Clinical Support Services for the NIAMS Intramural Research Program

NIAMS 校内研究项目的临床支持服务

• 批准号: 10926673
• 负责人: Robert Colbert
• 金额: $ 1162.2万
• 依托单位: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10926673
• 关键词: Adult-Onset Still' s Disease; Agonist; Ambulatory Care Facilities; Ankylosing spondylitis; Appointments and Schedules; Autoimmune Diseases; Blood Vessels; Clinical; Clinical Protocols; Clinical Research; Consult; Contracts; Databases; Dermatologic; Dermatology; Dermatomyositis; Disease; Double-Blind Method; Evaluation; Fellowship; Frequencies; Functional disorder; Genetic; Genetic Determinism; Genomics; Glucocorticoids; Hospitalists; IgG1; Inflammatory; Infrastructure; Inpatients; Institutional Review Boards; Intramural Research Program; Investigation; Juvenile Dermatomyositis; Longitudinal Studies; Lupus; Medical; Medicare; Melorheostosis; Monoclonal Antibodies; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Natural History; Neighborhood Health Center; Nurse Practitioners; Nursing Research; Orthopedic Procedures; Orthopedics; Outcome; Outpatients; PPAR gamma; Pathogenesis; Patient Admission; Patient Care; Patients; Phase; Physician Assistants; Physicians; Polymyositis; Preparation; Prevention; Prospective Studies; Protocols documentation; Randomized; Research; Research Activity; Research Infrastructure; Research Personnel; Research Support; Rheumatism; Rheumatoid Arthritis; Rheumatology; Role; Safety; Services; Severities; Specialist; Spinal Fusion; Spondylarthritis; Syndrome; Systemic Lupus Erythematosus; TNF gene; Training Programs; Translational Research; Travel; Treatment Protocols; United States National Institutes of Health; Vasculitis; Washington; autoinflammatory; beneficiary; clinical center; coronavirus disease; cost; immunoregulation; minority communities; omalizumab; open label; operation; placebo controlled study; programs; standard care; systemic autoimmune disease; systemic juvenile idiopathic arthritis

This project has provided research infrastructure support for FY23 for the clinical protocols listed below. These protocols serve a variety of research needs for investigators in the NIAMS. 03-AR-0173: Studies of the Natural History, Pathogenesis and Outcome in Autoimmune and Inflammatory Diseases Including Juvenile Dermatomyositis 11-AR-0223: Studies on the Natural History and Pathogenesis of Spondyloarthritis 12-AR-8001: Compassionate Use Treatment Protocol 14V-MC-JAGA Treatment of Autoinflammatory Syndromes Expected to Benefit from JAK 1/2 Inhibition 18-AR-0081: Investigation of the Natural History, Genetics and Pathophysiology of Systemic Juvenile Idiopathic Arthritis and Adult-onset Still's Disease and Related Inflammatory Conditions 91-AR-0196: Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related Diseases 01-AR-0227: Natural History of Rheumatic Disease in Minority Communities 14-AR-0200: Studies of the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis 15-AR-0165: Study of the Natural History, Pathogenesis and Outcome of Melorheostosis-a Rare Osteosclerotic Disease 03-AR-0131: Genetic Determinants of Ankylosing Spondylitis Severity - Longitudinal Study 04-AR-0205: Progression of Spinal Fusion in Ankylosing Spondylitis 15-AR-0060: The Role of PPAR-gamma Agonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE) 94-AR-0066: Studies of the Pathogenesis and Natural History of Systemic Lupus Erythematosus (SLE) 13-AR-0056: Stopping Anti-TNF Agents in Rheumatoid Arthritis (STARA) Trial 15-AR-N010: Frequency and Complications of Major Orthopedic Procedures in Medicare Beneficiaries 96-AR-0102: Standard Care Dermatology; Evaluation and treatment of subjects with dermatologic diseases 000207: SAD-COVID: The natural history of coronavirus disease (COVID-19) in systemic autoimmune diseases; an observational prospective study 20-AR-0032: Glucocorticoid Genomics in SLE; Genomic effects of glucocorticoids in patients with systemic lupus erythematosus 13-AR-0005: STOP LUPUS: A phase 1b, randomized, double-blind, placebo controlled study with an open label extension to evaluate the safety and tolerability of Omalizumab, a humanized IgG1 monoclonal antibody in patients with lupus (STOP LUPUS)

