Structural biology collaborations

结构生物学合作

• 批准号: 10926485
• 负责人: Susan Lea
• 金额: $ 56.54万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10926485
• 关键词: Biological Process; Cellular Membrane; Collaborations; Complex; Cryoelectron Microscopy; Genetic Transcription; Membrane; Molecular; Molecular Conformation; Nucleic Acid Folding; Proteins; RNA; RNA Folding; Signal Transduction; Structure; T-Cell Development; Technology; Translations; structural biology

We are using the expertise and the state of the art cryoEM technology in the Center of Structural Biology to assist our intramural collaborators on a number of projects. Specific projects include: 1) trying better to understand how the complexes formed under the cellular membrane drive T-cell development; 2) how protein-RNA complexes regulate translation and transcription and 3) how folded RNAs regulate activity by shifting conformational space. We anticipate additional projects over the coming year.

我们在结构生物学的中心使用了技术冷冻技术的专业知识和状态，以协助我们的壁内合作者进行许多项目。特定项目包括：1）更好地了解细胞膜驱动T细胞开发下的复合物如何； 2）蛋白-RNA复合物如何调节翻译和转录以及3）折叠RNA如何通过转移构象空间调节活性。我们预计来年有其他项目。