A novel flat-panel detector for advanced on-board radiation therapy imaging

用于先进机载放射治疗成像的新型平板探测器

基本信息

批准号：
10652362
负责人：
Ross I. Berbeco
金额：
$ 58.13万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10652362
关键词：
3-Dimensional Acceleration American College of Radiology Clinic Clinical Dana-Farber Cancer Institute Data Development Devices Dose Electronics Future Goals Grant Head and neck structure High Performance Computing Hour Image Imaging Device Implant Infrastructure Knowledge Linear Accelerator Radiotherapy Systems Lung Magnetic Resonance Imaging Marketing Medical Metals Methods Monte Carlo Method Morphologic artifacts Parents Patients Penetration Performance Physics Procedures Productivity Prostate Publishing Radiation Oncology Radiation therapy Research Roentgen Rays Scheme System Technology Testing Time Translating United States National Institutes of Health Vertebral column clinical application clinical translation cost design detector experience image reconstruction imager improved innovation invention new technology novel reconstruction research clinical testing simulation soft tissue tool

项目摘要

Project Summary Despite recent technological advances, on-treatment imaging for radiotherapy procedures is still a significant challenge for tens of thousands of patients. On-board MRI or kV x-ray systems are either prohibitively expensive, provide incomplete information, or are incompatible with implanted metal devices. According to the American College of Radiology, megavoltage (MV) volumetric imaging has a clear advantage in terms of metal artifact reduction, direct dose calculation and real-time adaptive radiotherapy, but is challenged by low contrast and high imaging doses. We have demonstrated that this limitation can be overcome by a novel multi-layer imager to provide high-contrast, low-dose on-treatment MV imaging. This new technology will remove metal artifacts while retaining soft-tissue contrast and enable real-time adaptive radiotherapy. We have invented and validated a Monte Carlo-based tool that enables accurate image simulation in a fraction of the time required for conventional Monte Carlo simulation – enabling efficient imager optimization to be performed. Our preliminary data with a novel low-cost scintillator and efficient layering combinations has already demonstrated low- dose/high-quality MV-CBCT, rivaling conventional kV-CBCT, with added benefits of artifact reduction and Hounsfield unit accuracy. The Specific Aims of the current proposal will leverage our combined experience and previous results to produce an optimized imager suitable for widespread clinical use. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

项目概要尽管最近的技术取得了进步，放射治疗过程中的治疗成像仍然是一个重要的领域。对于数以万计的患者来说，机载 MRI 或 kV X 射线系统面临的挑战要么令人望而却步。昂贵，提供的信息不完整，或者与植入的金属设备不兼容。美国放射学院兆伏（MV）体积成像在金属方面具有明显优势伪影减少、直接剂量计算和实时自适应放疗，但受到低对比度的挑战我们已经证明，这种限制可以通过新型多层来克服。成像仪提供高对比度、低剂量的治疗中 MV 成像，这项新技术将去除金属。我们发明并实现了实时自适应放射治疗。验证了基于蒙特卡罗的工具，该工具可以在所需时间的一小部分内实现精确的图像模拟传统的蒙特卡罗模拟 - 能够执行我们的初步有效的成像器优化。具有新型低成本闪烁体和高效分层组合的数据已经证明了低剂量/高质量 MV-CBCT，可与传统 kV-CBCT 相媲美，并具有减少伪影和当前提案的具体目标将利用我们的综合经验和先前的结果可产生适合广泛临床使用的优化成像仪。 PHS 398/2590（修订版 06/09）页面延续格式页面

项目成果

期刊论文数量（24）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Leveraging multi-layer imager detector design to improve low-dose performance for megavoltage cone-beam computed tomography.

利用多层成像仪探测器设计来提高兆伏锥形束计算机断层扫描的低剂量性能。

DOI：
发表时间：
2018-01-30
期刊：
影响因子：
3.5
作者：
Hu, Yue;Rottmann, Joerg;Fueglistaller, Rony;Myronakis, Marios;Wang, Adam;Huber, Pascal;Shedlock, Daniel;Morf, Daniel;Baturin, Paul;Star;Berbeco, Ross
通讯作者：
Berbeco, Ross

A piecewise-focused high DQE detector for MV imaging.

用于 MV 成像的分段聚焦高 DQE 探测器。

DOI：
10.1118/1.4927786
发表时间：
2015-09-01
期刊：
Medical physics
影响因子：
3.8
作者：
J. Star;D. Shedlock;Dennis Swahn;D. Humber;Adam S. Wang;H. Hirsh;G. Zentai;D. Sawkey
通讯作者：
D. Sawkey

Low-dose megavoltage cone-beam computed tomography using a novel multi-layer imager (MLI).

使用新型多层成像仪 (MLI) 进行低剂量兆伏锥形束计算机断层扫描。

DOI：
发表时间：
2020-04
期刊：
影响因子：
3.8
作者：
Myronakis, Marios;Huber, Pascal;Lehmann, Mathias;Fueglistaller, Rony;Jacobson, Matthew;Hu, Yue;Baturin, Paul;Wang, Adam;Shi, Mengying;Harris, Thomas;Morf, Daniel;Berbeco, Ross
通讯作者：
Berbeco, Ross

Abbreviated on-treatment CBCT using roughness penalized mono-energization of kV-MV data and a multi-layer MV imager.

使用 kV-MV 数据的粗糙度惩罚单能量化和多层 MV 成像仪的简化治疗中 CBCT。

DOI：
发表时间：
2021
期刊：
影响因子：
3.5
作者：
Jacobson, Matthew W;Lehmann, Mathias;Huber, Pascal;Wang, Adam;Myronakis, Marios;Shi, Mengying;Ferguson, Dianne;Valencia;Hu, Yue;Baturin, Paul;Harris, Tom;Fueglistaller, Rony;Williams, Christopher;Morf, Daniel;Berbeco, Ro
通讯作者：
Berbeco, Ro

The markerless lung target tracking AAPM Grand Challenge (MATCH) results.

无标记肺目标跟踪 AAPM 大挑战 (MATCH) 结果。

DOI：
发表时间：
2022-02
期刊：
影响因子：
3.8
作者：
Mueller, Marco;Poulsen, Per;Hansen, Rune;Verbakel, Wilko;Berbeco, Ross;Ferguson, Dianne;Mori, Shinichiro;Ren, Lei;Roeske, John C;Wang, Lei;Zhang, Pengpeng;Keall, Paul
通讯作者：
Keall, Paul