Measuring Human Exposure to PBDEs

测量人体接触多溴联苯醚的情况

• 批准号: 7892650
• 负责人: Thomas F Webster
• 金额: $ 37.14万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-06 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7892650
• 关键词: Address; Adult; Age; Air; American; Animals; Area; Asians; Birth; Blood; Blood specimen; Body Burden; Boston; Breathing; Bromine; Carpet; Chemicals; Child; Country; Cryptorchidism; Data; Data Set; Diet; Dose; Dust; Electronics; Environment; European; Exposure to; Flame Retardants; Fluorescence; Furniture; General Population; Hand; Health; Home environment; Hormonal; Hormones; Household; Human; Human body; Massachusetts; Measurement; Measures; Modeling; Outcome; Participant; Pattern; Polychlorinated Biphenyls; Population; Questionnaires; Recruitment Activity; Relative (related person); Reporting; Reproductive system; Research; Research Design; Risk; Roentgen Rays; Route; Sampling; Serum; Signal Transduction; Source; Statistical Models; Time; United States; United States Environmental Protection Agency; Variant; Venous blood sampling; Workplace; air sampling; base; cohort; consumer product; design; exposed human population; hazard; improved; metropolitan; phenyl ether; physical model; polyurethane foam; public health relevance; response

DESCRIPTION (provided by applicant): Polybrominated diphenyl ethers (PBDEs) are commonly used as fire retardants in consumer products such as electronics and furniture containing polyurethane foam. Structurally similar to polychlorinated biphenyls (PCBs), several PBDE congeners perturb hormonal signaling and are toxic to the nervous and reproductive systems of developing animals. Human body burdens have increased over the last several decades and are highest in the United States (US), where levels are more than an order of magnitude higher than in Asian and European populations in which PBDE levels are associated with decreased birth outcomes and increased risk of cryptorchidism. Diet and the indoor environment (dust, air) are likely important factors that contribute to personal exposure, but the predominant route of exposure is not known. Indeed, in a 2006 report on PBDEs, the US Environmental Protection Agency identified the "need for improved understanding of exposure to these chemicals and the associated hazards." We propose a comprehensive approach to examining human exposure to PBDEs. The proposed study has been designed to address a range of important gaps that exist in the PBDE research base and would represent the most complete assessment of human PBDE exposure to date. In a cohort of fifty Massachusetts residents, we will conduct three rounds of exposure sampling (at six month intervals) and examine three microenvironments: the home, workplace, and car. During each sampling round, we will concurrently assess PBDEs at multiple steps of the exposure-response continuum by (a) estimating the PBDE content of consumer products (potential sources) using a portable x-ray fluorescence analyzer, (b) measuring PBDEs in dust collected from the home, workplace and car (key microenvironments), (c) measuring PBDEs in personal air and hand-wipe samples (personal exposure), (d) measuring PBDEs in human serum (total absorbed dose), and (e) measuring hormone levels (potential early effects). This powerful study design will generate a rich dataset of repeated exposure measures and allow for a longitudinal assessment of PBDE body burden and hormone levels. Accordingly, the proposed research will provide a more complete understanding of how PBDEs enter the indoor environment, how the general population is exposed to PBDEs, which exposure routes contribute most to total absorbed dose, and the extent to which PBDE exposure may be associated with changes in hormone levels in humans. PUBLIC HEALTH RELEVANCE: The levels of polybrominated diphenyl ethers (PBDEs) found in the bodies of Americans have increased for decades and are an order of magnitude higher than in other countries where a few studies have found associations with adverse health outcomes. Although the indoor environment is hypothesized to be the major source of these flame retardants, the sources and routes of human exposure are not well understood. The proposed project will provide a more complete understanding of how PBDEs enter the indoor environment, how people are exposed, and the extent to which they may be associated with human hormones levels.

描述（由申请人提供）：多溴二苯基醚（PBDE）通常用作消费产品中的阻燃剂，例如电子和含有聚氨酯泡沫的家具。结构上类似于多氯联苯（PCB），几个PBDE同类物扰动激素信号传导，对正在发育的动物的神经和生殖系统有毒。在过去的几十年中，人体负担增加了，在美国（美国）最高，在美国，水平高于亚洲和欧洲人口的数量级，而PBDE水平与降低的出生结果和加密性的风险增加有关。饮食和室内环境（灰尘，空气）可能是导致个人暴露的重要因素，但尚不清楚暴露途径。确实，在2006年关于PBDE的报告中，美国环境保护局确定了“对这些化学物质和相关危害的接触的需求”。我们提出了一种研究人类对PBDES的侵害的全面方法。拟议的研究旨在解决PBDE研究基础中存在的一系列重要差距，并代表了迄今为止人类PBDE暴露的最完整评估。在一个五十名马萨诸塞州居民的队列中，我们将进行三轮暴露采样（以六个月的间隔），并检查三个微环境：家庭，工作场所和汽车。在每次抽样期间，我们将通过（a）使用便携式X射线荧光分析仪估算消费产品（潜在来源）的PBDE含量（a），（b）从家庭，工作场所和汽车的固定型（键）（键）（c）（b）测量PBDE的PBDE（潜在的PBD），（b）在家庭，工作场所和汽车中（键入的Microenvirieen）（C）（c）（c）（b）暴露），（d）测量人血清中的PBDE（总吸收剂量）和（e）测量激素水平（潜在的早期作用）。这项强大的研究设计将产生丰富的重复暴露措施数据集，并允许对PBDE身体负担和激素水平进行纵向评估。因此，拟议的研究将对PBDES进入室内环境，一般人群如何暴露于PBDE的研究提供更全面的了解，PBDES的暴露途径对总吸收剂量有最大的贡献以及PBDE暴露的程度可能与人类激素水平的变化有关。公共卫生相关性：在美国人体内发现的多溴二苯基醚（PBDE）的水平已有数十年来增加，并且比其他一些研究发现与不良健康结果有关的其他国家高。尽管假设室内环境是这些阻燃剂的主要来源，但人类暴露的来源和途径尚不清楚。拟议的项目将对PBDE的进入室内环境，人们的暴露方式以及与人类荷尔蒙水平相关的程度提供更完整的了解。