Development Influences of Sexual & Romantic Relationships on Adolescnt Male STI R

性发育的影响

• 批准号: 7962283
• 负责人: MARY A. OTT
• 金额: $ 5.78万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7962283
• 关键词: 17 year old; Address; Adolescence; Adolescent; African American; Age; Alcohol or Other Drugs use; American; Behavioral; Biological; Biological Factors; Cell Count; Cellular Phone; Characteristics; Chlamydia trachomatis; Clinical; Coital Frequency; Coitus; Communities; Computer Assisted; Data; Development; Electronics; Enrollment; Epidemiology; Ethnic Origin; Event; Infection; Intervention; Interview; Knowledge; Laboratories; Latino; Length; Local Microbicides; Masculine; Mediating; Moods; Mycoplasma genitalium; Natural History; Neighborhoods; Neisseria gonorrhoeae; Nonspecific urethritis; Organism; Participant; Pattern; Prevalence; Prevention; Public Health; Pyuria; Race; Recruitment Activity; Reporting; Research; Risk; Risk Factors; Sampling; Sex Behavior; Sexual Partners; Sexually Transmitted Diseases; Symptoms; Testing; Time; Trichomonas vaginalis; Ureaplasma urealyticum; Urethritis; Urine; condoms; diaries; experience; follow-up; interest; male; men; pathogen; psychologic; sexual relationship; social

The long-term objective of Project 3 is to characterize the natural history and developmental epidemiology of sexually transmitted infections (STI) among young men from middle to late adolescence and into young adulthood. The,specific aims are: (1) To describe adolescent men's patterns of infection by 5 sexually transmitted organisms (C. trachomatis trachomatis. Neisseria gonorrhoeae. Trichomonas vaginalis. Mycoplasma genitalium, Ureaplasma urealyticum, biovar 2), and non-gonococcal urethritis as a function of time; (2) To describe adolescent men's patterns of infection acquisition, organism shedding, symptom development, and pyuria for each target organism using event-contingent every other day samples for 14 days; And (3) To describe the psychological, interpersonal, social and behavioral phenomena associated with occurrence of sexual events using electronic cell phone diary reports among adolescent men. Through the Clinical Core, we will recruit 234 African American, Latino and Euro-American young men, ages 14-17 at enrollment, from a community with high STI prevalence. Participants will be followed for up to 57 months. In conjunction with the Laboratory Core, we will test monthly surveillance urine samples and more frequent event-contingent samples with PCR and cell counts to characterize the natural history ofthe above 5 STI and NGU across adolescence. Quarterly audio computer assisted self interviews (ACASI) will be used to characterize demographic, behavioral, biological, and socio-cultural correlates of STI acquisition and sequence. Daily cell phone diaries will be used to describe the psychological, interpersonal, and behavioral phenomena associated with specific sexual events and STI. The proposed research addressed three priorities related to STI: (1) A focus on adolescents, (2) The interactions among different organisms, including emerging pathogens such as M. genitalium and (3) the provision of key developmental epidemiology and behavioral data to inform interventions.

项目3的长期目标是表征自然历史和发展流行病学 从青春期到后期到年轻人的年轻人中的性传播感染（STI） 成年。特定的目的是：（1）通过性5个描述青春期男性的感染模式 透射的生物（沙眼曲盘，沙眼。淋病奈瑟氏菌。 分枝杆菌生殖器，尿素骨尿素，生物娃娃2）和非造成尿道炎的作用 时间; （2）描述青春期男性的感染习得，有机体脱落，症状 每隔一天的样本使用事件持有剂的开发和每种目标生物的脓尿 天; （3）描述相关的心理，人际，社会和行为现象 在青春期男性中使用电子手机日记报告发生性事件。通过 临床核心，我们将招募234名非裔美国人，拉丁裔和欧美年轻人，年龄14-17岁 从具有高性病的社区的入学人数。参与者将被跟踪长达57个月。在 与实验室核心的结合，我们将测试每月监视尿液样本，更频繁 带有PCR和细胞计数的事件诱导样品以表征上述5 STI的自然历史 和NGU在青春期。季度音频计算机辅助自我采访（ACASI）将用于 表征人口，行为，生物学和社会文化的相关性， 顺序。每日手机日记将用于描述心理，人际关系和行为 与特定的性事件和STI相关的现象。拟议的研究解决了三个 与STI有关的优先级：（1）关注青少年，（2）不同生物体之间的相互作用， 包括新兴的病原体，例如生殖器和（3）提供关键发育 流行病学和行为数据，以告知干预措施。