ENHANCEMENT OF THE CPRC-SPF RHESUS MONKEY PROGRAM: AIDS THERAPEUTIC AGENT

加强 CPRC-SPF 恒河猴计划：艾滋病治疗剂

• 批准号: 8359537
• 负责人: Edmundo Nelson Kraiselburd
• 金额: $ 40.35万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359537
• 关键词: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Animals; Biomedical Research; Breeding; Complex; Female; Future; Infant; Island; Macaca; Macaca mulatta; Maintenance; Monkeys; Production; Research; Retroviridae; SIV; Surveys; Therapeutic Agents; United States National Institutes of Health; Virus; cohort; immature animal; meetings; offspring; programs; social group

DESCRIPTION (Provided by applicant): The objective of this proposal is to enhance the existing SPF rhesus macaque supply and breeding colony program at the SSFS of the CPRC. This program will use genetically characterized, major histocompatability complex (MHC)-typed, Indian-origin monkeys from established social groups obtained from the CPRC's free-ranging colony on the island of CS. The CPRC will donate the founding stock for the colony, which consists of 102 adult and 21 juvenile females and minimum of 20 sires. Previous surveys have shown that the Cayo Santiago macaques are free of several important viruses including retroviruses, and that the majority of immature animals are negative for B virus. About 20-25% of these monkeys are also Mamu-A*01 positive. Currently, there is a shortage of SPF rhesus monkeys for biomedical research and the demand for these animals is expected to increase dramatically in the future. The establishment and maintenance of this expanded program at SSFS will help meet the increased demand for both SPF (B virus, SRV-D, SIV, and STLV-l-free) and Mamu-A*01 positive rhesus monkeys. MHC-typing and selective breeding will be used to increase the production of SPF Mamu-A*01 positive offspring. The founding cohort is expected to produce a minimum of 70 infants during the first year and an estimated total offspring of about 400 SPF animals in five years. By Year 6 the program should be self-supporting. The CPRC's program will make a significant contribution to advancing biomedical research, and in particular to AIDS research by providing high quality and healthy SPF rhesus monkeys to NIH-sponsored research programs.

描述（由申请人提供）：该提案的目的是增强CPRC SSF的现有SPF恒河猕猴供应和育种殖民地计划。 该计划将使用从CPRC岛上从CS的自由群体获得的成熟社会群体中获得的基因表征，主要的组织相容性复合物（MHC）的印度 - 原始猴子。 CPRC将捐赠该殖民地的创始库存，该库由102名成年和21名少年女性组成，至少为20名父亲。 先前的调查表明，圣地亚哥猕猴没有多种重要病毒，包括逆转录病毒，大多数未成熟动物对B病毒呈阴性。 这些猴子中约有20％的猴子也为MAMU-A*01阳性。 目前，SPF恒河猴的生物医学研究缺乏，对这些动物的需求预计将来会大大增加。 SSFS的扩展计划的建立和维护将有助于满足SPF（B病毒，SRV-D，SIV和STLV-L-Free）和Mamu-A*01阳性恒河猴的需求增加。 MHC型和选择性育种将用于增加SPF Mamu-A*01阳性后代的产生。 预计建立队列将在第一年至少产生70名婴儿，估计在五年内约有400只SPF动物的总后代。到6年级，该计划应自给自足。 CPRC的计划将通过为NIH赞助的研究计划提供高质量和健康的SPF Rhesus Monkeys来推进生物医学研究，尤其是对AIDS研究的重要贡献。