North Carolina Diabetes Research Center

北卡罗来纳州糖尿病研究中心

基本信息

批准号：
10382306
负责人：
DONALD A. MCCLAIN
金额：
$ 119.76万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-07 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10382306
关键词：
Address Agriculture Automobile Driving Caring Clinical Research Clinical Sciences Clinical and Translational Science Awards Cluster Analysis Collaborations Communities Diabetes Mellitus Doctor of Philosophy Fostering Funding Future Genomics Goals Grant Hospitals Infrastructure Institution Interdisciplinary Study International Leadership Link Methods Modeling National Institute of Diabetes and Digestive and Kidney Diseases North Carolina Pathway Analysis Patients Persons Phenotype Productivity Proteomics Recording of previous events Research Research Design Research Infrastructure Research Personnel Research Support Resource Sharing Resources Scientist Services Site Solid Techniques Training Training Programs Training and Education Translating Translations United States National Institutes of Health Universities Work base career clinical care cohesion diabetes risk diabetic patient epigenomics forest innovation inter-institutional interest medical schools member metabolomics metabolomics resource novel outreach programs recruit symposium translational approach translational pipeline translational study

项目摘要

PROJECT SUMMARY/ABSTRACT – CENTER OVERVIEW This proposal seeks to create and support an interactive regional diabetes research community (184 members) across four premiere research institutions in North Carolina, who currently garner over $70 million annually for support of their diabetes research: Duke University (Duke) The University of North Carolina at Chapel Hill (UNC), Wake Forest School of Medicine (WF), and North Carolina A&T (NC A&T). The North Carolina Diabetes Research Center (NCDRC) will support Research Cores that represent unique strengths at each institution. These Cores will support studies of the current Research Base at each respective institution, but will also be made available to the other NCDRC institutions, where their use has been hampered by less easy access. An expanded Pilot and Feasibility Program will encourage use of these now regional Cores, bring to the field new investigators and young scientists, and draw those not previously working in the field. We will leverage the existing infrastructure at each institution’s NIH Clinical and Translational Science Award (CTSA) site, to guide investigators to other resources that enhance their scientific productivity and efficiency. The goal of this new Center is to create connectivity in the diabetes research community, thereby fostering new advances in basic and translational diabetes research. We will take advantage of the substantial pre-existing resources and capabilities at each institution, and connect investigators to resources unique to each campus, to maximize the ability of member investigators – whether new investigators or scientists new to diabetes research – to answer important questions across the spectrum of translational approaches. There is a history of collaboration in diabetes research among the four institutions. Most importantly for this application, however, are the unique strengths that can be shared among our campuses, and the enormous potential for a large and cohesive community of investigators to advance diabetes research further. Regional Core Resources to be directly supported by the NCDRC will include a Genomics and Proteomics Core, and a world-renowned Metabolomics Core, including not only a range of state-of-the-art analyses but equally importantly, interpretive services that are often a bottleneck for such resources. Expertise in the Advanced Clinical Sciences Methods Core will be focused on driving translation of discovery to clinical care of diabetes, emphasizing state-of-the-art methods. Each Core will offer specialized Research Navigators to guide diabetes-focused investigators. Finally, an Enrichment Program will plan and sponsor an annual symposium, reaching out to investigators whose work and techniques could inform diabetes research. Fellows supported on T32 or T35 training programs at Duke, UNC, and WF, whose work is evolving in a diabetes-relevant direction, will be a special focus for outreach.

项目概要/摘要 – 中心概述该提案旨在创建和支持一个互动的区域糖尿病研究社区（184 名成员）北卡罗来纳州的四个一流研究机构目前每年吸引超过 7000 万美元的资金支持他们的糖尿病研究：杜克大学（Duke）、北卡罗来纳大学教堂山分校（UNC）、维克森林医学院 (WF) 和北卡罗来纳州 A&T (NC A&T)。研究中心 (NCDRC) 将支持代表每个机构独特优势的研究核心。这些核心将支持每个机构当前研究基地的研究，但也将向其他 NCDRC 机构提供，但由于访问不太方便，这些机构的使用受到阻碍。扩大的试点和可行性计划将鼓励使用这些现在的区域核心，为该领域带来新的研究人员和年轻科学家，并吸引那些以前没有在该领域工作过的人。每个机构的 NIH 临床和转化科学奖 (CTSA) 站点的现有基础设施，以指导研究人员可以利用其他资源来提高他们的科学生产力和效率。该中心旨在建立糖尿病研究界的联系，从而促进基础研究的新进展我们将利用大量现有资源和转化糖尿病研究。每个机构的能力，并将研究人员与每个校园特有的资源联系起来，以最大限度地提高成员研究人员（无论是新研究人员还是刚接触糖尿病研究的科学家）回答问题的能力跨转化方法领域的重要问题有合作的历史。然而，这四个机构中最重要的糖尿病研究是独一无二的。可以在我们的校园之间共享的优势，以及建立一个庞大而有凝聚力的大学的巨大潜力研究人员社区进一步推进糖尿病研究。 NCDRC 支持的项目将包括基因组学和蛋白质组学核心以及世界著名的代谢组学核心，不仅包括一系列最先进的分析，还包括同样重要的解释服务高级临床科学方法核心的专业知识往往会成为此类资源的瓶颈。专注于推动糖尿病的发现转化为临床护理，强调最先进的方法。每个核心都将提供专门的研究导航器来指导以糖尿病为重点的研究人员。丰富计划将策划并赞助年度研讨会，接触其工作和技术可以为糖尿病研究提供信息，支持北卡罗来纳大学杜克大学 T32 或 T35 培训项目， WF 的工作正在向糖尿病相关方向发展，因此将成为外展工作的特别重点。