Mental Health in Autistic Adults: An RDoC Approach

成人自闭症患者的心理健康：RDoC 方法

基本信息

批准号：
10698092
负责人：
BENJAMIN L HANDEN
金额：
$ 54.15万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-06 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10698092
关键词：
Adherence Adult Adverse event Age Aging Algorithms Anxiety Appointment Attention deficit hyperactivity disorder Biological Markers Brain Clinical Clinical Data Collaborations Communication Communities Consent Crisis Intervention Data Diagnosis Diagnostic Differential Diagnosis Dimensions Documentation Elderly Electronic Mail Enrollment Ensure Ethnic Origin Feeling suicidal Female Funding Funding Mechanisms Goals Grant Health Personnel Individual Intellectual functioning disability Lead Machine Learning Measures Mental Depression Mental Health Methods Minority Monitor Newsletter Participant Personality Disorders Persons Phenotype Probability Procedures Process Productivity Protocols documentation Psychiatric Diagnosis Race Recording of previous events Recruitment Activity Registries Reporting Research Research Domain Criteria Research Personnel Research Project Grants Resources Risk Rural Safety Schedule Services Structure Suicide Symptoms System Time Training Uncertainty United States National Institutes of Health Update Visit adult with autism spectrum disorder age related autism spectrum disorder autistic cognitive testing cohort ethnic identity experience human old age (65+)inclusion criteria indexing innovation marginalization marginalized population meetings novel participant retention phenotypic data predictive modeling programs racial identity recruit response satisfaction screening service intervention sex success suicidal suicidal behavior suicidal risk theories tool

项目摘要

Clinical Core Abstract The purpose of the Clinical Core is 1): To manage recruitment activities and consent and enroll a Pittsburgh ACE Cohort for participation in the three Projects. We will prioritize increased participation by individuals traditionally minoritized in ASD research (e.g., race/ethnicity, LGBTQIA+, females, and diagnosis of ASD in adulthood); 2): Administer, score, and enter data for ASD diagnostic assessments and administer all RFA- required and center-wide phenotypic measures; 3) Apply a novel posterior probability of diagnosis (PPOD) index to estimate the presence of psychiatric diagnoses and ASD; 4) Establish age-related variables for use across Projects, including a biomarker of brain age and documentation of age of ASD diagnosis; 5) Manage scheduling of participants for all Projects. 6) Support retention of participants and monitor progress through Projects; 7) Monitor risks related to suicidality and other adverse events, and 8) To collaborate with other Cores and Projects. The Core will enroll 200 autistic and 100 non-autistic 18- to 65-year-old adults (>50 in each group with a recent history of suicidal ideation or behaviors [SI/SB], defined as active SI/SB within the past four months). We anticipate needing to consent and assess approximately 100 additional individuals to account for those who do not meet inclusion criteria. Those meeting study inclusion criteria will be invited to participate in all three Projects. Our team has consistently met recruitment goals for numerous NIH-funded studies of autistic adults, we have active partnerships with several registries for autistic and non-autistic adults, and we will collaborate with the Dissemination and Partnership Core to enhance our inclusion of autistic adults from groups that have been marginalized. The Clinical Core organizes the extensive recruitment effort to assure the Projects meet their targeted enrollments and complete their proposed studies, while assuring all the data mandated by the ACE funding mechanism is collected. The centralization of these services in a Core combines the recruitment resources that would otherwise be distributed across Projects, thereby reducing the redundancy and inefficiency that would occur if each Project had to perform these efforts individually. Research-reliable Clinical Core staff will conduct ASD diagnostic and cognitive assessments using the tools outlined in the RFA; this also creates an efficient process and supports the collaboration of investigators new to autism in this ACE center. Finally, Clinical Core staff are highly experienced in the assessment of SI/SB and psychiatric diagnoses and will monitor for suicide-related risks.

临床核心摘要临床核心的目的是 1)：管理招募活动和同意并注册匹兹堡参与这三个项目的 ACE 队列。我们将优先考虑增加个人的参与传统上，自闭症谱系障碍 (ASD) 研究中的少数群体（例如，种族/族裔、LGBTQIA+、女性以及自闭症谱系障碍的诊断）成年）； 2)：管理、评分和输入 ASD 诊断评估数据，并管理所有 RFA- 所需的和中心范围内的表型测量； 3）应用新的后验诊断概率（PPOD）评估是否存在精神疾病和自闭症谱系障碍的指数； 4）建立与年龄相关的变量以供使用跨项目，包括大脑年龄的生物标志物和 ASD 诊断年龄的记录； 5）管理所有项目的参与者的安排。 6) 支持保留参与者并通过以下方式监控进度项目； 7) 监控与自杀和其他不良事件相关的风险，以及 8) 与其他人合作核心和项目。核心将招收 200 名自闭症患者和 100 名非自闭症 18 至 65 岁成年人（> 50 岁）每个近期有自杀意念或行为史的群体[SI/SB]，定义为活跃的SI/SB 过去四个月）。我们预计需要另外约 100 名个人同意并进行评估考虑那些不符合纳入标准的人。那些符合研究纳入标准的人将被邀请参与所有三个项目。我们的团队始终如一地实现了众多 NIH 资助的招募目标对成人自闭症的研究，我们与多个自闭症和非自闭症成人登记处建立了积极的合作伙伴关系，我们将与传播和伙伴关系核心合作，加强对自闭症成人的包容来自被边缘化的群体。临床核心组织了广泛的招募工作确保项目达到其招生目标并完成其拟议的研究，同时确保所有收集 ACE 资助机制规定的数据。这些服务集中在一个核心中结合了本来会分配到各个项目的招聘资源，从而减少了如果每个项目必须单独执行这些工作，就会出现冗余和低效率。研究可靠的临床核心人员将使用这些工具进行 ASD 诊断和认知评估 RFA 中概述；这也创建了一个高效的流程并支持新研究人员的合作 ACE 中心的自闭症患者。最后，临床核心人员在评估 SI/SB 和精神病学诊断并将监测与自杀相关的风险。