achieve the following aims: (1) To characterize midlife women’s PA measurement reactivity across four PA outcomes: steps, minutes of light activity, minutes of MVPA, and minutes spent in sedentary behavior, (2) To determine whether the presence or extent of measurement reactivity differ based on study characteristics such as research design (i.e., observation only vs. PA assessment pre-intervention) and PA monitoring procedures (i.e., research-grade accelerometers vs. commercially available wearables), and (3) To determine whether the presence or extent of measurement reactivity differ based on medical or psychological characteristics, including BMI, motivation to engage in PA, and depressive symptoms. This work will generate preliminary data to identify circumstances associated with problematic levels of PA measurement reactivity among women in midlife and potential targets for reducing it in an at-risk group. This R03 thus represents an innovative extension of the PI’s K23 program that will leverage institutional resources and insights to date and contribute to the scientific rigor of research in the fields of PA measurement and intervention. Consequently, this work will support the PI’s development as a leading independent investigator, focused on promoting PA to reduce CVD risk in at-risk populations.

抽象的中年时期（40-60 岁）女性的心血管疾病 (CVD) 风险大幅增加。中年期间增加体力活动（PA）可以减轻这些风险，并且迫切需要可以减少参与该人群的 PA 测量反应障碍的研究。由于引入 PA 测量而导致 PA 参与度发生变化，可能会导致目标出现偏差对 PA 的评估对于评估 PA 努力的促进至关重要，具体而言，即 PA 测量。反应性可能会在监测期早期对 PA 进行通胀估计，并导致错误的结论然而，目前有证据表明中年女性等高危人群参与 PA 的情况。支持 PA 测量反应性作为 PA 研究中的一个关键混杂因素的观点是复杂的，包括初步的来自 PI 的 K23 奖的证据拟议的研究旨在解决三个关键局限性。现有工作：(1) 重点关注心血管疾病风险较低的儿童或健康的年轻人，(2) 缺乏反应性定义和最有可能受到影响的 PA 结果的一致性（例如，每天中度至剧烈活动的步数与分钟数 [MVPA]），以及 (3) 缺乏对因此，反应性可能是最有影响力的环境（例如，研究设计、个体之间的差异）在拟议的 R03 中，我们将使用 PI 的 K23 活动、导师的 7 个现有数据集。用于检查女性 PA 测量反应性的临床试验和公开数据库 CVD 风险升高的中年人（例如肥胖、高血压；N = 800）。方法中，我们将采用多层次建模技术来实现以下目标：（1）描述中年女性在四种 PA 结果中的 PA 测量反应性：步数、分钟数轻度活动、MVPA 分钟数和久坐行为所花费的分钟数，(2) 确定是否基于研究等研究特征的测量重差异活动的存在或程度设计（即仅观察与干预前的 PA 评估）和 PA 监测程序（即研究级加速度计与市售可穿戴设备），以及 (3) 确定是否测量反应的存在或程度因医学或心理学而异特征，包括 BMI、参与 PA 的动机以及抑郁症状。生成初步数据以确定与有问题的 PA 水平相关的情况测量中年女性的反应性以及降低高危人群反应性的潜在目标。因此，R03 代表了 PI K23 计划的创新延伸，该计划将利用机构迄今为止的资源和见解，并为 PA 领域的科学研究做出贡献通过测量和干预，这项工作将支持 PI 作为领导者的发展。独立研究者，专注于促进 PA 以降低高危人群的 CVD 风险。