Sickle Cell Disease Functional Assessment Validation and Exercise Pilot Intervention

镰状细胞病功能评估验证和运动试点干预

基本信息

批准号：
10570743
负责人：
CHARITY IBILOLA OYEDEJI
金额：
$ 16.2万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10570743
关键词：
Activities of Daily Living Address Adult Aerobic Age Aging Assessment tool Cell Aging Cessation of life Clinic Visits Clinical Cognition Cognitive Coupled Data Dependence Development Development Plans Dimensions Early identification Educational Intervention Elderly Emergency department visit Enrollment Equilibrium Exercise Failure Fatigue Focus Groups Foundations Funding Future Geriatric Assessment Geriatrics Goals Health Hematology Hospital Departments Hospitalization Impaired cognition Impairment Individual Intervention K-Series Research Career Programs Knowledge Length of Stay Life Expectancy Longevity Measures Medical Medicine Mentors Mentorship Methods Necrosis Nutritional status Oncology Outcome Pain Pain intensity Pain interference Participant Patient Outcomes Assessments Patients Performance Persons Pharmaceutical Preparations Physical Function Physical Performance Physical assessment Pilot Projects Population Process Property Prospective cohort Psychometrics Psychosocial Assessment and Care Pulmonary Heart Disease Quality of life Randomized, Controlled Trials Regression Analysis Research Research Personnel Risk Factors Sensory Sickle Cell Sickle Cell Anemia Sleep Social support Stroke Surveys Testing Time Training Programs Universities Validation Validity and Reliability Visit Walking Work acceptability and feasibility age related aging population career career development cohort comorbidity design disability exercise intervention exercise program exercise training experience follow-up frailty functional decline functional disability functional improvement health assessment health care service utilization improved instrumental activity of daily living low socioeconomic status modifiable risk mortality outcome prediction physical conditioning premature prevent primary outcome professor programs psychologic secondary outcome skills social success therapy development tool virtual

项目摘要

1 PROJECT SUMMARY/ABSTRACT 2 Despite improvements in median life expectancy for sickle cell disease from 14 years in 1973 to 3 61 years in recent cohorts from academic centers, adults with sickle cell disease (SCD) 4 experience functional impairments. They develop deficits in physical, social, and cognitive 5 function due to both age-related changes and SCD complications, such as avascular necrosis, 6 strokes, cardiopulmonary disease, and sensory deficits. There are no validated assessment 7 tools or interventions to improve physical function in older adults with SCD. Failure to recognize 8 and manage vulnerabilities and functional decline can lead to disability and premature death. In 9 a pilot study we evaluated the feasibility if the Sickle Cell Disease Functional Assessment (SCD- 10 FA) and demonstrated that it was feasible, acceptable, and safe. In this study, we will evaluate 11 the validity and reliability of the SCD-FA in a prospective cohort of older adults with SCD (age ≥ 12 40 years) (Aim 1). We will evaluate the utility of the SCD-FA to predict number of days 13 hospitalized per year as the primary outcome, and change in physical performance, Sickle Cell 14 Day Hospital visits, emergency department visits, dependence in Activities of Daily Living, and 15 death as secondary outcomes. We will also determine risk factors for impaired physical 16 performance (Aim 2). The SCD-FA will provide a method for: 1) assessing vulnerabilities in 17 multiple health domains, 2) identifying targets for interventions, and 3) measuring change in 18 function. To address functional impairments, we will adapt and pilot a personalized exercise 19 training program in older adults (age ≥ 40 years) with SCD (Aim 3). The intervention will be an 20 8-week virtual program adapted from Gerofit, which is a supervised exercise and health 21 promotion program for older adults that includes exercises customized to each person’s heath 22 status and underlying functional deficits. The expected outcome is to have pilot data to design a 23 randomized control trial of a personalized exercise intervention for older adults with SCD. 24 Dr. Oyedeji is an Assistant Professor of Medicine in the Division of Hematology at Duke 25 University. Her career development plan includes developing skills in health assessment tool 26 development and developing and implementing interventions with guidance from experts in 27 psychometrics, intervention development, implementation, geriatrics, and sickle cell disease. 28 This research coupled with coursework, professional development activities, and her mentorship 29 team will provide the necessary experience to support her success as she works towards her 30 goal of becoming an independent investigator and leader in SCD and aging.

1 项目概要/摘要 2 尽管镰状细胞病患者的中位预期寿命从 1973 年的 14 岁提高到 3 学术中心近期队列中 61 年的镰状细胞病 (SCD) 成人患者 4 人出现身体、社交和认知功能障碍。 5 由于年龄相关的变化和 SCD 并发症（例如缺血性坏死）而导致的功能障碍 6 中风、心肺疾病和感觉缺陷没有经过验证的评估。改善患有 SCD 的老年人身体功能的 7 种工具或干预措施未能认识到。 8、管理脆弱性和功能衰退可能导致残疾和过早死亡。 9 我们评估了镰状细胞病功能评估 (SCD- 10 FA）并证明这是可行的、可接受的和安全的。在本研究中，我们将进行评估。 11 SCD-FA 在老年 SCD 患者前瞻性队列中的有效性和可靠性（年龄≥ 12 40 年）（目标 1）我们将评估 SCD-FA 预测天数的效用。每年有 13 人住院作为主要结局，以及身体机能的变化、镰状细胞 14 天医院就诊、急诊科就诊、日常生活活动依赖，以及 15 死亡作为次要结局，我们还将确定身体受损的危险因素。 16 性能（目标 2）。SCD-FA 将提供一种方法：1) 评估以下方面的漏洞。 17 个多个卫生领域，2) 确定干预目标，以及 3) 衡量变化 18 功能为了解决功能障碍，我们将调整并试点个性化锻炼。 19 患有 SCD 的老年人（年龄 ≥ 40 岁）的培训计划（目标 3）。 20 个为期 8 周的虚拟计划改编自 Gerofit，这是一个有监督的运动和健康项目 21 项针对老年人的促销计划，其中包括针对每个人的健康状况定制的锻炼 22 现状和潜在的功能缺陷预期结果是获得试点数据来设计一个 23 项针对患有 SCD 的老年人进行个性化运动干预的随机对照试验。 24 Oyedeji 博士是杜克大学血液学系医学助理教授 25 大学。她的职业发展计划包括培养健康评估工具的技能。 26 在专家的指导下制定、制定和实施干预措施 27 心理测量学、干预措施的制定、实施、老年病学和镰状细胞病。 28 这项研究加上课程作业、专业发展活动和她的指导 29 团队将提供必要的经验来支持她的成功，因为她朝着她的目标努力 30 目标是成为 SCD 和衰老领域的独立研究者和领导者。