Skeletal, Craniofacial and Oral Biology Training Grant

骨骼、颅面和口腔生物学培训补助金

基本信息

批准号：
10661130
负责人：
Mina Mina
金额：
--
依托单位：
UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10661130
关键词：
Area Bioinformatics Biology Cancer Biology Cellular biology Clinical Clinical Research Collaborations Computational Biology Dental Dental Residencies Dental Schools Development Plans Doctor of Philosophy Ensure Environment Evolution Faculty Foundations Funding Gene Expression Regulation Genomic medicine Genomics Grant Health Immunology Individual Institution Interdisciplinary Study K-Series Research Career Programs Laboratories Medicine Microbiology Oral Preparation Regenerative Medicine Research Research Activity Research Training Science Scientist Solid The Jackson Laboratory Tissue Engineering Training Training Programs Training Support Translational Research Underrepresented Minority United States career career development craniofacial flexibility improved microbiome oral biology patient oriented research programs recruit skeletal stem cell biology success symposium teaching laboratory

项目摘要

Project Summary: This is a proposal for the continuation of the Institutional Training Program in Skeletal, Craniofacial and Oral Biology at the UConn Health, School of Dental Medicine as a T90/R90 program. It is intended to help meet the substantial need for independent scientists trained in research related to improving oral, dental and craniofacial health in the United States. The program has and will continue to train scholars (DMD and non-DMD) who are competent as clinicians and independent scientists, who are able to initiate and maintain funded research programs, who understand multidisciplinary research and who are prepared for the evolution of their research into new directions. Areas of research training include Tissue Engineering and Regenerative Medicine, Cell and Cancer Biology, Computational Biology, Genomics and Bioinformatics, Craniofacial and Skeletal Biology, Gene Regulation, Immunology, Microbiome/Microbiology, Oral Biology, Stem Cell Biology, and clinical and translational research. The major tracks of the training program are the (i) DMD/PhD (7-8 yrs of training with 3- 5 yrs of support from this training grant; 4 present trainees, 1-4 (depending on success of F30s) additional trainees requested over five yrs), (ii) PhD (4-5 yrs of training with 3 yrs of support; 3 present trainees, 6 additional trainees requested), (iii) postdoctoral research (3 yrs training and support; 3 present trainees, 5 additional trainees requested) and (iv) non-citizen PhD trainees (with DDS degrees) (3-5 yrs of training with 3 yrs of support; 1 present trainees 2 additional trainees requested). We will be training individuals with a broad range of backgrounds, from those with BS/BA degrees to those who have completed PhD and/or dental residency training. To provide a solid, common foundation for our scholars/trainees, we have developed Core Activities required of all trainees in all training tracks. We are introducing several new program features to (i) insure training milestones are achieved, (ii) facilitate preparation of F and K awards by trainees, (iii) better integrate clinical and research training for our DMD/PhDs to enhance transition into an academic career, and (iv) career development plans for teaching and laboratory management. UConn Health has a dynamic group of faculty in various areas of research with highly successful collaborations among faculty throughout the Schools of Dental Medicine and Medicine and The Jackson Laboratory for Genomic Medicine. The Biomedical Science PhD program graduate faculty, active and new institutional research centers and clinical programs provide contemporary laboratory, translational and patient oriented research opportunities that enable a diversified training environment for the program tracks, allow flexibility for the individual needs of trainees, and ensure successful progress through the tracks. The institution has vigorous trainee recruitment programs. Several are directed towards under-represented minority candidates. We will continue to provide training that is tailored to each candidate through symposia, seminars, courses, clinical research centers and collaborative research activities which are integrated both within individual tracks and amongst all the tracks of the program.

项目概要：这是关于继续骨骼、颅面和口腔机构培训计划的提案康涅狄格大学健康学院牙科医学院的生物学作为 T90/R90 项目。其目的是帮助满足大量需要接受过与改善口腔、牙科和颅面相关研究培训的独立科学家在美国的健康状况。该计划已经并将继续培训以下学者（DMD 和非 DMD）：有能力作为临床医生和独立科学家，能够启动和维持资助的研究项目，了解多学科研究并为研究的发展做好准备进入新的方向。研究培训领域包括组织工程和再生医学、细胞和癌症生物学、计算生物学、基因组学和生物信息学、颅面和骨骼生物学、基因调控、免疫学、微生物组/微生物学、口腔生物学、干细胞生物学以及临床和转化研究。培训计划的主要轨道是 (i) DMD/PhD（7-8 年的培训，其中 3- 此培训补助金提供 5 年支持； 4 名现有学员，额外 1-4 名（取决于 F30 的成功情况）受训者要求五年以上），(ii) 博士（4-5 年培训，3 年支持；3 名现任受训者，6 名）要求增加学员），(iii) 博士后研究（3 年培训和支持；3 名现任学员，5 名）要求额外的受训人员）和 (iv) 非公民博士受训人员（具有 DDS 学位）（3-5 年的培训，其中 3 多年的支持； 1 名现有学员 2 名要求额外学员）。我们将培训具有广泛知识的个人各种背景，从拥有学士/文学学士学位的人到完成博士学位和/或牙科学位的人住院医师培训。为了为我们的学者/学员提供坚实、共同的基础，我们开发了核心所有培训课程中所有学员所需的活动。我们正在引入几项新的程序功能：(i) 确保实现培训里程碑，(ii) 促进受训人员准备 F 和 K 奖，(iii) 更好整合我们的 DMD/PhD 的临床和研究培训，以促进向学术职业的过渡，以及 (iv) 教学和实验室管理的职业发展计划。康涅狄格大学健康中心拥有一支充满活力的团队各个研究领域的教师与整个学院的教师之间的合作非常成功牙科医学和医学系以及杰克逊基因组医学实验室。生物医学科学博士项目的研究生教师、活跃的新机构研究中心和临床项目提供当代实验室、转化和以患者为导向的研究机会，使多元化项目轨道的培训环境，允许灵活地满足学员的个人需求，并确保通过轨道取得成功。该机构制定了积极的实习生招募计划。有几个是针对代表性不足的少数族裔候选人。我们将继续提供量身定制的培训每位候选人通过座谈会、研讨会、课程、临床研究中心和合作研究这些活动既集成在单个轨道中，也集成在计划的所有轨道中。

项目成果

期刊论文数量（41）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Functionalized carbon nanotube reinforced scaffolds for bone regenerative engineering: fabrication, in vitro and in vivo evaluation.

用于骨再生工程的功能化碳纳米管增强支架：制造、体外和体内评估。

DOI：
发表时间：
2014-06
期刊：
影响因子：
0
作者：
Mikael, Paiyz E;Amini, Ami R;Basu, Joysurya;Josefina Arellano;Laurencin, Cato T;Sanders, Mary M;Barry Carter, C;Nukavarapu, Syam P
通讯作者：
Nukavarapu, Syam P

Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection.

低分子量 FGF2 异构体的消融会加速小鼠骨关节炎，而高分子量 FGF2 异构体的缺失则提供保护。