A Research Reboot of Tuberculosis on the Keystone Symposia 50th Anniversary

纪念 Keystone 研讨会 50 周年之际重启结核病研究

• 批准号: 10391376
• 负责人: Thale Cross Jarvis
• 金额: $ 0.9万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-11-02 至 2022-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391376
• 关键词: Achievement; Anniversary; Antibiotics; Area; Attention; Biological Models; COVID-19; COVID-19 pandemic; Cause of Death; Collaborations; Colorado; Communicable Diseases; Communication; Disease; Educational workshop; Ensure; Epidemic; Experimental Models; Goals; Growth; HIV; Infectious Agent; Interdisciplinary Communication; Knowledge; Lead; Measures; Methodology; New York City; Outcome; Pathogenesis; Pathway interactions; Public Health; Regimen; Research; Research Personnel; Scourge; Technology; Tuberculosis; Vaccines; Viral; clinical practice; co-infection; design; experience; improved; innovation; interdisciplinary collaboration; lectures; mortality; next generation; pandemic coronavirus; pandemic disease; pathogen; posters; programs; symposium; urban area; vaccine trial

ABSTRACT Support is requested for a Keystone Symposia conference entitled A Research Reboot of Tuberculosis on the Keystone Symposia 50th Anniversary, organized by Drs. Joseph Keane, Shabaana A. Khader, Thomas J. Scriba and Alan Sher. The conference will be held in Breckenridge, Colorado from January 23-26, 2022. Tuberculosis (TB) is an ancient scourge of mankind that still to this day remains a leading cause of death by a single infectious agent only surpassed in its global mortality by the current COVID-19 coronavirus pandemic. Nevertheless, with the advent of effective antibiotics and improved public health measures, in the middle of the 20th century, TB had substantially declined and was thought by many to be destined for eradication. By 1972, the year of the founding of the Keystone Symposia, this conclusion was quashed by expanding caseloads in New York City and other urban areas and later by the devastating impact of HIV-coinfection. This major disease re-emergence stimulated a new era of intense research aimed at conquering TB. This symposium will showcase the outstanding breakthroughs of TB researchers over the last 50 years, while highlighting current advances in the field. Special attention will be given to the results of the latest promising vaccine trials, as well the discovery and implementation of improved antibiotic regimens. This program will also emphasize the exciting advances in our basic understanding of the host-pathogen interaction, and in particular in the area of immunometabolism, that are leading to the identification of new host-directed treatment targets. Keynote lectures will overview the major achievements, while exploring the current state of global tuberculosis, as well as the impact of viral pandemics on tuberculosis research and control. Taken together, the program will propel the field forward toward achievement of our ultimate goal of TB eradication.

抽象的 请求支持题为“结核病研究重启”的 Keystone 研讨会 Keystone 研讨会 50 周年，由 Drs 组织。约瑟夫·基恩、沙巴娜·A·哈德尔、托马斯·J. 斯克里巴和艾伦·谢尔。会议将于2022年1月23日至26日在科罗拉多州布雷肯里奇举行。 结核病 (TB) 是一种古老的人类祸害，至今仍是人类死亡的主要原因。 单一传染源的全球死亡率仅被当前的 COVID-19 冠状病毒大流行所超越。 然而，随着有效抗生素的出现和公共卫生措施的改善， 20世纪，结核病大幅减少，许多人认为结核病注定会被根除。到 1972 年， 在 Keystone 研讨会成立的那一年，这一结论因案件数量的增加而被推翻。 纽约市和其他城市地区后来又受到艾滋病毒合并感染的毁灭性影响。这个专业 疾病的重新出现激发了旨在征服结核病的深入研究的新时代。本次研讨会将 展示过去 50 年来结核病研究人员的杰出突破，同时强调当前 该领域的进展。还将特别关注最新有希望的疫苗试验的结果 改进抗生素治疗方案的发现和实施。该计划还将强调 我们对宿主与病原体相互作用的基本理解取得了令人兴奋的进展，特别是在 免疫代谢，这导致新的针对宿主的治疗靶点的识别。基调 讲座将概述主要成就，同时探讨全球结核病的现状，以及 病毒大流行对结核病研究和控制的影响。总而言之，该计划将推动 朝着实现消灭结核病的最终目标迈进。