EFR3: Novel gatekeeper of cell proliferation

EFR3：细胞增殖的新型看门人

• 批准号: DP240102729
• 负责人: Prof Janni Petersen
• 金额: $ 37.38万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102729
• 关键词: EFR3; Novel; gatekeeper; cell; proliferation

This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cell survival. This project advances basic and applied biology. Its outcomes will be relevant to several research areas and industries, specifically to the propagation of cell cultures that nowadays contributes to the production of a myriad of biotechnical and pharmaceutical commodities.

这个跨学科的跨机构项目使用前沿质谱和酵母遗传模型来增强对真核细胞细胞增殖常见的基本信号传导机制的了解。这项研究以广泛的初步数据为基础，该数据确定了新型的能量压力控制点，将洞悉细胞增殖的养分胁迫控制的关键和保守特征，以确保细胞存活。该项目推进了基本和应用生物学。它的结果将与几个研究领域和行业有关，特别是与当今的细胞培养物的传播相关，这些细胞培养物有助于生产无数的生物技术和药品。