ABCD-USA Consortium: Data Analysis, Informatics and Resource Center

ABCD-美国联盟：数据分析、信息学和资源中心

• 批准号: 10391467
• 负责人: ANDERS M DALE
• 金额: $ 376.31万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10391467
• 关键词: 10 year old; Address; Adolescent; Affect; Alcohols; Athletic Injuries; Biological Assay; Brain; Brain imaging; Caffeine; Calibration; Childhood; Clinical assessments; Cognitive; Communities; Complex; Computer Analysis; Computer software; Data; Data Analyses; Data Analytics; Data Collection; Development; Diffusion Magnetic Resonance Imaging; Emotional; Enrollment; Ensure; Environment; Epidemiology; Functional Magnetic Resonance Imaging; Funding; Future; Genetic study; Guidelines; Human; Image; Individual; Informatics; Information Dissemination; Infrastructure; Link; Machine Learning; Magnetic Resonance Imaging; Marijuana; Measures; Mental Health; Mental disorders; Methods; Modality; Modeling; Monitor; National Institute of Mental Health; Neurocognition; Neurocognitive; Nicotine; Online Systems; Outcome; Parents; Participant; Physical activity; Procedures; Process; Protocols documentation; Quality Control; Questionnaires; Research; Research Personnel; Research Project Grants; Resources; Rest; Role; Sampling; Severities; Site; Sleep; Social Functioning; Specific qualifier value; Standardization; Statistical Data Interpretation; Surveys; Symptoms; Technology Assessment; Time; Triplet Multiple Birth; Twin Multiple Birth; Update; Youth; cognitive development; cognitive testing; cohesion; cohort; computer infrastructure; computerized; connectome; data archive; data dissemination; data exploration; data quality; data resource; data sharing; design; digital; experience; follow-up; gene interaction; handheld mobile device; health assessment; high standard; improved; informatics infrastructure; infrastructure development; mobile computing; multidimensional data; multimodality; neuroimaging; novel; open data; physical conditioning; recruit; retention rate; substance use; success; tool; tv watching; web portal

Project Summary/Abstract In its initial funding period, the ABCD consortium used a rigorous epidemiological approach to recruit a diverse sample of 11,878 9-10-year-olds through our 21 research sites, of which 2136 are twins or triplets. ABCD has created a comprehensive yet efficient protocol for participating youth and parents, using standardized and state-of-the-art methods for neuroimaging, biospecimens, and assessments of substance use, mental and physical health, neurocognition, culture, and environment, using a fully digital platform and making use of mobile technologies. We ensure cohesion and standardization by having employed a recruitment strategy designed by a professional survey company (experience with Monitoring the Future); standardized environmental, neurocognitive and mental health assessments, MRI assessments with all scanners using harmonized Human Connectome Project procedures, and computerized data collection with real-time quality control. Developmentally tailored assessments will have stable sensitivity and construct validity across the childhood and adolescent developmental period. They minimize participant burden, yet capture even subtle changes over time in substance use, mental health, neurocognition, development, and environment, and we employ novel state-of-the-art bioassays and passive data collection from mobile devices. A detailed retention plan builds on the experience and success of our investigators. This application describes the ABCD Data Analysis, Informatics and Resource Center (DAIRC), which will: maintain and update the harmonized MRI acquisition protocol, compatible with all major scanner platforms, taking advantage of recent technological advances in structural and functional MRI; perform rigorous quality control and quantitative calibration procedures to ensure accuracy and comparability of derived imaging measures across scanners and across time; implement advanced computational analysis workflows for all imaging data; implement reliable data entry, quality control, and monitoring tools for the substance use questionnaire, neurocognitive assessments, bioassay- derived measures, and mobile technologies assessment data; implement the state-of-the-art statistical analysis tools and procedures needed to integrate information across measures and modalities; continue development of infrastructure and procedures for public sharing of raw and derived data and associated tools and computational workflows; and enable interactive data exploration and analytics through a web-based Portal.

项目概要/摘要 在最初的资助期间，ABCD 联盟使用了严格的流行病学方法来 通过我们的 21 个研究中心招募 11,878 名 9-10 岁儿童的多样化样本，其中 2136 是双胞胎或三胞胎。 ABCD 创建了一个全面而有效的参与协议 青少年和家长，使用标准化和最先进的神经影像方法， 生物样本以及物质使用、心理和身体健康、神经认知的评估， 文化和环境，使用全数字平台并利用移动技术。 我们通过采用由以下人员设计的招聘策略来确保凝聚力和标准化 专业调查公司（有监测未来的经验）；标准化 环境、神经认知和心理健康评估、MRI 评估 使用统一的人类连接组项目程序和计算机化数据的扫描仪 具有实时质量控制的集合。针对发展量身定制的评估将具有稳定的 整个儿童和青少年发展时期的敏感性和结构有效性。他们 最大限度地减少参与者的负担，但随着时间的推移，捕捉在物质使用、心理方面的细微变化 健康、神经认知、发展和环境，我们采用新颖的最先进技术 生物测定和移动设备的被动数据收集。详细的保留计划建立在 我们研究人员的经验和成功。该应用程序描述了 ABCD 数据 分析、信息学和资源中心 (DAIRC)，该中心将： 维护和更新 统一的 MRI 采集协议，与所有主要扫描仪平台兼容， 利用结构和功能 MRI 的最新技术进步；执行严格 质量控制和定量校准程序，以确保准确性和可比性 跨扫描仪和跨时间的衍生成像测量；实施先进的计算 所有成像数据的分析工作流程；实施可靠的数据输入、质量控制和 物质使用调查问卷、神经认知评估、生物测定的监测工具 衍生措施和移动技术评估数据；实施最先进的 整合各种措施和信息所需的统计分析工具和程序 方式；继续开发基础设施和程序以供公众共享原始和 衍生数据和相关工具以及计算工作流程；并启用交互式数据 通过基于网络的门户进行探索和分析。