Measurement and Analysis of Aging, Cognition and Alzheimer's Disease and Related Dementia (ADRD) Risk Factors at Midlife in the Kenya Life Panel Survey (KLPS)

肯尼亚生活追踪调查 (KLPS) 中年衰老、认知和阿尔茨海默病及相关痴呆 (ADRD) 危险因素的测量和分析

• 批准号: 10618926
• 负责人: EDWARD ANDREW MIGUEL
• 金额: $ 144.22万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-15 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10618926
• 关键词: Adult; Affect; Africa South of the Sahara; African; Aftercare; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Attitude; Back; Biological Assay; Biological Markers; Blood; Characteristics; Child; Child Health; Childhood; Cognition; Cognitive; Data; Data Collection; Data Set; Dementia; Diabetes Mellitus; Diagnosis; Disadvantaged; Discipline; Dryness; Education; Elderly; Freezing; Funding; Future; Genetic Markers; Hand Strength; Health; Health Status; Health behavior; Hypertension; Impaired cognition; Individual; Inflammation; Intervention; Interview; Kenya; Language; Life; Life Cycle Stages; Link; Literature; Living Standards; Marketing; Measurement; Measures; Memory; Mental Depression; Mental Health; National Institute of Child Health and Human Development; Nutritional; Obesity; Occupational; Occupations; Outcome; Participant; Pathway interactions; Patient Self-Report; Pharmaceutical Preparations; Phenotype; Physical activity; Predictive Factor; Prevalence; Primary Schools; Protocols documentation; Random Allocation; Randomized; Recording of previous events; Research Personnel; Respondent; Risk Factors; Sampling; Schools; Smoking; Social Interaction; Socioeconomic Status; Spottings; Stress; Surveys; Testing; Time; Uncertainty; Validation; Variant; Visuospatial; Work; achievement test; behavioral outcome; cognitive performance; cognitive testing; cohort; dementia risk; design; diabetes control; disability; drinking; economic outcome; emerging adult; executive function; field survey; health data; human old age (65+); instrumental activity of daily living; mental state; middle age; migration; novel; physical conditioning; programs; public health intervention; sleep pattern; social; social contact; sociodemographics; study population; young adult; Adult; Affect; Africa South of the Sahara; African; Aftercare; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Attitude; Back; Biological Assay; Biological Markers; Blood; Characteristics; Child; Child Health; Childhood; Cognition; Cognitive; Data; Data Collection; Data Set; Dementia; Diabetes Mellitus; Diagnosis; Disadvantaged; Discipline; Dryness; Education; Elderly; Freezing; Funding; Future; Genetic Markers; Hand Strength; Health; Health Status; Health behavior; Hypertension; Impaired cognition; Individual; Inflammation; Intervention; Interview; Kenya; Language; Life; Life Cycle Stages; Link; Literature; Living Standards; Marketing; Measurement; Measures; Memory; Mental Depression; Mental Health; National Institute of Child Health and Human Development; Nutritional; Obesity; Occupational; Occupations; Outcome; Participant; Pathway interactions; Patient Self-Report; Pharmaceutical Preparations; Phenotype; Physical activity; Predictive Factor; Prevalence; Primary Schools; Protocols documentation; Random Allocation; Randomized; Recording of previous events; Research Personnel; Respondent; Risk Factors; Sampling; Schools; Smoking; Social Interaction; Socioeconomic Status; Spottings; Stress; Surveys; Testing; Time; Uncertainty; Validation; Variant; Visuospatial; Work; achievement test; behavioral outcome; cognitive performance; cognitive testing; cohort; dementia risk; design; diabetes control; disability; drinking; economic outcome; emerging adult; executive function; field survey; health data; human old age (65+); instrumental activity of daily living; mental state; middle age; migration; novel; physical conditioning; programs; public health intervention; sleep pattern; social; social contact; sociodemographics; study population; young adult

