Yoga, Aerobic and Stretching Exercise Effects on Neurocognitive Performance: A Randomized Controlled Trial

瑜伽、有氧运动和伸展运动对神经认知能力的影响：一项随机对照试验

基本信息

批准号：
10645168
负责人：
Neha Pravin Gothe
金额：
$ 5.75万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2023-08-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10645168
关键词：
Activities of Daily Living Adult Aerobic Aerobic Exercise Affect Age Age Years Age-associated memory impairment Aging Alternative Therapies Alzheimer&apos s Disease Alzheimer&apos s disease pathology Alzheimer&apos s disease risk Anxiety Area Attention Behavioral Biological Markers Blood Brain Brain imaging Brain-Derived Neurotrophic Factor Breathing Chronic Cognition Cognitive Collaborations Complementary Health Complementary Medicine Control Groups Creativeness Effectiveness Elderly Exercise Exhibits Functional Magnetic Resonance Imaging Future Health Health Care Costs Hippocampus Hour Hydrocortisone Impaired cognition Individual Interleukin-6 Intervention Investigation Link Low Back Pain Magnetic Resonance Imaging Maintenance Measures Mediating Memory Mental Depression Mind-Body Intervention Modality Nature Neurobiology Neurocognitive Neurons Neuropsychology Neurosciences Non-Insulin-Dependent Diabetes Mellitus Older Population Outcome Participant Performance Personal Satisfaction Persons Physical activity Physiological Population Prefrontal Cortex Prevalence Preventive Productivity Public Health Randomized Randomized, Controlled Trials Recording of previous events Research Research Personnel Role Serum Single-Blind Study Speed Stress Stretching Structure Testing Therapeutic Time Training Walking Yoga active control group age related arm behavior measurement brain health cardiorespiratory fitness cardiovascular fitness cognitive benefits cognitive function cognitive performance comorbidity comparative efficacy cost effective effectiveness evaluation executive function exercise intervention exercise program exercise training experience fitness fitness test follow-up group intervention improved indexing inflammatory marker interest middle age mind/body molecular marker neurocognitive test neuropathology pilot trial prevent psychologic public health relevance remediation skills

项目摘要

Abstract Yoga, a physical activity based mind-body therapy has become increasingly popular as a preventive and therapeutic practice, making it one of the therapies with the most rapid increase in prevalence. Practice of yoga combines physical activity, modulated breathing and meditative exercises that combine to provide the practitioner a holistic mind-body experience. The effectiveness of yoga has been examined for a number of health outcomes, including stress, anxiety, depression, management of chronic conditions such as lower back pain and type 2 diabetes. Fewer studies have examined the effects of yoga practice on brain health and cognitive function. Age related cognitive decline is well documented. With the increasing population of older adults in the US, there is a need to not only test popular forms of exercise such as yoga, but also compare their efficacy with modalities such as aerobic exercise that have proven neurocognitive benefits. This research is timely in that yoga is a gentle and modifiable form of exercise that can be easily adapted for practice by older adults who may exhibit comorbidities or chronic health conditions that keep them from walking or performing other forms of aerobic exercise. To our knowledge, this is the first randomized control trial examining and comparing the effects of yoga and aerobic exercise training on behavioral and neurobiological correlates of cognitive function. We propose to conduct a 6-month randomized controlled exercise trial among older adults to compare the efficacy of yoga with aerobic exercise on cognitive function, brain structure and function, cardiorespiratory fitness, functional fitness, and inflammatory and molecular markers. Using a single-blind, three arm randomized control trail, 168 older adults ages 55-79 will be assigned to either: a Hatha yoga group, an aerobic exercise group or an active stretching and strengthening control group. The groups will engage in hour-long group exercise sessions 3x/week. A comprehensive neurocognitive test battery, brain imaging, cardiovascular fitness test, and a blood draw will take place at baseline; end of the 6-month intervention, and at 12-month follow-up. The proposed pilot RCT will examine the relationship between yoga training and improved cognitive functioning as well as identify neurobiological correlates as potential mechanisms of action through which yoga training exerts its effect on cognitive function. The investigative team is interdisciplinary, highly productive and has a history of collaboration in conducting exercise interventions examining neurocognitive outcomes in older adults.

抽象的瑜伽是一种基于身体活动的身心疗法，作为一种预防和治疗方法已变得越来越流行。治疗实践，使其成为流行率增长最快的疗法之一。瑜伽练习结合身体活动、调节呼吸和冥想练习，提供实践整体的身心体验。瑜伽的有效性已被多项研究证实健康结果，包括压力、焦虑、抑郁、腰背部等慢性疾病的管理疼痛和 2 型糖尿病。很少有研究探讨瑜伽练习对大脑健康和健康的影响。认知功能。与年龄相关的认知能力下降是有据可查的。随着老年人口的不断增加对于美国成年人来说，不仅需要测试瑜伽等流行的运动形式，还需要进行比较它们与有氧运动等方式的功效已被证明对神经认知有益。这项研究瑜伽是一种及时的运动，它是一种温和且可修改的运动形式，可以很容易地适应老年人的练习可能患有合并症或慢性健康状况而无法行走或表演的成年人其他形式的有氧运动。据我们所知，这是第一个随机对照试验并比较瑜伽和有氧运动训练对行为和神经生物学的影响认知功能的相关性。我们建议在老年人中进行一项为期 6 个月的随机对照运动试验，以比较瑜伽结合有氧运动对认知功能、大脑结构与功能、心肺功能的功效健康、功能健康、炎症和分子标记。使用单盲、三臂随机对照试验中，168 名 55-79 岁的老年人将被分配到：哈他瑜伽组、有氧运动组或主动伸展和力量对照组。各小组将参与每周 3 次，时长一小时的团体锻炼。综合神经认知测试电池、脑成像、心血管健康测试，并在基线时进行抽血； 6 个月干预结束时， 12个月的随访。拟议的试点随机对照试验将研究瑜伽训练和认知改善之间的关系功能以及识别神经生物学相关因素作为潜在的作用机制瑜伽训练对认知功能发挥作用。调查团队是跨学科的、高效的，并且在开展调查方面有着合作的历史运动干预检查老年人的神经认知结果。