Children's Environmental Health Sciences Core Center

儿童环境健康科学核心中心

• 批准号: 7926628
• 负责人: DAVID Harold PETERING
• 金额: $ 1.5万
• 依托单位: UNIVERSITY OF WISCONSIN MILWAUKEE
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7926628
• 关键词: Address; Animal Model; Arts; Biological; Biometry; Cardiovascular Diseases; Child; Child health care; Childhood; Clinical; Communities; Community Health; Community Health Education; Community Outreach; Companions; Congenital Abnormality; Core Facility; Development; Disadvantaged; Disease; Education and Outreach; Endocrine disruption; Environmental Health; Fellowship Program; Fresh Water; Functional disorder; Genomics; Health; Health Sciences; Histology; Image; Infant; Institutes; Laboratories; Leadership; Life; Link; Marines; Microscopic; Modeling; Molecular Biology; National Children' s Study; Neonatal; Nurses; Outreach Research; Oxidative Stress; Patients; Pediatric Hospitals; Physicians; Pilot Projects; Plant Roots; Positioning Attribute; Public Health; Research; Research Infrastructure; Research Institute; Research Personnel; Research Support; Resources; Sampling; Science; Scientist; Services; Signal Transduction; Staging; System; Time; Universities; Vision; Wisconsin; Work; Zebrafish; base; career development; college; developmental disease; fetal; interest; medical schools; neurobehavioral; patient population; pediatric department; prevent; programs; reproductive; socioeconomics; teacher

DESCRIPTION (provided by applicant) The fetal, neonatal, and infant developmental periods represent times in which a daunting array of environmental challenges may compromise present and long-term health. The Children's Environmental Health Sciences Core Center addresses adverse health determinants in these early stages of life. The Center proposal is founded on the partnership between investigators formerly in the Marine and Freshwater Biomedical Sciences (MFBS) Center at the University of Wisconsin-Milwaukee and the Children's Research Institute (CRI) of Children's Hospital of Wisconsin. Former MFBS Center scientists focus on environmental determinants of reproductive and developmental diseases and disorders in aquatic models, principally the zebrafish, as well as mammalian systems. The CRI contributes clinical, translational and community health investigators who are highly knowledgeable about childhood diseases and focus on this patient population in both their research and practice. The primary objective or this proposal will be to attract and strongly support numerous teams of scientists positioned along the basic, translational, and clinical/public heath sciences continuum. Their work will move the Center to national prominence in research on childhood disease and its environmental contributors. The complementary objective will be to achieve leadership in the conversion of scientific understanding into effective community education aimed at preventing environmentally influenced childhood disease. The Center will support research on the environmental roots of neurobehavioral diseases, cardiovascular birth defects and reproductive dysfunctions in relation to signal transduction/endocrine disruption, oxidative stress, and genomic variability. Research and outreach linked to the National Children's Study Vanguard Program in Waukesha, WI and freshwater/Great Lakes and children's health serve as additional integrative foci for Center activities. Center resources for clinical and community research are gathered in the Integrative Health Sciences Facility Core with its concentrated assets for patient-based studies, deep support for community studies with critical links to the Community Outreach and Educational Core (COEC), and a wealth of biostatistics infrastructure support. A companion initiative in physician-scientist career development concentrates on a research-intensive pediatric environmental health fellowship program. The Aquatic Animal Models Facility Core supports a comprehensive zebrafish husbandry and experimentation facility, a unique neurobehavioral laboratory, and specialized molecular biology and genomics infrastructure. The Imaging and Histology Facility Core affords researchers using zebrafish and mammalian models, as well as clinical researchers, state-of-the art support for microscopic analysis, histological services, and storage of biological samples. The COEC will provide national leadership in rigorous outreach and education to teachers, nurses, and socioeconomically disadvantages communities. BACKGROUND The proposed Center would be formed by strengthening the existing partnership between the well-established Marine and Freshwater Biomedical Sciences Center at the University of Wisconsin-Milwaukee with the Pediatrics Department at the Medical College of Wisconsin. The partnership currently exists as the Children's Environmental Health Institute, which has been in place since 2006. This Institute has already attracted a number of basic scientists and clinician scientists through a shared interest in environmental health and the opportunity to conduct pilot projects. Based on the application, the University also has a newly formed College of Public Health. It is possible that resources offered to this College will indirectly strengthen the proposed Center. ESSENTIAL CHARACTERISTICS Strategic Vision and Impact on Environmental Health

描述（由申请人提供） 胎儿，新生儿和婴儿发育时期代表了一系列艰巨的环境挑战可能损害目前和长期健康的时代。 儿童的环境健康科学核心中心解决了生活早期阶段的不利健康决定因素。 该中心提案建立在以前是威斯康星大学 - 米尔沃基大学的海洋和淡水生物医学科学（MFBS）中心与威斯康星州儿童医院儿童研究所（CRI）之间的合作伙伴关系。 前MFBS中心科学家专注于水生模型（主要是斑马鱼以及哺乳动物系统）生殖和发育疾病和疾病的环境决定因素。 CRI贡献了临床，转化和社区健康调查人员，他们对儿童疾病非常了解，并专注于研究和实践中的患者人群。 主要目标或该建议将是吸引并强烈支持众多在基本，转化和临床/公共卫生科学连续体中定位的科学家团队。 他们的工作将把中心转移到有关儿童疾病及其环境贡献者研究方面的全国知名度。 补充目标将是在将科学理解转化为有效的社区教育方面取得领导才能，以防止环境影响受环境影响。 该中心将支持对神经行为疾病，心血管先天缺陷和生殖功能障碍的环境根源的研究，与信号转导/内分泌干扰，氧化应激和基因组变异性有关。 研究和外展与位于Waukesha，Wi和淡水/大湖和儿童健康的国家儿童学习先锋计划相关联，是中心活动的额外综合焦点。 临床和社区研究的中心资源收集在综合健康科学机构核心中，其集中资产用于患者研究，对社区研究的深刻支持与社区外展和教育核心（COEC）以及大量的生物统计学基础设施支持。 医师科学家职业发展的同伴倡议集中在研究密集的儿科环境健康奖学金计划上。 水生动物模型核心核心支持全面的斑马鱼饲养和实验设施，独特的神经行为实验室以及专门的分子生物学和基因组基础设施。 成像和组织学设施核心核心使用斑马鱼和哺乳动物模型，以及临床研究人员，对微观分析，组织学服务以及生物样品的存储的最先进的支持。 COEC将向教师，护士和社会经济上的劣势社区提供严格的外展和教育领域的国家领导。 背景 拟议的中心将通过加强威斯康星大学米尔沃基大学与威斯康星州医学院的儿科系的良好海洋和淡水生物医学科学中心之间的现有合作伙伴关系形成。 该合作伙伴关系目前是自2006年以来一直存在的儿童环境卫生研究所。该研究所已经通过对环境健康的共同兴趣和开展试点项目的机会吸引了许多基础科学家和临床科学家。 根据该应用程序，该大学还拥有新成立的公共卫生学院。提供给这所大学的资源可能会间接加强拟议中心。 基本特征 战略愿景和对环境健康的影响