Console Replacement and Upgrade of 9.4 Tesla Animal Instrument

9.4特斯拉动物仪控制台更换升级

• 批准号: 10414184
• 负责人: Wei Chen
• 金额: $ 132.8万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2024-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10414184
• 关键词: Animal Model; Animals; Biotechnology; Businesses; Cancer Grant Supplements (P30); Electronics; Engineering; Environment; Failure; Funding; Future; Grant; Left; Magnetic Resonance; Play; Positioning Attribute; Productivity; Protons; Publications; Recording of previous events; Research; Role; Services; Study models; System; Technology; Time; United States National Institutes of Health; Vendor; animal imaging; base; digital; imaging study; instrument; magnetic field; new technology; success

PROJECT SUMMARY/ABSTRACT The aim of this proposal is to replace the currently dysfunctional, unsupported, and discontinued Varian “console” (i.e., all RF, gradient, and digital electronics) on a unique 9.4 Tesla/31 cm bore Instrument dedicated to small to medium size animal model studies at the Center for Magnetic Resonance Research (CMRR). Due to Varian being taken over by Agilent Technologies in 2010 and the termination of the magnetic resonance businesses/service by Agilent Technologies three years later, this console is no longer supported. This 9.4 Tesla (T) NMR instrument is the world’s first horizontal bore scanner established for animal model studies at such a high magnetic field at a time when animal scanners operated at ≤ 4.7T. It has been the most productive instrument at CMRR, resulting in a large number of new technologies and important publications. Many animal imaging projects funded by eleven active NIH grants continue to rely on this instrument. A console replacement is urgently needed in order to avoid jeopardizing the success of these projects, and support future animal model based research in the highly productive environment of the CMRR. CMRR’s 9.4T/31 cm bore system has always played a crucial role in a large number of projects on animal models conducted within our past Biotechnology Research Center P41 and P30 grants. It is still slated for a critical role in our recently funded BTRC P41 EB02706, and in numerous present and past R01 and U01 grants from the NIH. However, the instrument, which we have been able to maintain until recently, is currently dysfunctional for proton imaging studies, and has also reached limits of its viability for other multinuclear applications. The termination of Varian as company and subsequent cessation of all MR support for Varian consoles and systems by Agilent Technologies left all Varian users, including us, in a very difficult and in the long-term an untenable position. As problems and failures emerged and accumulated on the instrument, several remained unresolved as Varian engineers were laid off, spare parts disappeared, and a commitment and the ability to fix these problems in Agilent and associated vendors vanished. Already many Varian users migrated to the consoles provided mainly by Bruker. Our 9.4 Tesla instrument has reached a critical point where a similar console replacement is now needed to continue the productivity that has marked the history of this animal model MR scanner. Therefore, US$1,328,035 funding is sought in this HEI grant for replacing the outdated 9.4T console, with an integrated and fully supported console from Bruker.

项目概要/摘要 该提案的目的是取代目前功能失调、不受支持且已停产的瓦里安 “控制台”（即所有射频、梯度和数字电子设备）位于独特的 9.4 特斯拉/31 厘米孔径仪器专用上 磁共振研究中心 (CMRR) 的中小型动物模型研究。 瓦里安于 2010 年被安捷伦科技收购，磁共振业务终止 三年后，安捷伦科技的业务/服务不再支持此控制台。 Tesla (T) NMR 仪器是世界上第一台用于动物模型研究的水平孔扫描仪 当动物扫描仪在 ≤ 4.7T 下运行时，如此高的磁场是最有生产力的。 CMRR 仪器，产生了大量新技术和许多动物的重要出版物。 由 11 项 NIH 有效拨款资助的成像项目继续依赖该仪器的控制台替代品。 迫切需要避免危及这些项目的成功，并支持未来的动物 在 CMRR 的高生产力环境中进行基于模型的研究。 CMRR的9.4T/31 cm口径系统一直在大量动物项目中发挥着至关重要的作用 我们过去的生物技术研究中心 P41 和 P30 资助中进行的模型仍计划获得资助。 在我们最近资助的 BTRC P41 EB02706 以及当前和过去的众多 R01 和 U01 资助中发挥着关键作用 然而，我们直到最近才能够维护该仪器，目前已停止使用。 对于质子成像研究来说功能失调，并且对于其他多核研究也达到了其可行性的极限 应用程序。 瓦里安公司终止，随后停止对瓦里安控制台的所有 MR 支持 安捷伦科技公司的系统让包括我们在内的所有瓦里安用户陷入了非常困难的长期困境 随着仪器上问题和故障的不断出现和积累，仍然存在一些问题和故障。 由于瓦里安工程师被解雇、备件消失以及修复的承诺和能力，这一问题尚未得到解决 安捷伦和相关供应商的这些问题已经消失，许多瓦里安用户已经迁移到了。 主要由布鲁克提供的控制台我们的 9.4 Tesla 仪器已经达到了类似的临界点。 现在需要更换控制台以继续保持这种动物历史上的生产力 型号 MR 扫描仪。 因此，本次 HEI 拨款寻求 1,328,035 美元资金，用于更换过时的 9.4T 控制台， 来自布鲁克的集成且完全受支持的控制台。