Wake Forest Clinical and Translational Science Award

维克森林临床和转化科学奖

基本信息

批准号：
10404193
负责人：
DONALD A. MCCLAIN
金额：
$ 6.63万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-13 至 2022-02-24
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10404193
关键词：
Academic support Academy Achievement Address Appalachian Region Area Biological Models Caring Clinical Clinical Research Clinical Sciences Clinical Trials Clinical and Translational Science Awards Collaborations Communities Community Physician Contracts Data Environment Fostering Foundations Funding Goals Health Health system Healthcare Healthcare Systems Incentives Informatics Institutes Institutional Review Boards Interdisciplinary Study Knowledge Laboratories Leadership Learning Link Longevity Mentors Methods Mission Modeling Multicenter Trials NCI Scholars Program North Carolina Participant Population Positioning Attribute Process Program Development Reproducibility Research Research Infrastructure Research Personnel Research Support Research Training Resources Role Safety Scholarship Science Scientific Advances and Accomplishments Scientist Special Population Speed Structure System TNFSF15 gene Testing Textiles Training Training Programs Translational Research Translations Vision Workforce Development biomedical informatics catalyst data sharing design early-career faculty education research education resources empowered experience forest implementation science improved informatics infrastructure innovation member next generation nonhuman primate population health pre-clinical precision medicine programs skills success tool translational pipeline workforce needs

项目摘要

Contact PD/PI: MCCLAIN, DONALD A. Summary: Overall When the Wake Forest (WF) Clinical and Translational Science Institute (CTSI) joined the CTSA consortium in August 2015, our goal was to use our resources to catalyze WF’s transformation into an exemplary Learning Health System in which “science, informatics, incentives, and culture are aligned for continuous improvement and innovation, with best practices seamlessly embedded in the delivery process and new knowledge captured as an integral by-product of the delivery experience.” We seek to extend this framework by integrating traditional academic goals of T0 – T4 discovery, translation, and scholarship to form a new vision—the Academic Learning Health System (aLHS). In our initial 3 years of funding, we have progressed towards our goal, establishing an integrated research governance model, with the CTSI at its core, to realize efficiencies and address roadblocks that hamper translational progress. We established Translational Catalysts to link the academic and clinical enterprises and designed training programs to develop the skills our workforce needs to make the aLHS a reality. We developed foundational informatics infrastructures essential to learning and growing, engaged communities and stakeholders to integrate diverse perspectives into the fabric of our aLHS, and created a milieu for nurturing innovative translational methods. We became a valued member of the CTSA national network, actively collaborating with 20 CTSA hubs, and shared our world-class nonhuman primate models with the consortium. With these successes, we turn to the next 5 years with strong assets in leadership, structure, scholarship, and culture that uniquely position us to realize the aLHS ideal. We will fully integrate our new Translational Catalysts – biomedical informatics, implementation science, precision medicine, healthcare innovation, and clinical trials – and use them, along with incentives for academic engagement, to mobilize our growing clinical network. We will develop, implement, and broadly disseminate improved methods and processes that will increase the efficiency, safety, and reproducibility of preclinical and clinical science. We will partner with our community to integrate special populations, and support health research across the lifespan. We will train our workforce for new roles, especially in team environments, with new training programs (e.g., TL1 aLHS Scholars Program, the Learning TREE online educational platform for individualized learning, Research-in-Action) and broaden our highly successful KL2 training for early-career faculty. We will serve as a hub for biomedical informatics, accelerating progress by enhancing existing resources, promoting collaboration and data sharing, and building new capacity. We will remain committed to inclusiveness, mutual respect, and multiple perspectives to act as a catalyst for change and healthy equity. We will further extend the reach of the aLHS into the communities served by our expanding health system and will broaden our collaborations with other CTSA hubs to share best practices and export the aLHS model – all guided by our ultimate goal of improving the health of our region and nation. Page 243 Project Summary/Abstract Contact PD/PI: MCCLAIN, DONALD A. Narrative: Overall The Wake Forest Clinical and Translational Science Institute seeks to become the model of an integrated Academic Learning Health System in which we develop, implement, offer tailored training tools, and broadly disseminate improved methods and processes to increase the efficiency, safety, and reproducibility of preclinical and clinical science. We will build on our achievements to fully integrate our new Translational Catalysts – biomedical informatics, implementation science, precision medicine, healthcare innovation and clinical trials – and use them to develop and test initiatives, deploying research findings across our growing clinical network. We will remain committed to training the next generation of scientists and leaders and will partner with our community and CTSA hubs to integrate special populations and support research across the lifespan to extend the benefits of our progress to the widest possible audience. Page 244

