Microbiome Multi-Omics and Cognitive Decline in Latinos

微生物组多组学和拉丁裔认知能力下降

• 批准号: 10661289
• 负责人: Natalia Palacios
• 金额: $ 202.07万
• 依托单位: UNIVERSITY OF MASSACHUSETTS LOWELL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661289
• 关键词: Acculturation; Address; Adult; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Amino Acids; Amyloid; Area; Behavioral; Bifidobacterium; Bile Acids; Bioinformatics; Biological; Boston; Brain; Branched-Chain Amino Acids; Cholesterol Homeostasis; Cholic Acids; Chronic Disease; Cognition; Cognitive; Communication; Data; Dementia; Deoxycholic Acid; Diagnosis; Diet; Disparity; Ecosystem; Education; Epidemic; Epidemiology; Escherichia; Feces; Functional disorder; Funding; Future; Health; Human; Impaired cognition; Inflammation; Intervention; Investigation; Isoleucine; Latino Population; Leucine; Life Style; Light; Longitudinal Studies; Longitudinal cohort; Magnetic Resonance Imaging; Maps; Measures; Metabolic; Metabolic syndrome; Metagenomics; Microbial Taxonomy; Minority Groups; Nature; Neurocognitive; Neuroepidemiology; Neurotransmitters; Not Hispanic or Latino; Outcome; Participant; Pathway interactions; Pattern; Peptides; Plasma; Population; Prevention; Prevotella; Production; Prospective Studies; Proteins; Public Health; Puerto Rican; Research; Resolution; Risk; Role; Stress; Structure; Study of Latinos; United States National Institutes of Health; Update; Validation; Valine; Volatile Fatty Acids; Vulnerable Populations; brain health; cognitive function; cognitive testing; cohort; community based research; cytokine; dementia risk; dietary; fatty acid metabolism; gamma-Aminobutyric Acid; gut microbiome; gut microbiota; health disparity; high risk; metabolomics; microbial; microbial community; microbiome; microbiome composition; multiple omics; neurofilament; neuroinflammation; nonalzheimer dementia; pre-clinical; precision medicine; predictive modeling; prevent; prospective; response; social; social disparities; stool sample; tool development; translational impact

Project Summary/Abstract The epidemic of Alzheimer’s disease and associated cognitive decline is a critical public health challenge that will grow as the US and world populations age. US Latinos, and particularly Puerto Ricans, suffer a disproportionate burden: Puerto Ricans are at approximately double the risk of Alzheimer’s disease compared to non-Hispanic whites. Increasing evidence points to the bi-directional communication between the brain and the gut microbiome--the gut-microbiome-brain-axis--as an important factor in brain health. Despite the promising nature of this field, limited research has been done on the association between the microbiome and cognition, particularly in minority populations. Mapping the relationship between the gut microbiome and cognition in vulnerable populations such as US-based Puerto Ricans, with excess Alzheimer disease, is key to addressing current and preventing future health disparities. The proposed project will be the largest study in a minority population to date, and the first in Puerto Ricans, on the role of the gut microbiome in cognitive decline. The proposed study will leverage an established cohort--the Boston Puerto Rican Health Study (BPRHS), a longitudinal cohort with 1499 participants at baseline, three completed waves of cognitive assessments, recent MRI, and extensive covariate data. This project will develop a framework of how the human gut microbiome multi-omics contributes to cognitive trajectory and markers of AD/ADRD in Latinos. It will leverage previously collected stool samples, MRI, and 14 years of longitudinally collected data on cognition and covariates among participants of the BPRHS. Key strengths of this proposal include: 1) leverage of a large, NIH-funded prospective study of Boston area Puerto Ricans (P01AG023394, P50HL105185, R01AG055948), an underserved and understudied minority population 2) validated and updated prospective data on cognitive decline, MRI, dietary and lifestyle covariates 3) the interdisciplinary expertise of the research team, including chronic disease epidemiology, community-based research, cognition, the microbiome, MRI and predictive modeling. This study will have a strong translational impact, enabling future microbiome-targeted interventions to promote cognitive health and will contribute to the development of tools needed for a preclinical diagnosis and/or treatment of cognitive decline and Alzheimer’s disease among this vulnerable population.

项目概要/摘要 阿尔茨海默病的流行和相关的认知能力下降是一项重大的公共卫生挑战， 随着美国和世界人口老龄化，美国拉丁美洲人，特别是波多黎各人将遭受老龄化。 不成比例的负担：波多黎各人患阿尔茨海默病的风险大约是其他人的两倍 越来越多的证据表明大脑和非西班牙裔白人之间存在双向交流。 尽管肠道微生物组——肠道-微生物组-大脑轴——是大脑健康的一个重要因素。 鉴于该领域的性质，关于微生物组与微生物之间的关联的有希望的研究有限。 认知，特别是在少数群体中，绘制肠道微生物组与认知之间的关系。 患有阿尔茨海默病的美国波多黎各人等弱势群体的认知能力是关键 拟议的项目将是解决当前和预防未来健康差距的最大研究。 迄今为止，在少数群体中，也是第一个在波多黎各人中研究肠道微生物组在认知中的作用的研究 拟议的研究将利用现有的队列——波士顿波多黎各健康研究。 (BPRHS)，一个纵向队列，基线时有 1499 名参与者，完成了三个认知波 评估、最近的 MRI 和广泛的协变量数据。 该项目将开发一个框架，说明人类肠道微生物组多组学如何促进认知 它将利用之前收集的粪便样本、MRI 和 14 来确定拉丁裔 AD/ADRD 的轨迹和标记。 多年来纵向收集的 BPRHS Key 参与者的认知和协变量数据。 该提案的优点包括：1）利用 NIH 资助的波士顿地区波多黎各地区大型前瞻性研究 黎加人 (P01AG023394、P50HL105185、R01AG055948)，服务不足且研究不足的少数群体 2) 验证和更新关于认知衰退、MRI、饮食和生活方式协变量的前瞻性数据 3) 研究团队的跨学科专业知识，包括慢性病流行病学、基于社区的 这项研究将具有很强的转化性。 影响，使未来以微生物组为目标的干预措施能够促进认知健康，并将有助于 开发临床前诊断和/或治疗认知衰退和阿尔茨海默病所需的工具 这些弱势群体中的疾病。