Project Summary/Abstract Alzheimer’s disease is severely under-studied in Sub-Saharan Africa: the few existing estimates suggest that prevalence is currently low but changing risk factors predict that it could double in the next 20 years. We propose to study risk factors for Alzheimer’s disease and related dementias (AD/ADRD) in the Kenya Life Panel Survey (KLPS), a unique, richly phenotyped cohort of Kenyan adults who have been followed since childhood, and who were participants in a randomized child health intervention (school-based deworming). The existing dataset contains information on health, cognition, educational, demographic, social attitudes, and labor market outcomes for over 6,500 Kenyans first surveyed in 1998 (at ages 8-15) through 2021 (ages 31-39). KLPS thus provides an unusual opportunity to study cognition, and the determinants of AD/ADRD and related risk factors, over the life course, with direct measurement during childhood, young adulthood, and midlife. This project proposes an additional field interview in the KLPS Round 5 Aging Module (KLPS-5A) to collect detailed “midlife baseline” cognition and aging-related health data, as well as information on AD/ADRD risk factors, among participants, who will be 35 to 43 years old at the time of survey. One novel aspect is the ability to link these midlife measures to rich existing longitudinal data from childhood and early adulthood, including cognitive assessments (achievement and cognitive test scores), as well as educational outcomes, health status and behaviors, and economic outcomes (e.g., earnings, migration, occupational complexity) collected contemporaneously rather than via recall in later life. By combining state-of-the-art cognitive measures at this new midlife timepoint with the extensive cognitive measures and exposures already collected, we hope to establish KLPS as the premier African study of life-course dementia determinants. There are very few surveys globally that include such detailed data from childhood to old age, and these data would open up multiple avenues for investigating dementias tied to life-course disadvantages. We will make all data publicly available to researchers across disciplines. Another notable feature is the ability to utilize experimental variation from a randomized child health intervention that has been documented to meaningfully affect adult living standards and several risk factors for dementia, to better understand pathways over the life course and the scope for public health interventions to reduce AD/ADRD risk. The Primary School Deworming Program provided deworming medication to randomly-selected schools starting in 1998 in a region with high worm prevalence (>90%): 10 to 20 years after treatment, the intervention had positive effects on self-reported health, educational attainment; adult living standards; urban residential status, and occupation in the non-agricultural sector. This setting offers an unusual opportunity to experimentally test the extent to which an effective child health intervention can affect AD/ADRD risks and midlife health and cognition, as much of the associational literature suggests.

项目摘要/摘要 在撒哈拉以南非洲，阿尔茨海默氏病严重研究了：少数现有的估计表明 患病率当前很低，但变化的风险因素预测，它在未来20年内可能会增加一倍。我们 肯尼亚生活中研究阿尔茨海默氏病和相关痴呆症（AD/ADRD）危险因素的提议 小组调查（KLP），这是一个独特，表现丰富的肯尼亚成年人队列，此后一直受到关注 童年，并且是随机儿童健康干预措施（基于学校的驱虫）的参与者。这 现有数据集包含有关健康，认知，教育，人口统计，社交吸引力和劳动的信息 1998年（8-15岁）至2021年（31-39岁）首次调查了6,500多名肯尼亚人的市场成果。 因此，KLP为研究认知提供了异常的机会，AD/ADRD及其相关的决定者 危险因素，在生活过程中，在儿童时期，成年和中年时期进行直接测量。 该项目建议在KLPS第5轮老化模块（KLPS-5A）中进行其他现场访谈 详细的“中年基线”认知和与衰老有关的健康数据以及有关AD/ADRD风险的信息 在调查时，参与者中的因素将35至43岁。一个新颖的方面是能力 将这些中年措施与童年和成年初期的现有纵向数据联系起来，包括 认知评估（成就和认知考试成绩）以及教育成果，健康 地位和行为以及经济成果（例如收入，移民，职业复杂性）收集了 同时而不是通过以后的回忆。通过结合最先进的认知措施 新的中年时间点具有已经收集的广泛认知测量和暴露，我们希望 将KLP确立为非洲主要研究痴呆症决定者的主要研究。调查很少 全球包括从童年到老年的详细数据，这些数据将打开多个 调查与生命过程灾难相关的痴呆症的途径。我们将使所有数据公开可用 给跨学科的研究人员。 另一个值得注意的特征是能够利用随机儿童健康的实验变化 已记录的干预措施有意义地影响成人生活水平和几个风险因素 痴呆症，以更好地了解生活过程中的途径和公共卫生干预措施的范围 降低广告/ADRD风险。小学驱虫计划为 从1998年开始在蠕虫患病率高的地区（> 90％）开始的随机选择的学校：10至20年后 治疗，干预对自我报告的健康，教育成就产生积极影响；成人生活 标准；城市居民的地位和非农业部门的职业。此设置提供了不寻常的 实验测试有效的儿童健康干预可能影响AD/ADRD的机会 风险和中年健康和认知，正如许多协会文献所表明的那样。