Prenatal and early-life black carbon exposure and childhood cardiometabolic health

产前和生命早期的黑碳暴露与儿童心脏代谢健康

基本信息

批准号：
10604098
负责人：
Chloe S Friedman
金额：
$ 3.71万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-01-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10604098
关键词：
6 year old 8 year old Adipose tissue Adult Age Air Air Pollutants Air Pollution Area Biological Biological Markers Birth Blood Body Composition Body Weight Body mass index Body measure procedure Brain Carbon Black Cardiometabolic Disease Cardiovascular Diseases Cardiovascular system Chemicals Child Childhood Chronic Disease Cohort Studies Colorado Complex Data Diabetes Mellitus Diameter Dietary Factors Enrollment Environment Environmental Epidemiology Environmental Exposure Environmental Impact Environmental Policy Environmental Pollutants Epidemiologic Methods Evaluation Exposure to Faculty Fatty acid glycerol esters Glucose Goals Growth Health Heterogeneity Homeostasis Institution Insulin Insulin Resistance International Knowledge Leptin Life Life Cycle Stages Life course epidemiology Link Lipids Literature Measurement Measures Medical Mentorship Metabolic Metabolic Diseases Methodology Methods Modeling Motor Vehicles Nature Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Overweight Participant Particulate Matter Phenotype Play Plethysmography Policies Policy Maker Postdoctoral Fellow Pregnancy Pregnant Women Prevalence Productivity Public Health Research Research Design Research Personnel Research Project Grants Resource Development Risk Risk Factors Role Scientist Source Statistical Models Techniques Toxic effect Training Universities Vehicle Emissions Work adipokines adiponectin adverse birth outcomes aged ambient air pollution biomarker panel cardiometabolic risk cardiometabolism cardiovascular disorder risk career career development cohort disorder risk doctoral student early childhood early life exposure environmental chemical epidemiology study ethnic diversity fasting glucose fine particles high risk improved indexing longitudinal analysis meter metropolitan modifiable risk mortality novel obesity in children obesity risk offspring pollutant postnatal predictive modeling prenatal research facility sedentary lifestyle skills spatiotemporal traffic-related air pollution waist circumference

项目摘要

PROJECT SUMMARY Child obesity is a major public health challenge. Exposure to environmental chemicals early in life may lead to increased risk for obesity and cardiometabolic health disruption in childhood. Black carbon is a traffic-related air pollutant that is associated with adverse cardiovascular outcomes and early mortality in adults. Very few previous epidemiologic studies have investigated black carbon exposure during early life and childhood obesity and growth outcomes. Accordingly, black carbon remains an understudied, yet widespread exposure with a biologically plausible link to disrupted cardiometabolic homeostasis. We will leverage existing data from the Healthy Start study, a pre-birth cohort of 1,410 pregnant women enrolled 2009-2014 and their offspring followed through age 8 years in the Denver-metropolitan area. Healthy Start has extensively phenotyped participants on biological and anthropometric measures of childhood cardiometabolic health, including precise body composition measures using state-of-the-art air displacement plethysmography, longitudinal measures of body mass index (BMI), and blood biomarkers of metabolic homeostasis including fasting glucose, insulin, lipids, and adipokines. The specific aims are: 1) to estimate associations between prenatal and childhood exposure to black carbon and indicators of adiposity at 4-6 years, 2) to estimate associations between prenatal and childhood exposure to black carbon and offspring cardiometabolic biomarkers at 4-6 years, and 3) to estimate longitudinal associations of prenatal and childhood exposure to black carbon with BMI growth trajectories from 2-8 years. We hypothesize that early-life exposure to black carbon will result in higher risk of adverse cardiometabolic outcomes in children. The results will advance understanding of the impact of black carbon, a specific traffic-related air pollutant, on childhood adiposity and cardiometabolic health. The findings will provide essential information to environmental policy makers responsible for regulating the public’s exposure to air pollution. The Applicant is a productive doctoral student at the University of Colorado- Anschutz Medical Campus, which offers state-of-the-art research facilities, internationally recognized faculty in obesity and diabetes, and a plethora of career development resources for doctoral students. The Applicant has assembled a strong mentorship team that comprises environmental scientists and lifecourse epidemiology experts and developed a comprehensive training plan to build specialized research and analytic skills, including 1) build knowledge in lifecourse epidemiology methods and study design, 2) gain skills in analytic approaches for complex correlated and spatially defined environmental exposures, and 3) develop methodologic expertise in statistical modeling techniques for longitudinal data. Through the completion of the proposed research and training plan, the Applicant will develop the skills necessary to successfully complete the proposed project and to continue on the path towards her career goal of becoming an independent researcher studying the impacts of environmental exposures on chronic diseases across the lifecourse.

项目摘要儿童肥胖是一个主要的公共卫生挑战。生命早期接触环境化学物质可能会导致童年时期肥胖和心脏代谢健康中断的风险增加。黑碳是与交通有关的与心血管不良结局和成年人早期死亡有关的空气污染物。很少先前的流行病学研究已经调查了早期和儿童肥胖期间黑碳的暴露并成长结果。彼此之间，黑碳仍然是一种理解的，但又广泛的暴露与心脏代谢稳态破坏的生物学上合理的联系。我们将利用现有数据健康的开始研究，1,410名孕妇于2009-2014及其后代组成的1,410名孕妇随后在丹佛分会地区到8岁。健康的开始已广泛表型儿童心脏代谢健康的生物学和人体测量的参与者，包括精确使用最先进的空气位移的身体组成测量，纵向测量体重指数（BMI）和代谢稳态的血液生物标志物，包括空腹葡萄糖，胰岛素，脂质和脂肪因子。具体目的是：1）估计产前与童年之间的关联在4 - 6年时暴露于黑碳和肥胖指标，2）估计产前之间的关联和儿童时期暴露于4 - 6年的黑碳和后代心脏代谢生物标志物，3）估计产前和儿童期暴露于BMI生长的纵向纵向关联 2 - 8年的轨迹。我们假设早期接触黑碳将导致更高的风险儿童的不良心脏代谢结果。结果将进一步了解黑色的影响碳是一种与交通相关的特定空气污染物，涉及儿童肥胖和心脏代谢健康。发现将向负责监管公众的环境政策制定者提供基本信息暴露于空气污染。申请人是科罗拉多大学 - 安苏兹大学的一名富有成效的博士生提供最先进的研究设施的医疗校园，肥胖学院公认和糖尿病，以及博士生的大量职业发展资源。申请人有组成了一个强大的心态团队，包括环境科学家和生命性流行病学专家并制定了一项全面的培训计划，以建立专业的研究和分析技能，包括1）在生命性流行病学方法和研究设计中建立知识，2）获得分析技能复杂相关且经常定义的环境暴露的方法，3）纵向数据的统计建模技术方面的方法论专业知识。通过完成拟议的研究和培训计划，申请人将发展成功完成所需的技能拟议的项目，并继续迈向成为独立的职业目标的道路研究人员研究环境暴露对整个生命的慢性疾病的影响。