Exposure to Per- and Polyfluoroalkyl Substances and Child Lung Function

接触全氟烷基和多氟烷基物质与儿童肺功能

基本信息

批准号：
10658859
负责人：
Jennifer Ann-Marie Oliver
金额：
$ 2.91万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10658859
关键词：
6 year old Address Adolescence Adolescent Adult Adverse effects Affect Airway Resistance Alveolar Animals Asthma Biometry Birth Blood Chemical Exposure Chemicals Child Childhood Chronic Disease Chronic Obstructive Pulmonary Disease Cohort Studies Complex Data Development Early Intervention Environment Environmental Exposure Epidemiology Exposure to First Pregnancy Trimester Forced expiratory volume function Funding Future Goals Growth Growth and Development function Health Human body Impairment Individual Industrial Product Intervention Life Life Cycle Stages Literature Longevity Low Birth Weight Infant Lung Massachusetts Measurement Measures Medicine Mentorship Mothers National Institute of Environmental Health Sciences Organic Chemicals Outcome Pathway interactions Pediatric epidemiology Perinatal Epidemiology Plasma Poly-fluoroalkyl substances Population Predisposition Pregnancy Pregnant Women Premature Mortality Prevention strategy Public Health Pulmonology Quality of life Regulation Research Risk Reduction Statistical Methods Time Toxic effect Training Training and Education United States National Institutes of Health Vaccines Vital capacity Wheezing asthmatic career cohort consumer product critical period early adolescence early childhood early life exposure early onset environmental chemical epidemiology study health communication improved in utero lung development lung health lung maturation lung volume prenatal prenatal exposure pulmonary function recruit respiratory respiratory health response surfactant function

项目摘要

PROJECT SUMMARY/ABSTRACT Per- and polyfluoroalkyl substances (PFAS) are a group of persistent and bioaccumulative chemicals used in a large number of industrial and consumer products that have been measured in blood of more than 97% of the population above 6 years in nationally representative studies. PFAS are commonly assessed as individual chemicals, but exist as diverse and complex chemical mixtures of known and unknown compounds in the environment and human body. Due to rapid lung development and growth that occurs during the prenatal period and childhood, these developmental periods may be particularly susceptible to the adverse effects of PFAS on lung function. Impaired lung function in childhood is associated with impaired lung function in adulthood, which in turn is associated with early onset of chronic diseases and premature mortality from all causes. Animal studies suggest PFAS adversely affect lung maturation, surfactant function, and alveolar integrity, but there are limited epidemiological studies exploring the association between PFAS and lung function in children. The findings from the previous epidemiological studies are limited, inconclusive, and lack longitudinal assessment. Our study proposes to investigate the effects of PFAS and PFAS mixtures on children’s lung function in Project Viva, an ongoing pre-birth cohort study of 1116 mother-child pairs recruited in Massachusetts between 1999 and 2002. Specifically, we will 1) evaluate the association between prenatal exposure to PFAS and PFAS mixtures and lung function in mid-childhood, and 2) assess the association between mid-childhood PFAS and PFAS mixtures and lung function in mid-childhood and adolescence. To our knowledge, this will be the first study to assess the effects of PFAS mixtures on lung function in children, and the longitudinal effects of these chemicals on lung health. As we seek to identify potential causal pathways for the impact of PFAS on lung function during developmental periods, our findings may support PFAS mitigation and regulation, and the development of targeted interventions to reduce the risk of lung illness later in life.

项目概要/摘要全氟烷基物质和多氟烷基物质 (PFAS) 是一组持久性和生物累积性化学品，用于大量工业和消费品已在97%以上的血液中进行了测量在全国代表性研究中，6 岁以上人群通常被视为个体。化学物质，但以已知和未知化合物的多样化和复杂的化学混合物形式存在由于胎儿时期肺部的快速发育和生长。和儿童时期，这些发育时期可能特别容易受到 PFAS 对身体的不利影响。儿童期肺功能受损与成年期肺功能受损有关。反过来，与各种原因引起的慢性疾病的早期发作和过早死亡有关。表明 PFAS 对肺成熟、表面活性剂功能和肺泡完整性产生不利影响，但影响有限流行病学研究探讨了 PFAS 与儿童肺功能之间的关系。以往的流行病学研究有限，缺乏结论，并且缺乏纵向评估。提议在 Viva 项目中研究 PFAS 和 PFAS 混合物对儿童肺功能的影响，该项目是一项 1999 年至 2002 年间在马萨诸塞州招募的 1116 对母子对正在进行的产前队列研究。具体来说，我们将 1) 评估产前接触 PFAS 和 PFAS 混合物之间的关联儿童中期的肺功能，2) 评估儿童中期 PFAS 和 PFAS 混合物之间的关联据我们所知，这将是第一项评估儿童中期和青春期肺功能的研究。 PFAS 混合物对儿童肺功能的影响，以及这些化学物质对肺的纵向影响当我们寻求确定 PFAS 对肺功能影响的潜在因果途径时。发展阶段，我们的研究结果可能支持 PFAS 的缓解和监管，以及有针对性的干预措施，以降低晚年患肺部疾病的风险。