Core B: Outreach, Ascertainment, and Data Collection

核心 B：外展、确定和数据收集

• 批准号: 10654532
• 负责人: Margaret A. Pericak-Vance
• 金额: $ 395.23万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10654532
• 关键词: Africa; African; African American population; Alzheimer' s Disease; American; Awareness; Biological; Biological Markers; Blood; Blood specimen; Clinical; Clinical Data; Collection; Country; DNA; Data; Data Collection; Dementia; Enrollment; Evaluation; Freezing; Future; Genetic Variation; Genetic study; Genotype; Goals; Hispanic; Individual; Infrastructure; Latinx; Lead; Measures; Metadata; Methods; Modification; Motivation; Neurocognitive; Nigeria; Participant; Patients; Plasma; Population; Procedures; Process; RNA; Research Personnel; Resources; Sampling; Site; Tube; Universities; Work; adjudication; biobank; cohort; forest; genome sequencing; human genomics; member; neurocognitive test; outreach; phenotypic data; rare variant; recruit; whole genome

PROJECT SUMMARY/ABSTRACT: CORE B (Outreach, Ascertainment and Data Collection Core) The overall goal of Core B is to provide the infrastructure and support for the ascertainment and collection of phenotypic data and biological samples on 4000 African Americans (AA), 4000 Hispanic/Latinx Americans (HL) and 5000 Africans (AF) from the US and Africa. The phenotypic data gathered by Core B will sent to Core E and used for adjudication and harmonization by Core C, while the blood, plasma, and RNA samples collected by Core B will be sent to the John P. Hussman Institute for Human Genomics (HIHG) at the University of Miami (UM), used for DNA genotyping for Projects 1 and 2 and future WGS studies in FUS 2.0 and biomarkers and expression studies (Core D). The work of Core B will provide the necessary materials for both common and rare variant analysis and discovery in ancestral populations in the imputation studies in Projects 1 and 2. Specific Aim 1 will recruit and ascertain AA and HL participants in four US and nine AF sites. The AF sites are in eight different countries, all members of the African Dementia Consortium (AfDC). The University of Ibadan, Nigeria, will be the primary coordinating site for the other AfDC sites. We will ascertain ~13,000 individuals/participants (6,500 cases and 6,500 controls) consisting of AA (n=4,000), HL (n=4,000) and AF (n=5,000). Specific Aim 2. We will collect clinical, neurocognitive testing, blood samples and metadata on AA (n=4,000), HL (n=4,000) and AF (n=5,000) participants. Tubes for DNA, RNA and plasma will be collected. This study will provide a resource for future studies in AD in AA, AF and HL patients.

项目概要/摘要：核心 B（外展、确定和数据收集核心） 核心 B 的总体目标是为确定和收集信息提供基础设施和支持。 4000 名非裔美国人 (AA)、4000 名西班牙裔/拉丁裔美国人 (HL) 的表型数据和生物样本 以及 5000 名来自美国和非洲的非洲人 (AF)。 Core B收集的表型数据将发送至Core E 并由 Core C 用于裁决和协调，同时收集血液、血浆和 RNA 样本 Core B 的成果将被送往迈阿密大学约翰·P·赫斯曼人类基因组学研究所 (HIHG) (UM)，用于项目 1 和 2 的 DNA 基因分型以及未来 FUS 2.0 和生物标志物中的 WGS 研究 表达研究（核心 D）。 Core B的工作将为常见和稀有的材料提供必要的材料 项目 1 和 2 的插补研究中祖先群体的变异分析和发现。 具体 目标 1 将在美国 4 个站点和 9 个 AF 站点招募并确定 AA 和 HL 参与者。 AF 部位位于八个 不同国家、非洲痴呆症联盟 (AfDC) 的所有成员。尼日利亚伊巴丹大学， 将成为其他 AfDC 站点的主要协调站点。我们将确定约 13,000 名个人/参与者 （6,500 例病例和 6,500 例对照）由 AA (n=4,000)、HL (n=4,000) 和 AF (n=5,000) 组成。具体目标2。 我们将收集 AA (n=4,000)、HL (n=4,000) 和 HL (n=4,000) 的临床、神经认知测试、血液样本和元数据 AF (n=5,000) 参与者。将收集 DNA、RNA 和血浆的试管。这项研究将提供资源 用于 AA、AF 和 HL 患者的 AD 未来研究。