Supplement to grant: Development of Dendrimer and Combination Microbicides

补助金补充：树枝状聚合物和组合杀菌剂的开发

• 批准号: 7962687
• 负责人: Jeremy Paull
• 金额: $ 41.38万
• 依托单位: STARPHARMA, LTD
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-03 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7962687
• 关键词: Acids; Antiviral Agents; Award; Bacteria; Data; Dendrimers; Development; Drug Formulations; Funding; Future; Gel; Grant; Investigation; Lactic acid; Modeling; Mus; Outcome; Research Personnel; SPL7013; Sheep; Simplexvirus; Vagina; Virus; Work; antimicrobial; base; cofactor; meetings; microbicide; programs

(supplied by IC): The proposed supplement will have a significant impact on the wrapping up of this IPCP-HTM award. The investigator and the IPCP-HTM team has been very proactive in responding to unexpected outcomes during this award and have actively worked toward the development of a viable dendrimer-based microbicide. Examples are the discovery and need to synthesize and formulate the new dendrimer microbicide SPL8240. This new dendrimer microbicide arose from the observations of stability issues of SPL7013 in acid conditions and the efforts of Project 2. The new dendrimer is more stable and retains antiviral activity under vaginal conditions. It was discovered in year 5 of the award. The formulation of lactic acid and SPL8240 in gels and rings is also a critical development step that needs to be brought to conclusion. This need arose from the discovery that lactic acid is a potent cofactor in formulations, displaying broad anti-microbial activity against viruses and bacteria. This is a significant finding and meets Program's priorities to develop broadly active microbicides. The supplement funding will solidify initial observations and determine whether lactic acid can be a microbicide and the utility of the new dendrimer SPL8240. The investigation ofSPL8240 and lactic acid in the murine HSV model and the sheep model are critical to further wrapping up the activities of this IPCP-HTM. Together these activities in toto act to allow the IPCP-HTM team to wrap-up the IPCP-HTM and identify future next steps with sufficient preliminary data to allow future funding In Program¿s opinion all of the above data will be critical in determining the next steps, if any, that are needed for successful development of lactic acid and dendrimers as a microbicide.

（由IC提供）： 拟议的补充剂将对该IPCP-HTM奖的总结产生重大影响。 调查员和IPCP-HTM团队在回应意想不到的方面非常积极 该奖项期间的成果，并积极致力于发展可行的 基于树枝状聚合物的菌心。示例是发现，需要合成和制定 新的树枝状聚合物杀菌剂SPL8240。这种新的树枝状聚合物杀菌剂来自于观察 SPL7013在酸性条件下的稳定性问题和项目2的努力。新的树突聚合物更多 在阴道条件下稳定并保留抗病毒活性。它是在该奖项的第五年发现的。 凝胶和环中乳酸和SPL8240的配方也是一个关键的发展步骤 需要得出结论。这种需求是从发现乳酸是有效的 公式中的辅因子，对病毒和细菌表现出广泛的抗菌活性。这是一个 重大发现并符合计划开发广泛活跃的微生物的优先事项。 补充资金将巩固初始观察结果，并确定乳酸是否可以是 新树状聚合物SPL8240的菌心和效用。 SPL8240和乳酸的投资 在Murine HSV模型和绵羊模型中，对于进一步结束活动至关重要 IPCP-HTM。将这些活动结合在一起，以允许IPCP-HTM团队总结IPCP-HTM 并使用足够的初步数据确定未来的下一步，以允许未来的资金 在计划的意见中，以上所有数据对于确定下一步（如果有）至关重要 成功开发漆酸和树枝状聚合物作为微生物剂所需。