ENHANCEMENT OF THE CPRC-SPF RHESUS MONKEY PROGRAM

加强 CPRC-SPF 恒河猴计划

• 批准号: 7900110
• 负责人: Edmundo Nelson Kraiselburd
• 金额: $ 73.21万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-05 至 2011-09-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7900110
• 关键词: ENHANCEMENT; CPRC; SPF; RHESUS; MONKEY

DESCRIPTION (provided by applicant): The objective of this proposal is to maintain a closed specific pathogen-free (SPF) rhesus macaque breeding colony program at the Sabana Seca Field Station of the Caribbean Primate Research Center (CPRC). The founding stock of genetically-characterized Indian-origin monkeys will be donated by CPRC and consists of approximately 300 SPF rhesus macaques. Animals from this closed colony will be housed in reproduction corncribs, and will be quarterly tested for the presence of four target viruses (Herpes B, STLV-1, SIV and SRV). To characterize the colony and to optimize the structure of its breeding groups, a panel of highly polymorphic genetic markers will be used maximizing the level of their genetic heterogeneity. It is projected the program will produce a total offspring of 584 SPF rhesus macaques to help meet the increased demand for these animals. At the end of this grant, it is expected that this program will produce and will make available to PHS-funded investigators about 180 MHC typed SPF animals/year, thus attaining self-sufficiency. CPRC will continue to make significant contributions to AIDS and to other research programs by providing high quality and healthy SPF rhesus monkeys to NIH-sponsored research projects.

描述（由申请人提供）：该提案的目的是维持在加勒比灵长类动物研究中心（CPRC）的Sabana Seca Field Station（CPRC）的Sabana Seca野战站的封闭式猕猴猕猴育种菌落计划。 CPRC将捐赠遗传特征的印度猴子猴子的创始库存，由大约300个SPF恒河猕猴组成。该封闭菌落中的动物将容纳在繁殖玉米中，并将每季度测试四种目标病毒（疱疹B，STLV-1，SIV和SRV）。为了表征菌落并优化其育种群的结构，将使用一系列高度多态性遗传标记，以最大程度地提高其遗传异质性水平。预计该计划将产生584个SPF恒河猕猴的总后代，以帮助满足对这些动物的需求增加。在这笔赠款结束时，预计该计划将生产并将向PHS资助的调查人员提供约180个MHC的SPF动物/年，从而获得自给自足。 CPRC将通过为NIH赞助的研究项目提供高质量和健康的SPF恒河猴，为艾滋病和其他研究计划做出重大贡献。