Eukaryotic Protein Maturation and Transport

真核蛋白质的成熟和运输

• 批准号: 10702850
• 负责人: Susan Lea
• 金额: $ 62.57万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10702850
• 关键词: Anti-Bacterial Agents; Binding; Carrier Proteins; Cells; Disease; Ensure; Goals; Health; Human; Huntington Disease; Infection; Malignant Neoplasms; Membrane Proteins; Pharmaceutical Preparations; Proteins; Publishing; Signal Transduction; Structure; Therapeutic Agents; Work; anti-cancer; improved; novel; protein folding; small molecule; structural biology

Control of entry of molecules to the cell is fundamental to cellular health as is ensuring that proteins are correctly folded and incorporated in the right cellular compartment. We are using structural biology to dissect the membrane proteins that achieve these goals. This year we have published structures that now form the start point for larger studies of drug-bound forms that will enable redesign of therapies for both cancer and novel anti-bacterial agents. Additionally, we have extended our work to delineate the structural basis for the association with disease of expansions of the HTT protein in Huntington's Disease.

控制分子到细胞的进入是细胞健康的基础，可以确保蛋白质正确折叠并掺入右细胞室中。我们正在使用结构生物学来剖析实现这些目标的膜蛋白。今年，我们发布了现在的结构，这些结构现在构成了对药物结合形式进行更大研究的起点，这些研究将能够重新设计癌症和新型抗细菌剂的疗法。此外，我们扩大了工作，以描述与亨廷顿氏病中HTT蛋白扩张疾病相关的结构性基础。