Maryland Prostate Cancer Case-Control Study

马里兰州前列腺癌病例对照研究

• 批准号: 7733058
• 负责人: STEFAN AMBS
• 金额: $ 44.85万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7733058
• 关键词: Academic Medical Centers; Address; African American; Age; American; Area; Baltimore; Blood; Cancer Patient; Case-Control Studies; Chronic; Cities; Collection; Contractor; Data; Databases; Diagnostic Neoplasm Staging; Dietary Factors; Eligibility Determination; Enrollment; Epidemiologic Studies; Ethnic Origin; European; Exposure to; Freezing; Frequencies; Future; Genetic; Genetic Variation; Goals; Hereditary Malignant Neoplasm; Individual; Inflammation; Joints; Lung; Malignant neoplasm of lung; Malignant neoplasm of prostate; Maryland; Medical center; Metastatic Prostate Cancer; Minor; Molecular; Molecular Epidemiology; Molecular Profiling; Motor Vehicles; Occupational; Participant; Patients; Pharmaceutical Preparations; Phase; Pilot Projects; Population; Procedures; Prostate; Protocols documentation; Questionnaires; Race; Rate; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Resources; Risk Factors; Sampling; Sexually Transmitted Diseases; Socioeconomic Status; Specimen; Study Subject; Surveys; Testing; Tissue Sample; Tobacco; Tobacco use; Translational Research; Tumor Biology; Tumor stage; Universities; Urine; Veterans Hospitals; Virus Diseases; Work; base; cancer gene expression; cancer health disparity; cancer risk; case control; design; ethnic difference; health disparity; male; men; tumor

The greater Baltimore, Maryland area has a large population of African-Americans and European-Americans, which makes this area most suitable to investigate differences in the exposure to prostate cancer risk factors among these two groups. We designed a new protocol that proposes molecular epidemiology and translational research and the collection of blood, urine, tissue samples, and survey data. Other epidemiological studies of prostate cancer have been established in recent years; however, only a few of these studies address the need for health disparity research and will have the opportunity to collect fresh-frozen tumor specimens from case subjects. Our study was implemented in two phases. The first phase, which started in April of 2005 constituted a pilot study to evaluate recruitment procedures. This phase was successful and the full study was initiated with minor changes to the protocol in April of 2006. Study participants will be African-American and European-American males who reside in Baltimore city and surrounding areas. The study will recruit 600 prostate cancer cases and 600 population-based controls. The cases are recruited at two Baltimore hospitals, the Veterans Affairs Medical Center and the University of Maryland Medical Center. Cases will have pathologically confirmed prostate cancer. The population-based controls are identified through the Maryland Department of Motor Vehicles database, and are frequency-matched by age and race to cases. The study involves the administration of two questionnaires and collection of blood and urine from all study subjects. Fresh-frozen tumor specimens will be obtained from cancer patients where available. The two questionnaires consist of a main questionnaire and a supplemental questionnaire. The questionnaires evaluate familial cancer history, tobacco use, medication use, occupational history, socioeconomic status, and risk factors for prostate cancer. The study is supported by an epidemiological infrastructure that has been developed by our resource contractor at the University of Maryland for a lung cancer case-control study. This lung cancer study is ongoing, and the controls that are recruited for the prostate cancer study are joint controls with the lung cancer study. Hence, population-based male controls recruited by our contractor have double eligibility for the concurrent lung and prostate cancer studies. To achieve an age and race matching of cases and controls in the prostate study, we will over-sample male controls in the lung study. The study protocol and the two questionnaires can be accessed at: http://www3.cancer.gov/intra/lhc/Ambs/Prostate_Cancer_Case_Control_Study_Protocol.pdf http://www3.cancer.gov/intra/lhc/Ambs/Lung_Prostate_Case_Control_Questionnaire.pdf http://www3.cancer.gov/intra/lhc/Ambs/Prostate_Cancer_Supplementary Questionnaire.pdf This study is aimed at identifying the differences in tumor biology and risk factor exposure that exist among African-American and European-American men. We will test the hypothesis that environmental and genetic factors contribute to the existing prostate cancer health disparity among African-Americans and European-Americans. We will also use molecular work to examine race/ethnic differences in tumor biology. Currently, we have recruited about 350 cases and 180 population-based controls and we have collected blood and urine from these individuals. Future recruitment rates are set at 120 cases and 120 controls per year. The participation rate of eligible subjects has been very good and 87% of the eligible case patients and 93% of the eligible population-based controls enrolled into the study. Importantly, we had the same participation rates for African-Americans and European-Americans. We also collected about 40 fresh-frozen tumors.

大巴尔的摩，马里兰州地区拥有大量的非裔美国人和欧洲裔美国人，这使该地区最适合调查这两组中前列腺癌危险因素的差异。我们设计了一种新方案，该方案提出了分子流行病学和转化研究，以及血液，尿液，组织样本和调查数据的收集。近年来已经建立了对前列腺癌的其他流行病学研究。但是，其中只有少数研究涉及对健康差异研究的需求，并将有机会从病例受试者那里收集新鲜冻结的肿瘤标本。我们的研究分为两个阶段。第一阶段始于2005年4月，构成了一项试点研究，以评估招聘程序。这一阶段是成功的，整个研究是在2006年4月开始对该方案进行了微小变化的。研究参与者将是居住在巴尔的摩市及周边地区的非裔美国人和欧洲男性。该研究将招募600例前列腺癌病例和600例基于人群的对照。这些案件是在巴尔的摩两家医院，退伍军人事务医疗中心和马里兰大学医学中心招募的。病例将有病理确认的前列腺癌。基于人群的控件是通过马里兰州汽车数据库确定的，并且按年龄和竞赛频率与案件进行了频率。该研究涉及对所有研究对象的两份问卷和血液和尿液的收集。将从可用的癌症患者那里获得新鲜冷冻的肿瘤标本。这两个问卷由主要问卷和补充问卷组成。问卷评估了家族性癌症史，烟草使用，用药，职业历史，社会经济状况以及前列腺癌的危险因素。这项研究得到了马里兰州的资源承包商开发的流行病学基础设施的支持，该基础设施进行了肺癌病例对照研究。 这项肺癌研究正在进行中，前列腺癌研究募集的对照是与肺癌研究的关节对照。因此，我们承包商招募的基于人群的男性对照组具有并发肺和前列腺癌研究的双重资格。为了实现前列腺研究中病例和对照的年龄和种族匹配，我们将在肺部研究中过度样本的男性对照。可以访问：http：//www3.cancer.gov/intra/lhc/ambs/prostate_cancer_case_control_study_study_protocol.pdf，可以访问研究协议和两个问卷http://www3.cancer.gov/intra/lhc/ambs/lung_prostate_case_control_questionnaire.pdf http://wwwww3.cancer.gov/intra/lhc/lhc/ambs/ambs/ambs/prostate_cancer_cancer_cancer_cancer_cancer_cancer_cancer_supledienlions非裔美国人和欧美男人中存在的风险因素暴露。我们将检验以下假设：环境和遗传因素有助于非裔美国人和欧洲裔美国人现有的前列腺癌健康差异。我们还将使用分子工作来检查肿瘤生物学的种族/种族差异。目前，我们已经招募了大约350例和180例基于人群的对照，我们从这些人那里收集了血液和尿液。未来的招聘率每年设定为120例和120个对照。合格受试者的参与率非常好，其中87％的符合条件的患者和93％的符合条件的基于人群的对照参加了这项研究。重要的是，我们对非裔美国人和欧洲人的参与率相同。我们还收集了约40个新鲜液体肿瘤。