Utilizing All of Us data to examine the impact of COVID-19 on mental health among people living with HIV

利用 All of Us 数据研究 COVID-19 对 HIV 感染者心理健康的影响

• 批准号: 10657875
• 负责人: Xiaoming Li
• 金额: $ 10.73万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-16 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10657875
• 关键词: Acquired Immunodeficiency Syndrome; Address; Affect; Age-Years; Aging; All of Us Research Program; Anxiety; Anxiety Disorders; COVID-19; COVID-19 impact; COVID-19 outbreak; COVID-19 pandemic; COVID-19 pandemic effects; COVID-19 vaccination; Caring; Chronic Disease; Code; Collaborations; Complement; Complex; Data; Data Analyses; Data Science; Diabetes Mellitus; Diagnosis; Disadvantaged; Education; Electronic Health Record; Ethnic Origin; Financial Hardship; Fostering; Fright; Gender Identity; Goals; HIV; Health; Health Promotion; Health Services Accessibility; High Prevalence; Hypertension; Immune system; Impairment; Income; Individual; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Intervention; Investments; Knowledge; Loneliness; Low income; Lung diseases; Measures; Mental Health; Mental disorders; Mental health promotion; Mood Disorders; National Institute of Mental Health; Outcome; Participant; Patient Self-Report; Pattern; Personal Satisfaction; Personality Disorders; Persons; Population; Positioning Attribute; Prevention; Psyche structure; Public Health; Race; Reduce health disparities; Research; Research Priority; Risk Factors; SARS-CoV-2 infection; Sample Size; Schizophrenia; Series; Services; Sexual and Gender Minorities; Social Identification; Social Sciences; Social support; Stigmatization; Stress; Subgroup; Substance Use Disorder; Surveys; Symptoms; Testing; Translations; United States; United States National Institutes of Health; Vulnerable Populations; base; cloud based; cohort; comorbidity; design; disparity reduction; effective intervention; ethnic minority; experience; health assessment; health disparity; high risk; improved; large scale data; multiple datasets; negative affect; pandemic disease; parent grant; parent project; programs; protective factors; psychologic; psychosocial wellbeing; public health emergency; racial and ethnic; recruit; resilience; response; sexual identity; social disadvantage; social stigma; socioeconomic disadvantage; stress related disorder; theories; trend

Abstract In response to the NOSI (NOT-PM-22-002), we propose to expand the resilience conceptual framework in our parent grant (1R01MH127961-01A1, 12/2021-11/2026) to a different context (COVID-19) and a new population (people living with HIV [PLWH] in the United States). Further, we propose to explore if a resilience approach can be used to mitigate the negative impacts of COVID-19 on the mental health among PLWH. We will leverage multiple datasets from the All of Us program, including electronic health records (EHR), a series of COVID-19 Participant Experience (COPE) surveys, and other self-reported survey data. Integrating these data from about 12 thousand PLWH who participated in COPE, we will: 1) examine the trends and patterns of mental health outcomes (i.e., psychiatric disorder diagnoses via ICD-10 and mental health assessments via survey) among PLWH before and after the COVID-19 outbreak; and 2) identify protective factors at multiple socioecological levels including the individual level (e.g., resilience), interpersonal level (e.g., social support), and health institutional level (e.g., health service accessibility) that may mitigate the negative impacts of the COVID-19 pandemic on mental health outcomes among PLWH, especially the subgroups with socially disadvantaged status (low income and low education) and stigmatized identities (racial/ethnic minorities, sexual and gender minorities). Based on rich data from a large cohort of PLWH, the findings will advance our understanding of their mental health needs during the pandemic and mental health disparities of PLWH in the US and inform tailored health interventions to improve mental health outcomes among PLWH, especially those from disadvantaged subgroups. Our study goal is aligned with the Office of AIDS Research's and National Institute of Mental Health's research priorities in terms of social sciences studies and health disparities reduction. The proposed study will leverage existing NIH investment, capitalize on a rapid understanding of mental health needs among PLWH, stimulate additional collaborations with the All of Us program, and promote the translation of All of Us data to public health implications. The experience and preliminary data obtained from this supplement will position us for further efforts in utilizing All of Us data to improve mental and other health outcomes of PLWH in the US.

抽象的 为了响应 NOSI (NOT-PM-22-002)，我们建议扩展复原力概念框架 我们的家长拨款（1R01MH127961-01A1，12/2021-11/2026）到不同的背景（COVID-19）和新的 人口（美国艾滋病毒感染者 [PLWH]）。此外，我们建议探讨是否有弹性 方法可用于减轻 COVID-19 对 PLWH 心理健康的负面影响。我们 将利用 All of Us 计划的多个数据集，包括电子健康记录 (EHR)、一系列 COVID-19 参与者体验 (COPE) 调查以及其他自我报告的调查数据。整合这些 根据参与 COPE 的约 12,000 名 PLWH 的数据，我们将： 1) 研究以下趋势和模式： 心理健康结果（即通过 ICD-10 进行精神疾病诊断和通过 ICD-10 进行心理健康评估） 调查）在 COVID-19 爆发前后的 PLWH 中； 2）确定多个保护因素 社会生态层面，包括个人层面（例如复原力）、人际层面（例如社会支持）、 和卫生机构水平（例如，卫生服务的可及性）可以减轻负面影响 COVID-19 大流行对 PLWH 心理健康结果的影响，尤其是具有社交能力的亚群体 弱势地位（低收入和低教育）和污名化身份（种族/族裔少数群体、 性和性别少数）。基于大量 PLWH 的丰富数据，研究结果将推动我们的研究 了解他们在大流行期间的心理健康需求以及不同地区感染者的心理健康差异 美国并提供量身定制的健康干预措施，以改善 PLWH 的心理健康结果，特别是 来自弱势群体的人。我们的研究目标与艾滋病研究办公室和国家 心理健康研究所在社会科学研究和健康差异方面的研究重点 减少。拟议的研究将利用现有的 NIH 投资，利用对 PLWH 的心理健康需求，刺激与“我们所有人”计划的更多合作，以及 促进将“我们所有人”的数据转化为对公共卫生的影响。经验和初步数据 从本补充中获得的数据将使我们能够进一步努力利用我们所有人的数据来改善心理 以及美国艾滋病病毒感染者和艾滋病患者的其他健康结果。