联系人 PD/PI：MCCLAIN, DONALD A. 总结：总体当维克森林 (WF) 临床和转化科学研究所 (CTSI) 加入 CTSA 联盟时 2015 年 8 月，我们的目标是利用我们的资源促进 WF 转型为模范学习 “科学、信息学、激励措施和文化相结合以持续改进的卫生系统和创新，将最佳实践无缝嵌入交付过程并捕获新知识作为交付体验不可或缺的副产品。” T0-T4的学术目标发现、翻译和学术形成新的愿景——学术学习卫生系统 (aLHS) 在最初 3 年的资助中，我们已经朝着我们的目标取得了进展，建立了一个以 CTSI 为核心的综合研究治理模型，以提高效率并解决障碍我们建立了转化催化剂来连接学术和临床。企业并设计了培训计划来培养我们的员工实现 ALHS 所需的技能。我们开发了对于学习和发展、参与社区至关重要的基础信息学基础设施和利益相关者将不同的观点融入到我们的 aLHS 结构中，并创造了一个培养我们积极成为 CTSA 国家网络的重要成员。与 20 个 CTSA 中心合作，并与该联盟分享我们世界一流的非人类灵长类动物模型。凭借这些成功，我们在领导力、结构、学术和知识方面拥有强大的资产，展望未来 5 年。这种文化使我们能够实现 aLHS 理想，我们将充分整合我们的新转化催化剂。 – 生物医学信息学、实施科学、精准医学、医疗保健创新和临床试验 – 并利用它们以及学术参与的激励措施来动员我们不断增长的临床网络。开发、实施和广泛传播改进的方法和流程，以提高效率，我们将与我们的社区合作整合临床前和临床科学的安全性和可重复性。我们将培训我们的员工以适应新的角色，特别是在团队环境中，通过新的培训计划（例如 TL1 aLHS 学者计划、学习计划） TREE 在线教育平台，用于个性化学习、研究在行动）并拓宽我们的高度为早期职业教师提供成功的 KL2 培训我们将作为生物医学信息学中心，加速发展。通过增强现有资源、促进协作和数据共享以及建设新能力来取得进展。我们将继续致力于包容、相互尊重和多元视角，以促进我们将进一步将 aLHS 的覆盖范围扩展到我们所服务的社区。卫生系统，并将扩大我们与其他 CTSA 中心不断扩大的合作，以分享最佳实践和导出 aLHS 模型——一切都以我们改善地区和国家健康的最终目标为指导。第243页项目概要/摘要联系人 PD/PI：MCCLAIN, DONALD A. 叙述：总体维克森林临床与转化科学研究所力求成为综合性研究机构的典范学术学习健康系统，我们在其中开发、实施、提供定制的培训工具，并广泛传播改进的方法和流程，以提高临床前的效率、安全性和可重复性我们将在我们的成就的基础上充分整合我们的新转化催化剂—— 生物医学信息学、科学实施、精准医疗、医疗保健创新和临床试验 – 并使用它们来开发和测试计划，在我们不断发展的临床网络中部署研究成果。我们将继续致力于培训下一代科学家和领导者，并将与我们的合作伙伴社区和 CTSA 中心整合特殊人群并支持整个生命周期的研究，以延长生命周期我们的进步让尽可能多的受众受益。第244页