Prenatal and early-life black carbon exposure and childhood cardiometabolic health

产前和生命早期的黑碳暴露与儿童心脏代谢健康

基本信息

批准号：
10604098
负责人：
Chloe S Friedman
金额：
$ 3.71万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-01-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10604098
关键词：
6 year old 8 year old Adipose tissue Adult Age Air Air Pollutants Air Pollution Area Biological Biological Markers Birth Blood Body Composition Body Weight Body mass index Body measure procedure Brain Carbon Black Cardiometabolic Disease Cardiovascular Diseases Cardiovascular system Chemicals Child Childhood Chronic Disease Cohort Studies Colorado Complex Data Diabetes Mellitus Diameter Dietary Factors Enrollment Environment Environmental Epidemiology Environmental Exposure Environmental Impact Environmental Policy Environmental Pollutants Epidemiologic Methods Evaluation Exposure to Faculty Fatty acid glycerol esters Glucose Goals Growth Health Heterogeneity Homeostasis Institution Insulin Insulin Resistance International Knowledge Leptin Life Life Cycle Stages Life course epidemiology Link Lipids Literature Measurement Measures Medical Mentorship Metabolic Metabolic Diseases Methodology Methods Modeling Motor Vehicles Nature Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Overweight Participant Particulate Matter Phenotype Play Plethysmography Policies Policy Maker Postdoctoral Fellow Pregnancy Pregnant Women Prevalence Productivity Public Health Research Research Design Research Personnel Research Project Grants Resource Development Risk Risk Factors Role Scientist Source Statistical Models Techniques Toxic effect Training Universities Vehicle Emissions Work adipokines adiponectin adverse birth outcomes aged ambient air pollution biomarker panel cardiometabolic risk cardiometabolism cardiovascular disorder risk career career development cohort disorder risk doctoral student early childhood early life exposure environmental chemical epidemiology study ethnic diversity fasting glucose fine particles high risk improved indexing longitudinal analysis meter metropolitan modifiable risk mortality novel obesity in children obesity risk offspring pollutant postnatal predictive modeling prenatal research facility sedentary lifestyle skills spatiotemporal traffic-related air pollution waist circumference

项目摘要

PROJECT SUMMARY Child obesity is a major public health challenge. Exposure to environmental chemicals early in life may lead to increased risk for obesity and cardiometabolic health disruption in childhood. Black carbon is a traffic-related air pollutant that is associated with adverse cardiovascular outcomes and early mortality in adults. Very few previous epidemiologic studies have investigated black carbon exposure during early life and childhood obesity and growth outcomes. Accordingly, black carbon remains an understudied, yet widespread exposure with a biologically plausible link to disrupted cardiometabolic homeostasis. We will leverage existing data from the Healthy Start study, a pre-birth cohort of 1,410 pregnant women enrolled 2009-2014 and their offspring followed through age 8 years in the Denver-metropolitan area. Healthy Start has extensively phenotyped participants on biological and anthropometric measures of childhood cardiometabolic health, including precise body composition measures using state-of-the-art air displacement plethysmography, longitudinal measures of body mass index (BMI), and blood biomarkers of metabolic homeostasis including fasting glucose, insulin, lipids, and adipokines. The specific aims are: 1) to estimate associations between prenatal and childhood exposure to black carbon and indicators of adiposity at 4-6 years, 2) to estimate associations between prenatal and childhood exposure to black carbon and offspring cardiometabolic biomarkers at 4-6 years, and 3) to estimate longitudinal associations of prenatal and childhood exposure to black carbon with BMI growth trajectories from 2-8 years. We hypothesize that early-life exposure to black carbon will result in higher risk of adverse cardiometabolic outcomes in children. The results will advance understanding of the impact of black carbon, a specific traffic-related air pollutant, on childhood adiposity and cardiometabolic health. The findings will provide essential information to environmental policy makers responsible for regulating the public’s exposure to air pollution. The Applicant is a productive doctoral student at the University of Colorado- Anschutz Medical Campus, which offers state-of-the-art research facilities, internationally recognized faculty in obesity and diabetes, and a plethora of career development resources for doctoral students. The Applicant has assembled a strong mentorship team that comprises environmental scientists and lifecourse epidemiology experts and developed a comprehensive training plan to build specialized research and analytic skills, including 1) build knowledge in lifecourse epidemiology methods and study design, 2) gain skills in analytic approaches for complex correlated and spatially defined environmental exposures, and 3) develop methodologic expertise in statistical modeling techniques for longitudinal data. Through the completion of the proposed research and training plan, the Applicant will develop the skills necessary to successfully complete the proposed project and to continue on the path towards her career goal of becoming an independent researcher studying the impacts of environmental exposures on chronic diseases across the lifecourse.

项目概要儿童肥胖是一个重大的公共卫生挑战，生命早期接触环境化学物质可能会导致肥胖。儿童肥胖和心脏代谢健康受损的风险增加黑碳与交通有关。与成人不良心血管结局和早期死亡相关的空气污染物很少。之前的流行病学研究调查了生命早期的黑碳暴露和儿童肥胖因此，黑碳仍然是一个未被充分研究但广泛存在的问题。与心脏代谢稳态紊乱之间的生物学上合理的联系我们将利用现有的数据。 Healthy Start 研究，2009-2014 年纳入 1,410 名孕妇及其后代的产前队列丹佛市区的健康起点在 8 岁时就已经出现了广泛的表型。参与者对儿童心脏代谢健康进行生物和人体测量测量，包括精确测量使用最先进的排气体积描记法测量身体成分，纵向测量体重指数 (BMI) 和代谢稳态的血液生物标志物，包括空腹血糖、胰岛素、脂质和脂肪因子的具体目标是：1）估计产前和儿童期之间的关联。 4-6 岁时接触黑碳和肥胖指标，2) 估计产前之间的关联以及儿童时期接触黑碳和后代 4-6 岁时心脏代谢生物标志物，以及 3) 估计产前和儿童时期接触黑碳与体重指数增长的纵向关联我们勇敢地承认，生命早期接触黑碳会导致更高的风险。研究结果将增进对黑人影响的了解。碳，一种与交通相关的特定空气污染物，对儿童肥胖和心脏代谢健康的影响。将为负责监管公众的环境政策制定者提供重要信息申请人是科罗拉多大学安舒茨分校的一名多产博士生。医学校区提供最先进的研究设施和国际公认的肥胖研究教师和糖尿病，以及为博士生提供的大量职业发展资源。组建一支由环境科学家和生命历程流行病学专家组成的强大指导团队专家并制定了全面的培训计划来培养专业研究和分析技能，包括 1) 积累生命历程流行病学方法和研究设计方面的知识，2) 获得分析技能复杂相关和空间定义的环境暴露的方法，以及3）开发通过完成纵向数据统计建模技术的方法学专业知识。拟议的研究和培训计划，申请人将培养成功完成所需的技能拟议的项目，并继续实现成为独立的职业目标研究人员研究环境暴露对整个生命周期慢性疾病的影响。