2010 Glycolipid & Sphingolipid Biology Gordon Research Conference

2010糖脂

基本信息

批准号：
7800051
负责人：
Lina M OBEID
金额：
$ 2万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2010-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7800051
关键词：
1,2-diacylglycerol Achievement Advanced Development Aging Anaplastic astrocytoma Angiogenesis Inducing Agents Angioplasty Antibodies Apoptosis Apoptosis Promoter Apoptotic Area Arts Attention Bibliography Biochemical Biochemistry Bioinformatics Biological Biological Process Biology Catheters Cell Communication Cell Differentiation process Cell Membrane Structures Cell physiology Cell surface Cells Cellular biology Ceramides Cerebrosides Clinical Trials Colon Carcinoma Communicable Diseases Communities Complex Country Detergents Development Developmental Biology Diabetes Mellitus Diglycerides Discipline Disease Distal Environment Enzymes Etiology Event Feedback Fenretinide Figs - dietary Fostering Functional disorder Funding Future Galactosylceramides Gangliosides Generations Genetic Glycolipids Goals Growth Growth Factor Health Hemostatic function Human Hyperplasia Inflammation Inflammatory Inflammatory Bowel Diseases Inflammatory Response Information Dissemination Ionizing radiation Journals Lead Learning Link Lipids Malignant - descriptor Malignant Neoplasms Mass Spectrum Analysis Mediating Mediator of activation protein Membrane Membrane Lipids Membrane Microdomains Membrane Structure and Function Metabolic Metabolic Pathway Metabolism Methods Minority Modeling Molecular Mus Myelin Nature Neoplasm Metastasis Ovarian Tissue Participant Pathogenesis Pathology Pathway interactions Patients Peripheral Nervous System Diseases Pharmacology Physicians Platelet-Derived Growth Factor Play Proteins Publications Radiation Radiation therapy Ranvier&apos s Nodes Regulation Regulatory Pathway Relative (related person)Renaissance Research Research Personnel Resistance Role Safingol Scheme Science Scientist Series Severities Signal Pathway Signal Transduction Sphingolipids Sphingomyelinase Sphingosine Stimulus Structure Sulfoglycosphingolipids Techniques Therapeutic Therapeutic Agents Toxin Translational Research Tumor Necrosis Factor-alpha Tumor Promoters Tumor Suppressor Proteins Tumorigenicity Ursidae Family Woman Work acid sphingomyelinase analog angiogenesis base cancer cell cancer chemoprevention cancer therapy cell growth chemotherapeutic agent chemotherapy enzyme pathway field study insight lectures lipid metabolism metaplastic cell transformation next generation novel ovarian neoplasm polarized cell posters prognostic programs public health relevance receptor receptor function response restenosis sphingosine 1-phosphate sphingosine kinase symposium tissue culture trafficking tumor tumor progression

项目摘要

DESCRIPTION (provided by applicant): Partial support is requested for the Gordon Research Conference on Glycolipid and Sphingolipid Biology, to be held at the Ventura Beach Marriott, Ventura, CA from February 7 - 12, 2010 (and approximately this same date in 2012). The purpose of the conference is to encourage the transfer of ideas and information within the community of scientists who work at the cutting edge of glycolipid and sphingolipid research as well as to provide an environment where investigators from other scientific disciplines can learn about, and contribute to, this rapidly evolving field. Sphingolipids participate in many biological processes, including cell growth, differentiation and apoptosis, but only in the past decade have the molecular bases for these functions become clear (i.e., as modulators of membrane structure, cell-cell interactions, receptor functions, and signaling via ceramide, sphingosine 1-phosphate and others potent bioactive lipids). As an understanding of the roles of sphingolipids in disease etiology and treatment--most notably for cancer--has evolved, sphingolipid analogs such as safingol as well as anticancer chemotherapeutics that modify sphingolipid metabolism (such as fenretinide) have entered clinical trials, illustrating the strong partnership of basic and translational research in this field. Important aspects of this Gordon Conference are that it brings together scientists that work in different disciplines, such as basic biochemistry, genetics, developmental biology, cancer chemoprevention and chemotherapy and that it encourages participation of both senior investigators and junior investigators. As with previous Gordon Conferences in this series, there will be a significant percentage of participants from countries outside the U.S. as well as participation by women and minorities. Conferees will be encouraged to participate both in the formal lecture/discussion sessions, and less formally in poster presentations. The platform sessions will cover leading edge research in basic sphingolipid biology and biochemistry, and will include three sessions devoted to translational aspects of sphingolipid biology, specifically, sphingolipids in cancer, in infectious diseases and their roles as toxin receptors. The program will close with a future-oriented session on sphingolipidomics, focusing on the integration of sphingolipid metabolism and signaling, with a view to providing a comprehensive model of the functions of specific sphingolipids in regulating defined aspects of cell biology and and pathobiology.

说明（由申请人提供）：请求为戈登糖脂和鞘脂生物学研究会议提供部分支持，该会议将于 2010 年 2 月 7 日至 12 日（以及 2012 年大约同一日期）在加利福尼亚州文图拉的文图拉海滩万豪酒店举行。会议的目的是鼓励在糖脂和鞘脂研究前沿工作的科学家群体内交流思想和信息，并为其他科学学科的研究人员提供一个可以了解并做出贡献的环境。，这个快速发展的领域。鞘脂参与许多生物过程，包括细胞生长、分化和凋亡，但直到过去十年，这些功能的分子基础才变得清晰（即作为膜结构、细胞间相互作用、受体功能和信号传导的调节剂）神经酰胺、1-磷酸鞘氨醇和其他有效的生物活性脂质）。随着人们对鞘脂在疾病病因和治疗（尤其是癌症）中作用的认识不断发展，鞘脂类似物（如 safingol）以及改变鞘脂代谢的抗癌化疗药物（如芬维A胺）已进入临床试验，说明了该领域基础研究和转化研究的牢固伙伴关系。本次戈登会议的重要方面在于，它汇集了基础生物化学、遗传学、发育生物学、癌症化学预防和化疗等不同学科的科学家，并鼓励高级研究人员和初级研究人员参与。与本系列之前的戈登会议一样，将有很大比例的与会者来自美国以外的国家，以及妇女和少数族裔的参与。我们将鼓励与会者参加正式的讲座/讨论会议，以及非正式的海报展示。该平台会议将涵盖基础鞘脂生物学和生物化学的前沿研究，并将包括三场专门讨论鞘脂生物学转化方面的会议，特别是鞘脂在癌症、传染病中及其作为毒素受体的作用。该计划将以面向未来的鞘脂组学会议结束，重点关注鞘脂代谢和信号传导的整合，以期提供特定鞘脂在调节细胞生物学和病理学的特定方面的功能的综合模型。