该项目为FY23提供了下面列出的临床方案的研究基础设施支持。这些方案为NIAMS的研究人员提供了各种研究需求。 03-AR-0173：自身免疫性和炎症性疾病的自然病史，发病机理和结局的研究 11-AR-0223：关于脊椎关节炎的自然病史和发病机理的研究 8001年12月12日：富有同情心的治疗方案14V-MC-JAGA治疗自身炎症综合征的治疗方法预计将受益于JAK 1/2抑制 20081年18月18日：全身少年特发性关节炎和成人疾病的自然史，遗传学和病理生理学的研究 91-AR-0196：关于多肌炎，皮肤炎和相关疾病的自然病史和发病机理的研究 01-AR-0227：少数民族疾病的自然历史 14-AR-0200：对特发性全身血管炎的自然病史，发病机理和结果的研究 15-AR-0165：对情绪低落的自然病史，发病机理和结局的研究 03-AR-0131：强直性脊柱炎严重程度的遗传决定因素 - 纵向研究 04-AR-0205：强直性脊柱炎的脊柱融合进展 15-ar-0060：PPAR-GAMMA激动剂在SLE（PPAR-SLE）中的免疫调节和血管预防中的作用 94-ar-0066：全身性红斑狼疮的发病机理和自然历史研究（SLE） 13-ar-0056：在类风湿关节炎（Stara）试验中停止抗TNF药物 15-AR-N010：Medicare受益人主要骨科手术的频率和并发症 96-AR-0102：标准护理皮肤病学；评估和治疗皮肤病学疾病的受试者 000207：悲伤：全身自身免疫性疾病中冠状病毒病的自然史（Covid-19）；观察性的前瞻性研究 20032年20月20日：SLE中的糖皮质激素基因组学；糖皮质激素对全身性红斑狼疮患者的基因组作用 13-ar-0005：停止狼疮：1B期，随机，双盲，安慰剂对照研究，带有开放式标签扩展，以评估狼疮患者中人源化的IgG1 IgG1单克隆抗体的安全性和耐受性（停止卢普斯（Stop Lupus））

项目成果

Syndesmophyte growth in ankylosing spondylitis.

• DOI: 10.1097/bor.0000000000000179
• 发表时间: 2015-07
• 期刊: Current opinion in rheumatology
• 影响因子: 5.1
• 作者: Tan S;Wang R;Ward MM
• 通讯作者: Ward MM

Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease.

• DOI: 10.1056/nejmoa2026834
• 发表时间: 2020-12-31
• 期刊: The New England journal of medicine
• 作者: Beck DB;Ferrada MA;Sikora KA;Ombrello AK;Collins JC;Pei W;Balanda N;Ross DL;Ospina Cardona D;Wu Z;Patel B;Manthiram K;Groarke EM;Gutierrez-Rodrigues F;Hoffmann P;Rosenzweig S;Nakabo S;Dillon LW;Hourigan CS;Tsai WL;Gupta S;Carmona-Rivera C;Asmar AJ;Xu L;Oda H;Goodspeed W;Barron KS;Nehrebecky M;Jones A;Laird RS;Deuitch N;Rowczenio D;Rominger E;Wells KV;Lee CR;Wang W;Trick M;Mullikin J;Wigerblad G;Brooks S;Dell'Orso S;Deng Z;Chae JJ;Dulau-Florea A;Malicdan MCV;Novacic D;Colbert RA;Kaplan MJ;Gadina M;Savic S;Lachmann HJ;Abu-Asab M;Solomon BD;Retterer K;Gahl WA;Burgess SM;Aksentijevich I;Young NS;Calvo KR;Werner A;Kastner DL;Grayson PC
• 通讯作者: Grayson PC

Pathogenesis and Management of Sarcopenia.

• DOI: 10.1016/j.cger.2016.08.002
• 发表时间: 2017-02
• 期刊: Clinics in geriatric medicine
• 影响因子: 3.3
• 作者: Dhillon RJ;Hasni S
• 通讯作者: Hasni S

VEXAS Syndrome: A Case Series From a Single-Center Cohort of Italian Patients With Vasculitis.

VEXAS 综合征：意大利血管炎单中心队列的病例系列。

• DOI: 10.1002/art.41992
• 发表时间: 2022-04
• 期刊: Arthritis & rheumatology (Hoboken, N.J.)
• 作者: Muratore F;Marvisi C;Castrignanò P;Nicoli D;Farnetti E;Bonanno O;Longo R;Zaldini P;Galli E;Balanda N;Beck DB;Grayson PC;Pipitone N;Boiardi L;Salvarani C
• 通讯作者: Salvarani C

Time perspective and exercise, obesity, and smoking: moderation of associations by age.

时间观念与锻炼、肥胖和吸烟：年龄相关性的调节。

• DOI: 10.4278/ajhp.130122-quan-39
• 发表时间: 2014-09
• 期刊: American journal of health promotion : AJHP
• 作者: Guthrie LC;Butler SC;Lessl K;Ochi O;Ward MM
• 通讯作者: Ward MM