HIV Vaccines, Immunoprophylaxis and Drugs

HIV 疫苗、免疫预防和药物

• 批准号: 10699245
• 负责人: TERRY L. SHEPPARD
• 金额: $ 2.13万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10699245
• 关键词: AIDS prevention; Abnormal Cell; Academia; Antibodies; Antigens; Area; Autoimmunity; B-Lymphocytes; Biology of HIV Transmission; COVID-19 prevention; Cellular biology; Clinical Trials; Collaborations; Colorado; Communicable Diseases; Dapivirine; Development; Disease; Educational workshop; Evaluation Studies; Foundations; Future; Government; HIV; HIV Infections; HIV vaccine; HIV-1; Immune; Industry; Infection; Investigation; Knowledge; Learning; Mediating; Mentors; Methodology; Methods; Outcome; Participant; Patients; Pharmaceutical Preparations; Phase; Prevention; Prevention approach; Prevention strategy; Research; Research Personnel; Resolution; Resources; Role; Science; Scientist; Thinking; Update; Vaccination; Vaccine Design; Vaccines; Work; cancer cell; clinical practice; design; effective therapy; efficacy study; immunoprophylaxis; improved; innovation; interest; meetings; method development; multidisciplinary; next generation; novel strategies; novel vaccines; pandemic disease; posters; pre-exposure prophylaxis; preclinical study; prevent; programs; prophylactic; prospective; rapid growth; response; symposium; treatment strategy; vaccination strategy; vaccine development; vaccine efficacy; vaccine platform; vaccine strategy

ABSTRACT Support is requested for a Keystone Symposia conference entitled HIV Vaccines, Immunoprophylaxis and Drugs, organized by Drs. Hanneke Schuitemaker, Steven Deeks and Dennis Burton. The conference will be held in Keystone, Colorado from June 6 - 10, 2023. Despite the availability of effective treatment and prevention strategies, the HIV pandemic continues, with approximately 1.7 million new infections annually. It is critical for there to be more effective prevention strategies. This Keystone Symposia conference will assemble experts on the biology of HIV transmission and emerging prevention methods, including vaccines and pre-exposure prophylaxis (PrEP), in order to discuss the current state-of-the-art in HIV prevention. Specific topics of discussion will include germline vaccination strategies and updates on the vaccine and PrEP efficacy studies. Additionally, the program will cover the challenges and opportunities of developing novel strategies in an era of increasingly effective prevention methods, particularly long-acting PrEP (cabotegravir) and the dapivirine ring, as well as next generation vaccine and PrEP approaches. The role that HIV prevention resources and advances have had on the COVID-19 prevention and HIV cure research agendas will also be discussed, with the hope that these three largely complementary areas of investigation will remain highly synergistic. Finally, this meeting is being held jointly with the Keystone Symposia conference, B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers. This pairing is ideal to discuss how B cell abnormalities contribute to HIV infection, especially in terms of the potential for antibody-based vaccine development. Participants from both conferences will have the opportunity to network through shared sessions, mealtimes, and evening poster sessions.

抽象的 请求支持题为“艾滋病毒疫苗、免疫预防和治疗”的 Keystone 研讨会 药物，由博士组织。汉内克·舒特梅克、史蒂文·迪克斯和丹尼斯·伯顿。会议将于 2023 年 6 月 6 日至 10 日在科罗拉多州基斯通举行。 尽管有有效的治疗和预防策略，艾滋病毒流行仍在继续， 每年约有 170 万新感染病例。更有效的预防至关重要 策略。这次 Keystone 研讨会将聚集艾滋病毒传播生物学和 新兴的预防方法，包括疫苗和暴露前预防（PrEP），以讨论 当前艾滋病毒预防的最先进水平。讨论的具体主题将包括种系疫苗接种 疫苗和 PrEP 功效研究的策略和更新。此外，该计划将涵盖 在预防日益有效的时代制定新战略的挑战和机遇 方法，特别是长效 PrEP（卡博替拉韦）和达匹韦林环，以及下一代 疫苗和 PrEP 方法。艾滋病毒预防资源和进展对艾滋病毒预防的作用 还将讨论 COVID-19 预防和 HIV 治疗研究议程，希望这三个 大部分互补的调查领域将保持高度协同作用。终于，这次会议召开了 与传染病背景下的 B 细胞生物学 Keystone Symposia 会议联合， 自身免疫和 B 细胞癌。这种配对非常适合讨论 B 细胞异常如何导致 HIV 感染，特别是在基于抗体的疫苗开发潜力方面。双方参与者 会议将有机会通过共享会议、用餐时间和晚间海报进行交流 会议。